Details for: ZDHHC17

Gene ID: 23390

Symbol: ZDHHC17

Ensembl ID: ENSG00000186908

Description: zinc finger DHHC-type palmitoyltransferase 17

Associated with

Other Information

Genular Protein ID: 2667601051

Symbol: ZDH17_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12393793

Title: HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

PubMed ID: 12393793

DOI: 10.1093/hmg/11.23.2815

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9700202

Title: Huntingtin interacts with a family of WW domain proteins.

PubMed ID: 9700202

DOI: 10.1093/hmg/7.9.1463

PubMed ID: 15603740

Title: Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.

PubMed ID: 15603740

DOI: 10.1016/j.neuron.2004.11.027

PubMed ID: 15489887

Title: Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase.

PubMed ID: 15489887

DOI: 10.1038/sj.onc.1208171

PubMed ID: 18032660

Title: Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.

PubMed ID: 18032660

DOI: 10.1523/jneurosci.2464-07.2007

PubMed ID: 18794299

Title: Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport.

PubMed ID: 18794299

DOI: 10.1074/jbc.m801469200

PubMed ID: 19139280

Title: ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.

PubMed ID: 19139280

DOI: 10.1128/mcb.00754-08

PubMed ID: 22496366

Title: Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.

PubMed ID: 22496366

DOI: 10.1074/jbc.m111.332981

PubMed ID: 29475958

Title: Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.

PubMed ID: 29475958

DOI: 10.1074/jbc.w118.002209

PubMed ID: 25547411

Title: Identifying tandem Ankyrin repeats in protein structures.

PubMed ID: 25547411

DOI: 10.1186/s12859-014-0440-9

PubMed ID: 24705354

Title: The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

PubMed ID: 24705354

DOI: 10.1093/hmg/ddu137

PubMed ID: 26198635

Title: Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases.

PubMed ID: 26198635

DOI: 10.1074/jbc.m115.657668

PubMed ID: 27911442

Title: Palmitoylation of caspase-6 by HIP14 regulates its activation.

PubMed ID: 27911442

DOI: 10.1038/cdd.2016.139

PubMed ID: 28882895

Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.

PubMed ID: 28882895

DOI: 10.1074/jbc.m117.799650

PubMed ID: 19434754

Title: The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding.

PubMed ID: 19434754

DOI: 10.1002/prot.22452

PubMed ID: 28757145

Title: Structural basis for substrate recognition by the ankyrin repeat domain of human DHHC17 palmitoyltransferase.

PubMed ID: 28757145

DOI: 10.1016/j.str.2017.06.018

Sequence Information:

  • Length: 632
  • Mass: 72640
  • Checksum: 3FD5FD592F2C617F
  • Sequence:
  • MQREEGFNTK MADGPDEYDT EAGCVPLLHP EEIKPQSHYN HGYGEPLGRK THIDDYSTWD 
    IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN NRIDLVKYYI SKGAIVDQLG 
    GDLNSTPLHW ATRQGHLSMV VQLMKYGADP SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG 
    QDVDMMDQNG MTPLMWAAYR THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV 
    ISLLLEAGAN VDAQNIKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE 
    FRQKVMLGTP FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF DHSMHSALPL 
    GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY NFGKSWKSDP GIIKATEEQK 
    KKTIVELAET GSLDLSIFCS TCLIRKPVRS KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR 
    YFMGYLFFLL FMICWMIYGC ISYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF 
    HFMWVAVLLM CQMYQISCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF 
    RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.