Details for: ECPAS

Gene ID: 23392

Symbol: ECPAS

Ensembl ID: ENSG00000136813

Description: Ecm29 proteasome adaptor and scaffold

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.27
    Marker Score: 70,161
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.54
    Marker Score: 1,721
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.24
    Marker Score: 8,116
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.28
    Marker Score: 5,002
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.21
    Marker Score: 2,441
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.18
    Marker Score: 3,658
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.09
    Marker Score: 612
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.05
    Marker Score: 2,357
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.04
    Marker Score: 40,599
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.03
    Marker Score: 43,276
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.98
    Marker Score: 73,012
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.96
    Marker Score: 29,239
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.94
    Marker Score: 73,700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.94
    Marker Score: 18,226
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.91
    Marker Score: 7,377
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.91
    Marker Score: 4,568
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.9
    Marker Score: 7,869
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.89
    Marker Score: 6,729
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.89
    Marker Score: 14,501
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.89
    Marker Score: 42,218
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 115,975
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.89
    Marker Score: 993
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.88
    Marker Score: 928
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.87
    Marker Score: 783
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.83
    Marker Score: 1,621
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.82
    Marker Score: 17,267
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.81
    Marker Score: 1,083
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18,702
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.78
    Marker Score: 2,013
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,249
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.77
    Marker Score: 7,392
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.74
    Marker Score: 3,357
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.74
    Marker Score: 1,020
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.72
    Marker Score: 1,130
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.7
    Marker Score: 1,181
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.7
    Marker Score: 944
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.69
    Marker Score: 984
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.64
    Marker Score: 598
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.63
    Marker Score: 7,556
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.59
    Marker Score: 1,985
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.57
    Marker Score: 408
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.57
    Marker Score: 1,439
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.56
    Marker Score: 4,440
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,398
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.55
    Marker Score: 868
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.54
    Marker Score: 1,186
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.52
    Marker Score: 6,175
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.45
    Marker Score: 1,553
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.45
    Marker Score: 397
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.44
    Marker Score: 963
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.44
    Marker Score: 1,737
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.39
    Marker Score: 1,864
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.35
    Marker Score: 498
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.34
    Marker Score: 1,674
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.33
    Marker Score: 1,265
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.31
    Marker Score: 333
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.29
    Marker Score: 372
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.26
    Marker Score: 399
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.24
    Marker Score: 391
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.22
    Marker Score: 2,773
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.2
    Marker Score: 1,295
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2
    Marker Score: 40,669
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.17
    Marker Score: 470
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.16
    Marker Score: 394
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.14
    Marker Score: 429
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.12
    Marker Score: 356
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17,556
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.12
    Marker Score: 1,648
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.12
    Marker Score: 405
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.11
    Marker Score: 1,172
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.08
    Marker Score: 631
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.08
    Marker Score: 1,548
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.07
    Marker Score: 712
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.06
    Marker Score: 575
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.06
    Marker Score: 4,392
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.06
    Marker Score: 1,496
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.06
    Marker Score: 1,097
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.05
    Marker Score: 277
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.05
    Marker Score: 2,220
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.05
    Marker Score: 522
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1,128
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.04
    Marker Score: 330
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2,428
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1,283
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 692
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,664
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,891
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.99
    Marker Score: 649
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,387
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.98
    Marker Score: 8,592
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.97
    Marker Score: 453
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.96
    Marker Score: 222
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.95
    Marker Score: 960
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.94
    Marker Score: 1,167
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.94
    Marker Score: 3,333
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.94
    Marker Score: 270
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.92
    Marker Score: 824
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ECPAS is a protein that functions as a proteasome adaptor and scaffold, facilitating the assembly of proteasomes, which are essential for protein degradation. The ECM29 protein, encoded by ECPAS, interacts with various proteins and components of the proteasome complex, regulating its activity and stability. Additionally, ECPAS is involved in the regulation of endocytic and exocytic pathways, including the Copii-coated endosome-to-Golgi transport vesicle pathway and the ER-Golgi intermediate compartment. This suggests that ECPAS plays a critical role in maintaining cellular homeostasis and regulating protein trafficking. **Pathways and Functions:** ECPAS is involved in several key cellular pathways, including: 1. **Proteasome Assembly and Regulation**: ECPAS facilitates the assembly of proteasomes, which are responsible for protein degradation. The ECM29 protein interacts with various components of the proteasome complex, regulating its activity and stability. 2. **Endocytic and Exocytic Pathways**: ECPAS is involved in the regulation of endocytic and exocytic pathways, including the Copii-coated endosome-to-Golgi transport vesicle pathway and the ER-Golgi intermediate compartment. This suggests that ECPAS plays a critical role in maintaining cellular homeostasis and regulating protein trafficking. 3. **Cellular Homeostasis**: ECPAS is involved in maintaining cellular homeostasis by regulating protein degradation and protein trafficking. Dysregulation of ECPAS has been implicated in various diseases, including cancer and neurodegenerative disorders. **Clinical Significance:** ECPAS has significant clinical relevance, particularly in the context of diseases associated with proteasome dysfunction. Dysregulation of ECPAS has been implicated in various conditions, including: 1. **Cancer**: ECPAS dysfunction has been linked to cancer development and progression, highlighting the importance of ECPAS in maintaining cellular homeostasis. 2. **Neurodegenerative Disorders**: ECPAS dysfunction has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, underscoring the importance of ECPAS in maintaining neuronal homeostasis. 3. **Muscular Dystrophy**: ECPAS dysfunction has been linked to muscular dystrophy, highlighting the importance of ECPAS in maintaining muscle homeostasis. In conclusion, ECPAS is a critical component in maintaining cellular homeostasis and regulating protein degradation and trafficking. Dysregulation of ECPAS has significant clinical implications, particularly in the context of cancer, neurodegenerative disorders, and muscular dystrophy. Further research is needed to fully elucidate the function of ECPAS and its role in maintaining cellular homeostasis.

