Details for: SIK3

Gene ID: 23387

Symbol: SIK3

Ensembl ID: ENSG00000160584

Description: SIK family kinase 3

Associated with

Other Information

Genular Protein ID: 1688867715

Symbol: SIK3_HUMAN

Name: Salt-inducible kinase 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15334068

Title: Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.

PubMed ID: 15334068

DOI: 10.1038/sj.onc.1207921

PubMed ID: 16306228

Title: 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

PubMed ID: 16306228

DOI: 10.1242/jcs.02670

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29211348

Title: 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).

PubMed ID: 29211348

DOI: 10.1111/febs.14351

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30232230

Title: The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

PubMed ID: 30232230

DOI: 10.1126/scitranslmed.aat9356

Sequence Information:

  • Length: 1321
  • Mass: 144851
  • Checksum: 84FA57F6BB5505DA
  • Sequence:
  • MAAAAASGAG GAAGAGTGGA GPAGRLLPPP APGSPAAPAA VSPAAGQPRP PAPASRGPMP 
    ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKT QLDEENLKKI FREVQIMKML 
    CHPHIIRLYQ VMETERMIYL VTEYASGGEI FDHLVAHGRM AEKEARRKFK QIVTAVYFCH 
    CRNIVHRDLK AENLLLDANL NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD 
    GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL 
    DPNKRLSMEQ ICKHKWMKLG DADPNFDRLI AECQQLKEER QVDPLNEDVL LAMEDMGLDK 
    EQTLQSLRSD AYDHYSAIYS LLCDRHKRHK TLRLGALPSM PRALAFQAPV NIQAEQAGTA 
    MNISVPQVQL INPENQIVEP DGTLNLDSDE GEEPSPEALV RYLSMRRHTV GVADPRTEVM 
    EDLQKLLPGF PGVNPQAPFL QVAPNVNFMH NLLPMQNLQP TGQLEYKEQS LLQPPTLQLL 
    NGMGPLGRRA SDGGANIQLH AQQLLKRPRG PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA 
    VQSSTYKDSN TLHLPTERFS PVRRFSDGAA SIQAFKAHLE KMGNNSSIKQ LQQECEQLQK 
    MYGGQIDERT LEKTQQQHML YQQEQHHQIL QQQIQDSICP PQPSPPLQAA CENQPALLTH 
    QLQRLRIQPS SPPPNHPNNH LFRQPSNSPP PMSSAMIQPH GAASSSQFQG LPSRSAIFQQ 
    QPENCSSPPN VALTCLGMQQ PAQSQQVTIQ VQEPVDMLSN MPGTAAGSSG RGISISPSAG 
    QMQMQHRTNL MATLSYGHRP LSKQLSADSA EAHSLNVNRF SPANYDQAHL HPHLFSDQSR 
    GSPSSYSPST GVGFSPTQAL KVPPLDQFPT FPPSAHQQPP HYTTSALQQA LLSPTPPDYT 
    RHQQVPHILQ GLLSPRHSLT GHSDIRLPPT EFAQLIKRQQ QQRQQQQQQQ QQQEYQELFR 
    HMNQGDAGSL APSLGGQSMT ERQALSYQNA DSYHHHTSPQ HLLQIRAQEC VSQASSPTPP 
    HGYAHQPALM HSESMEEDCS CEGAKDGFQD SKSSSTLTKG CHDSPLLLST GGPGDPESLL 
    GTVSHAQELG IHPYGHQPTA AFSKNKVPSR EPVIGNCMDR SSPGQAVELP DHNGLGYPAR 
    PSVHEHHRPR ALQRHHTIQN SDDAYVQLDN LPGMSLVAGK ALSSARMSDA VLSQSSLMGS 
    QQFQDGENEE CGASLGGHEH PDLSDGSQHL NSSCYPSTCI TDILLSYKHP EVSFSMEQAG 
    V

Genular Protein ID: 2094701757

Symbol: A1A5A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1102
  • Mass: 121747
  • Checksum: 9761B08C90131E4A
  • Sequence:
  • MAEKEARRKF KQIVTAVYFC HCRNIVHRDL KAENLLLDAN LNIKIADFGF SNLFTPGQLL 
    KTWCGSPPYA APELFEGKEY DGPKVDIWSL GVVLYVLVCG ALPFDGSTLQ NLRARVLSGK 
    FRIPFFMSTE CEHLIRHMLV LDPNKRLSME QICKHKWMKL GDADPNFDRL IAECQQLKEE 
    RQVDPLNEDV LLAMEDMGLD KEQTLQSLRS DAYDHYSAIY SLLCDRHKRH KTLRLGALPS 
    MPRALAFQAP VNIQAEQAGT AMNISVPQVQ LINPENQIVE PDGTLNLDSD EGEEPSPEAL 
    VRYLSMRRHT VGVADPRTEV MEDLQKLLPG FPGVNPQAPF LQVAPNVNFM HNLLPMQNLQ 
    PTGQLEYKEQ SLLQPPTLQL LNGMGPLGRR ASDGGANIQL HAQQLLKRPR GPSPLVTMTP 
    AVPAVTPVDE ESSDGEPDQE AVQSSTYKDS NTLHLPTERF SPVRRFSDGA ASIQAFKAHL 
    EKMGNNSSIK QLQQECEQLQ KMYGGQIDER TLEKTQQQHM LYQQEQHHQI LQQQIQDSIC 
    PPQPSPPLQA ACENQPALLT HQLQRLRIQP SSPPPNHPNN HLFRQPSNSP PPMSSAMIQP 
    HGAASSSQFQ GLPSRSAIFQ QQPENCSSPP NVALTCLGMQ QPAQSQQVTI QVQEPVDMLS 
    NMPGTAAGSS GRGISISPSA GQMQMQHRTN LMATLSYGHR PLSKQLSADS AEAHSAHQQP 
    PHYTTSALQQ ALLSPTPPDY TRHQQVPHIL QGLLSPRHSL TGHSDIRLPP TEFAQLIKRQ 
    QQQRQQQQQQ QQQQEYQELF RHMNQGDAGS LAPSLGGQSM TERQALSYQN ADSYHHHTSP 
    QHLLQIRAQE CVSQASSPTP PHGYAHQPAL MHSESMEEDC SCEGAKDGFQ DSKSSSTLTK 
    GCHDSPLLLS TGGPGDPESL LGTVSHAQEL GIHPYGHQPT AAFSKNKVPS REPVIGNCMD 
    RSSPGQAVEL PDHNGLGYPA RPSVHEHHRP RALQRHHTIQ NSDDAYVQLD NLPGMSLVAG 
    KALSSARMSD AVLSQSSLMG SQQFQDGENE ECGASLGGHE HPDLSDGSQH LNSSCYPSTC 
    ITDILLSYKH PEVSFSMEQA GV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.