Details for: DICER1
Associated with
Other Information
Genular Protein ID: 362883320
Symbol: DICER_HUMAN
Name: Endoribonuclease Dicer
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10786632
Title: Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase.
PubMed ID: 10786632
PubMed ID: 20615407
Title: A novel splice variant of the human dicer gene is expressed in neuroblastoma cells.
PubMed ID: 20615407
PubMed ID: 10231032
Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10231032
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10051563
Title: Interaction of 5-lipoxygenase with cellular proteins.
PubMed ID: 10051563
PubMed ID: 15242644
Title: Single processing center models for human Dicer and bacterial RNase III.
PubMed ID: 15242644
PubMed ID: 14749716
Title: Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.
PubMed ID: 14749716
PubMed ID: 16271387
Title: Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.
PubMed ID: 16271387
PubMed ID: 16289642
Title: Identification of novel argonaute-associated proteins.
PubMed ID: 16289642
PubMed ID: 16142218
Title: TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.
PubMed ID: 16142218
PubMed ID: 16357216
Title: A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.
PubMed ID: 16357216
DOI: 10.1101/gad.1384005
PubMed ID: 15973356
Title: TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.
PubMed ID: 15973356
DOI: 10.1038/nature03868
PubMed ID: 16424907
Title: The role of PACT in the RNA silencing pathway.
PubMed ID: 16424907
PubMed ID: 17452327
Title: Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.
PubMed ID: 17452327
PubMed ID: 17531811
Title: RNA helicase A interacts with RISC in human cells and functions in RISC loading.
PubMed ID: 17531811
PubMed ID: 17507929
Title: MicroRNA silencing through RISC recruitment of eIF6.
PubMed ID: 17507929
DOI: 10.1038/nature05841
PubMed ID: 18690212
Title: Prolyl 4-hydroxylation regulates Argonaute 2 stability.
PubMed ID: 18690212
DOI: 10.1038/nature07186
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18178619
Title: In vitro reconstitution of the human RISC-loading complex.
PubMed ID: 18178619
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19022417
Title: Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.
PubMed ID: 19022417
PubMed ID: 19219043
Title: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
PubMed ID: 19219043
DOI: 10.1038/ng.317
PubMed ID: 26813765
Title: Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
PubMed ID: 26813765
DOI: 10.1038/ng0216-221
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21882293
Title: Extending the phenotypes associated with DICER1 mutations.
PubMed ID: 21882293
DOI: 10.1002/humu.21600
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 21228243
Title: Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway.
PubMed ID: 21228243
DOI: 10.1128/jvi.01160-10
PubMed ID: 23063121
Title: Human RNA methyltransferase BCDIN3D regulates microRNA processing.
PubMed ID: 23063121
PubMed ID: 22187960
Title: Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.
PubMed ID: 22187960
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17920623
Title: Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer.
PubMed ID: 17920623
PubMed ID: 19556464
Title: DICER1 mutations in familial pleuropulmonary blastoma.
PubMed ID: 19556464
PubMed ID: 21205968
Title: DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
PubMed ID: 21205968
PubMed ID: 24676357
Title: Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
PubMed ID: 24676357
Sequence Information:
- Length: 1922
- Mass: 218682
- Checksum: 9452B96A601D4551
- Sequence:
MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT IVCLNTGSGK TFIAVLLTKE LSYQIRGDFS RNGKRTVFLV NSANQVAQQV SAVRTHSDLK VGEYSNLEVN ASWTKERWNQ EFTKHQVLIM TCYVALNVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM KLCENCPSCP RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT FLRKIHALCE EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDE DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR NKQMEAEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP TEYRSYVQSK GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGETD IDPVMDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD GTFYSTLYLP INSPLRASIV GPPMSCVRLA ERVVALICCE KLHKIGELDD HLMPVGKETV KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRDS YPRPDQPCYL YVIGMVLTTP LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFMLSL QMLELITRLH QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI EKSEARIGIP STKYTKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPADFR YPNLDFGWKK SIDSKSFISI SNSSSAENDN YCKHSTIVPE NAAHQGANRT SSLENHDQMS VNCRTLLSES PGKLHVEVSA DLTAINGLSY NQNLANGSYD LANRDFCQGN QLNYYKQEIP VQPTTSYSIQ NLYSYENQPQ PSDECTLLSN KYLDGNANKS TSDGSPVMAV MPGTTDTIQV LKGRMDSEQS PSIGYSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD SFLKHAITTY LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD KSNTDKWEKD EMTKDCMLAN GKLDEDYEEE DEEEESLMWR APKEEADYED DFLEYDQEHI RFIDNMLMGS GAFVKKISLS PFSTTDSAYE WKMPKKSSLG SMPFSSDFED FDYSSWDAMC YLDPSKAVEE DDFVVGFWNP SEENCGVDTG KQSISYDLHT EQCIADKSIA DCVEALLGCY LTSCGERAAQ LFLCSLGLKV LPVIKRTDRE KALCPTRENF NSQQKNLSVS CAAASVASSR SSVLKDSEYG CLKIPPRCMF DHPDADKTLN HLISGFENFE KKINYRFKNK AYLLQAFTHA SYHYNTITDC YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV NNTIFASLAV KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE DIEVPKAMGD IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP RSPVRELLEM EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA KSAAARRALR SLKANQPQVP NS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.