Details for: PIP5K1C

Gene ID: 23396

Symbol: PIP5K1C

Ensembl ID: ENSG00000186111

Description: phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

Associated with

Other Information

Genular Protein ID: 4060623328

Symbol: PI51C_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19548880

Title: Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting.

PubMed ID: 19548880

DOI: 10.1042/bj20090638

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 12422219

Title: Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.

PubMed ID: 12422219

DOI: 10.1038/nature01147

PubMed ID: 12847086

Title: ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.

PubMed ID: 12847086

DOI: 10.1083/jcb.200301006

PubMed ID: 15738269

Title: Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases.

PubMed ID: 15738269

DOI: 10.1083/jcb.200409028

PubMed ID: 17261850

Title: Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.

PubMed ID: 17261850

DOI: 10.1083/jcb.200606023

PubMed ID: 17635937

Title: Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration.

PubMed ID: 17635937

DOI: 10.1083/jcb.200701078

PubMed ID: 20668706

Title: SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kgamma activity through deacetylation of specific lysine residues in mammals.

PubMed ID: 20668706

DOI: 10.1371/journal.pone.0011755

PubMed ID: 19889969

Title: PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.

PubMed ID: 19889969

DOI: 10.1242/jcs.056127

PubMed ID: 22942276

Title: Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.

PubMed ID: 22942276

DOI: 10.1074/jbc.m112.370155

PubMed ID: 25588945

Title: LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.

PubMed ID: 25588945

DOI: 10.15252/embj.201489425

PubMed ID: 17701898

Title: Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI gamma of the phophatidylinositol pathway.

PubMed ID: 17701898

DOI: 10.1086/520771

Sequence Information:

  • Length: 668
  • Mass: 73260
  • Checksum: 45A9FB32B4E43083
  • Sequence:
  • MELEVPDEAE SAEAGAVPSE AAWAAESGAA AGLAQKKAAP TEVLSMTAQP GPGHGKKLGH 
    RGVDASGETT YKKTTSSTLK GAIQLGIGYT VGHLSSKPER DVLMQDFYVV ESIFFPSEGS 
    NLTPAHHFQD FRFKTYAPVA FRYFRELFGI RPDDYLYSLC NEPLIELSNP GASGSLFYVT 
    SDDEFIIKTV MHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG KNIRVVVMNN 
    ILPRVVKMHL KFDLKGSTYK RRASKKEKEK SFPTYKDLDF MQDMPEGLLL DADTFSALVK 
    TLQRDCLVLE SFKIMDYSLL LGVHNIDQHE RERQAQGAQS TSDEKRPVGQ KALYSTAMES 
    IQGGAARGEA IESDDTMGGI PAVNGRGERL LLHIGIIDIL QSYRFIKKLE HTWKALVHDG 
    DTVSVHRPSF YAERFFKFMS NTVFRKNSSL KSSPSKKGRG GALLAVKPLG PTAAFSASQI 
    PSEREEAQYD LRGARSYPTL EDEGRPDLLP CTPPSFEEAT TASIATTLSS TSLSIPERSP 
    SETSEQPRYR RRTQSSGQDG RPQEEPPAEE DLQQITVQVE PACSVEIVVP KEEDAGVEAS 
    PAGASAAVEV ETASQASDEE GAPASQASDE EDAPATDIYF PTDERSWVYS PLHYSAQAPP 
    ASDGESDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.