Associated with
Other Information
Genular Protein ID: 1268778502
Symbol: SIR5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10381378
Title: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
PubMed ID: 10381378
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16079181
Title: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
PubMed ID: 16079181
PubMed ID: 18680753
Title: Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
PubMed ID: 18680753
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21143562
Title: Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms.
PubMed ID: 21143562
PubMed ID: 21908771
Title: The first identification of lysine malonylation substrates and its regulatory enzyme.
PubMed ID: 21908771
PubMed ID: 23028781
Title: Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
PubMed ID: 23028781
PubMed ID: 24140062
Title: SIRT5 desuccinylates and activates SOD1 to eliminate ROS.
PubMed ID: 24140062
PubMed ID: 23438705
Title: Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
PubMed ID: 23438705
PubMed ID: 23806337
Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
PubMed ID: 23806337
PubMed ID: 24703693
Title: Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
PubMed ID: 24703693
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29180469
Title: SHMT2 desuccinylation by SIRT5 drives cancer cell proliferation.
PubMed ID: 29180469
PubMed ID: 17355872
Title: Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.
PubMed ID: 17355872
PubMed ID: 22076378
Title: Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
PubMed ID: 22076378
PubMed ID: 22767592
Title: The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5).
PubMed ID: 22767592
PubMed ID: 22849721
Title: Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5.
PubMed ID: 22849721
DOI: 10.1021/jo301067e
PubMed ID: 23185430
Title: A molecular mechanism for direct sirtuin activation by resveratrol.
PubMed ID: 23185430
Sequence Information:
- Length: 310
- Mass: 33881
- Checksum: 022DA32CDB43AC3A
- Sequence:
MRPLQIVPSR LISQLYCGLK PPASTRNQIC LKMARPSSSM ADFRKFFAKA KHIVIISGAG VSAESGVPTF RGAGGYWRKW QAQDLATPLA FAHNPSRVWE FYHYRREVMG SKEPNAGHRA IAECETRLGK QGRRVVVITQ NIDELHRKAG TKNLLEIHGS LFKTRCTSCG VVAENYKSPI CPALSGKGAP EPGTQDASIP VEKLPRCEEA GCGGLLRPHV VWFGENLDPA ILEEVDRELA HCDLCLVVGT SSVVYPAAMF APQVAARGVP VAEFNTETTP ATNRFRFHFQ GPCGTTLPEA LACHENETVS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.