Genular Protein ID: 1351176012

Symbol: ECM29_HUMAN

Name: Proteasome-associated protein ECM29 homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 15496406

Title: Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles.

PubMed ID: 15496406

DOI: 10.1074/jbc.m410444200

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

Sequence Information:

  • Length: 1845
  • Mass: 204291
  • Checksum: 5809A9208F5B4441
  • Sequence:
  • MAAAAASASQ DELNQLERVF LRLGHAETDE QLQNIISKFL PPVLLKLSST QEGVRKKVME 
    LLVHLNKRIK SRPKIQLPVE TLLVQYQDPA AVSFVTNFTI IYVKMGYPRL PVEKQCELAP 
    TLLTAMEGKP QPQQDSLMHL LIPTLFHMKY PVESSKSASP FNLAEKPKTV QLLLDFMLDV 
    LLMPYGYVLN ESQSRQNSSS AQGSSSNSGG GSGIPQPPPG MSFYAAKRVI GDNPWTPEQL 
    EQCKLGIVKF IEAEQVPELE AVLHLVIASS DTRHSVATAA DLELKSKQSL IDWNNPAIIN 
    KMYKVYLGDI PLKTKEGAVL KPELKRDPVS TRVKLKIVPH LLRSRQAAET FPANIQVVYD 
    GLFGTNTNSK LRTLSLQFVH HICITCPEIK IKPLGPMLLN GLTKLINEYK EDPKLLSMAY 
    SAVGKLSSRM PHLFTKDIAL VQQLFEALCK EEPETRLAIQ EALSMMVGAY STLEGAQRTL 
    MEALVASYLI KPEVQVRQVA VKFASTVFPS DHIPSRYLLL LAAGDPREEV HGEAQRVLRC 
    LPGRNRKEST SEQMPSFPEM VYYIQEKASH RMKTPVKYMT GTTVLPFNPA AFGEIVLYLR 
    MCLAHSAGVV PTSQSLADMQ DHAPAIGRYI RTLMSSGQMA PSSSNKSGET NPVQIYIGLL 
    QQLLAGVGGL PVMYCLLEAV SVYPEKLATK FVDKTEWIKS LMNNSKEEMR ELAALFYSVV 
    VSTVSGNELK SMIEQLIKTT KDNHSPEIQH GSLLALGFTV GRYLAKKKMR MSEQQDLERN 
    ADTLPDQEEL IQSATETIGS FLDSTSPLLA IAACTALGEI GRNGPLPIPS EGSGFTKLHL 
    VESLLSRIPS SKETNKMKER AIQTLGYFPV GDGDFPHQKL LLQGLMDSVE AKQIELQFTI 
    GEAITSAAIG TSSVAARDAW QMTEEEYTPP AGAKVNDVVP WVLDVILNKH IISPNPHVRQ 
    AACIWLLSLV RKLSTHKEVK SHLKEIQSAF VSVLSENDEL SQDVASKGLG LVYELGNEQD 
    QQELVSTLVE TLMTGKRVKH EVSGETVVFQ GGALGKTPDG QGLSTYKELC SLASDLSQPD 
    LVYKFMNLAN HHAMWNSRKG AAFGFNVIAT RAGEQLAPFL PQLVPRLYRY QFDPNLGIRQ 
    AMTSIWNALV TDKSMVDKYL KEILQDLVKN LTSNMWRVRE SSCLALNDLL RGRPLDDIID 
    KLPEIWETLF RVQDDIKESV RKAAELALKT LSKVCVKMCD PAKGAAGQRT IAALLPCLLD 
    KGMMSTVTEV RALSINTLVK ISKSAGAMLK PHAPKLIPAL LESLSVLEPQ VLNYLSLRAT 
    EQEKAAMDSA RLSAAKSSPM METINMCLQY LDVSVLGELV PRLCELIRSG VGLGTKGGCA 
    SVIVSLTTQC PQDLTPYSGK LMSALLSGLT DRNSVIQKSC AFAMGHLVRT SRDSSTEKLL 
    QKLNGWYMEK EEPIYKTSCA LTIHAIGRYS PDVLKNHAKE VLPLAFLGMH EIADEEKSEK 
    EECNLWTEVW QENVPGSFGG IRLYLQELIT ITQKALQSQS WKMKAQGAIA MASIAKQTSS 
    LVPPYLGMIL TALLQGLAGR TWAGKEELLK AIACVVTACS AELEKSVPNQ PSTNEILQAV 
    LKECSKENVK YKIVAISCAA DILKATKEDR FQEFSNIVIP LIKKNSLESS GVRTTKNEEE 
    NEKEKELQLE YLLGAFESLG KAWPRNAETQ RCYRQELCKL MCERLKLSTW KVQLGVLQSM 
    NAFFQGLMLL EEEHADPEAL AEILLETCKS ITYSLENKTY SSVRTEALSV IELLLKKLEE 
    SKQWECLTSE CRVLLIESLA TMEPDSRPEL QEKAALLKKT LENLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.