Associated with
Other Information
Genular Protein ID: 2721288132
Symbol: NICA_HUMAN
Name: Nicastrin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10993067
Title: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
PubMed ID: 10993067
DOI: 10.1038/35024009
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 11396676
Title: Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines.
PubMed ID: 11396676
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 12740439
Title: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
PubMed ID: 12740439
PubMed ID: 12679784
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 25043039
Title: Three-dimensional structure of human gamma-secretase.
PubMed ID: 25043039
DOI: 10.1038/nature13567
PubMed ID: 26623517
Title: Sampling the conformational space of the catalytic subunit of human gamma-secretase.
PubMed ID: 26623517
DOI: 10.7554/elife.11182
PubMed ID: 26280335
PubMed ID: 25918421
Title: Structural basis of human gamma-secretase assembly.
PubMed ID: 25918421
PubMed ID: 26776682
Title: Structure of the transmembrane domain of human nicastrin-a component of gamma-secretase.
PubMed ID: 26776682
DOI: 10.1038/srep19522
PubMed ID: 30598546
Title: Structural basis of Notch recognition by human gamma-secretase.
PubMed ID: 30598546
PubMed ID: 30630874
Title: Recognition of the amyloid precursor protein by human gamma-secretase.
PubMed ID: 30630874
PubMed ID: 20929727
Title: Gamma-secretase gene mutations in familial acne inversa.
PubMed ID: 20929727
PubMed ID: 21430701
Title: Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa).
PubMed ID: 21430701
DOI: 10.1038/jid.2011.62
PubMed ID: 21495993
Title: Two novel mutations of the nicastrin gene in Chinese patients with acne inversa.
PubMed ID: 21495993
Sequence Information:
- Length: 709
- Mass: 78411
- Checksum: C8C0EAEAD89E976A
- Sequence:
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQCYQDHN LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF SINPEIVCDP LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENVD SFVELGQVAL RTSLELWMHT DPVSQKNESV RNQVEDLLAT LEKSGAGVPA VILRRPNQSQ PLPPSSLQRF LRARNISGVV LADHSGAFHN KYYQSIYDTA ENINVSYPEW LSPEEDLNFV TDTAKALADV ATVLGRALYE LAGGTNFSDT VQADPQTVTR LLYGFLIKAN NSWFQSILRQ DLRSYLGDGP LQHYIAVSSP TNTTYVVQYA LANLTGTVVN LTREQCQDPS KVPSENKDLY EYSWVQGPLH SNETDRLPRC VRSTARLARA LSPAFELSQW SSTEYSTWTE SRWKDIRARI FLIASKELEL ITLTVGFGIL IFSLIVTYCI NAKADVLFIA PREPGAVSY
Genular Protein ID: 935578728
Symbol: A0A8V8TPR8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 571
- Mass: 63311
- Checksum: F9333A09FD4E49FF
- Sequence:
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQETFDYI GSSRMVYDME KGKFPVQLEN VDSFVELGQV ALRTSLELWM HTDPVSQKNE SVRNQVEDLL ATLEKSGAGV PAVILRRPNQ SQPLPPSSLQ RFLRARNISG VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL ELITLTVGFG ILIFSLIVTY CINAKADVLF IAPREPGAVS Y
Genular Protein ID: 3843880661
Symbol: A0A8V8TPQ8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 395
- Mass: 43366
- Checksum: 4C54526DC03BC51C
- Sequence:
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQCYQDHN LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF SINPEIVCDP LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENVD SFVELGQVAL RTSLELWMHT DPVSQKNESV RNQGL
Genular Protein ID: 2714249400
Symbol: B4DR82_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 571
- Mass: 63248
- Checksum: F32313E940E6CF53
- Sequence:
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQETFDYI GSSRMVYDME KGKFPVQLEN VDSFVELGQV ALRTSLELLM HTDPVSQKNE SVRNQVEDLL ATLEKSGAGV PAVILRRPNQ SQPLPPSSLQ RFLRARNISG VVLADHPGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL ELITLTVGFG ILIFSLIVTY CINAKADVLF IAPREPGAVS Y
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.