Details for: AHCYL2

Gene ID: 23382

Symbol: AHCYL2

Ensembl ID: ENSG00000158467

Description: adenosylhomocysteinase like 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.22
    Marker Score: 3,469
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.12
    Marker Score: 73,069
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.42
    Marker Score: 115,505
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.41
    Marker Score: 2,242
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.3
    Marker Score: 1,737
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.17
    Marker Score: 67,639
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.15
    Marker Score: 13,180
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.52
    Marker Score: 1,942
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.52
    Marker Score: 736
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.35
    Marker Score: 799
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.23
    Marker Score: 2,531
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.23
    Marker Score: 935
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.22
    Marker Score: 11,950
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.18
    Marker Score: 6,220
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.14
    Marker Score: 78,917
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.1
    Marker Score: 41,846
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.06
    Marker Score: 8,545
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.03
    Marker Score: 32,614
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.01
    Marker Score: 5,031
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.95
    Marker Score: 20,120
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.93
    Marker Score: 18,137
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.92
    Marker Score: 947
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7,797
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 116,621
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.85
    Marker Score: 1,107
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.85
    Marker Score: 70,219
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.81
    Marker Score: 17,213
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15,386
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.79
    Marker Score: 3,004
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.78
    Marker Score: 13,645
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.76
    Marker Score: 1,941
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.74
    Marker Score: 5,850
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.74
    Marker Score: 1,504
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.73
    Marker Score: 6,152
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.73
    Marker Score: 4,140
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.7
    Marker Score: 464
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.69
    Marker Score: 3,875
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.68
    Marker Score: 483
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.64
    Marker Score: 8,609
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.63
    Marker Score: 12,262
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.61
    Marker Score: 3,525
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.6
    Marker Score: 7,422
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.59
    Marker Score: 2,133
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.58
    Marker Score: 1,368
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.58
    Marker Score: 3,041
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.57
    Marker Score: 2,423
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.56
    Marker Score: 6,033
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.52
    Marker Score: 480
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.51
    Marker Score: 1,739
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.48
    Marker Score: 860
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.48
    Marker Score: 4,646
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.48
    Marker Score: 1,026
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 21,931
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,824
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.44
    Marker Score: 840
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.42
    Marker Score: 9,231
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.42
    Marker Score: 1,256
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.4
    Marker Score: 726
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4
    Marker Score: 537
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.37
    Marker Score: 1,034
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.37
    Marker Score: 1,478
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.37
    Marker Score: 768
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.33
    Marker Score: 5,536
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.32
    Marker Score: 419
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.32
    Marker Score: 767
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.29
    Marker Score: 3,048
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2,596
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.24
    Marker Score: 27,796
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.24
    Marker Score: 1,551
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.23
    Marker Score: 1,731
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.22
    Marker Score: 1,505
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.19
    Marker Score: 572
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.18
    Marker Score: 3,850
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.17
    Marker Score: 378
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.17
    Marker Score: 655
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,335
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.16
    Marker Score: 422
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.16
    Marker Score: 1,106
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.16
    Marker Score: 1,154
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.15
    Marker Score: 1,393
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.14
    Marker Score: 290
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.14
    Marker Score: 1,610
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.12
    Marker Score: 1,949
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.11
    Marker Score: 368
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.1
    Marker Score: 545
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.09
    Marker Score: 1,268
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.07
    Marker Score: 1,715
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.06
    Marker Score: 5,569
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.06
    Marker Score: 390
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.04
    Marker Score: 685
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.04
    Marker Score: 1,256
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.03
    Marker Score: 1,082
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.02
    Marker Score: 445
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.01
    Marker Score: 1,077
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1
    Marker Score: 6,451
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,975
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1
    Marker Score: 1,446
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 306

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AHCYL2 is a gene that shares structural and functional similarities with SAHH, suggesting a conserved evolutionary origin. The gene is highly expressed in various cell types, including syncytiotrophoblast cells, cortical cells of the adrenal gland, Purkinje cells, and mature astrocytes. These cells are involved in different physiological processes, such as fetal development, stress response, and neurotransmission, underscoring the potential importance of AHCYL2 in these contexts. Notably, AHCYL2 is also expressed in cells involved in the transport of small molecules, including inorganic cations, amino acids, and oligopeptides, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions:** AHCYL2 is involved in the regulation of the one-carbon metabolic pathway, which is essential for the synthesis of nucleotides, amino acids, and other biomolecules. This pathway is crucial for various cellular processes, including DNA synthesis, cell growth, and differentiation. AHCYL2 also plays a role in the transport of small molecules across cellular membranes, including inorganic cations, amino acids, and oligopeptides. This function is mediated through its involvement in the S-adenosylmethionine (SAM) cycle, which is a key regulatory pathway in one-carbon metabolism. The S-adenosylmethionine cycle is a critical metabolic pathway that involves the conversion of homocysteine to methionine, with AHCYL2 as a key player. This cycle is essential for the synthesis of SAM, which is a crucial cofactor for various enzymes involved in one-carbon metabolism. AHCYL2's involvement in this cycle suggests that it plays a regulatory role in the synthesis of SAM, which in turn affects various cellular processes. **Clinical Significance:** AHCYL2's involvement in one-carbon metabolism and small molecule transport has significant implications for human health. Dysregulation of the one-carbon metabolic pathway has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular disease. AHCYL2's role in maintaining cellular homeostasis also suggests that dysregulation of this gene may contribute to various diseases, including those involving cellular stress and damage. Furthermore, AHCYL2's expression in cells involved in fetal development and stress response suggests that its dysregulation may contribute to developmental disorders and stress-related diseases. The identification of AHCYL2 as a potential therapeutic target for these diseases highlights the need for further research into its functions and mechanisms of action. In conclusion, AHCYL2 is a gene that plays a critical role in the regulation of one-carbon metabolism and small molecule transport. Its involvement in these processes has significant implications for human health, and its dysregulation may contribute to various diseases. Further research into the functions and mechanisms of action of AHCYL2 is necessary to fully appreciate its significance and potential therapeutic applications.

Genular Protein ID: 622222156

Symbol: SAHH3_HUMAN

Name: Adenosylhomocysteinase 3

UniProtKB Accession Codes:

Q96HN2 B4DIZ5 D9N155 O94917

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19220705

Title: An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.

PubMed ID: 19220705

DOI: 10.1111/j.1471-4159.2009.05979.x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31799605

Title: The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.

PubMed ID: 31799605

DOI: 10.1093/nar/gkz1147

Sequence Information:

  • Length: 611
  • Mass: 66721
  • Checksum: A76B1275FC0D891D
  • Sequence:
    • MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP 
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK 
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS 
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA 
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE 
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN 
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV 
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH 
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA 
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK 
NGPFKPNYYR Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.