SIRT4 | ENSG00000089163 | NCBI 23409

Details for: SIRT4

Gene ID: 23409

Symbol: SIRT4

Ensembl ID: ENSG00000089163

Description: sirtuin 4

Associated with

Mitochondrial biogenesis
(R-HSA-1592230)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Cellular response to hypoxia
(GO:0071456)
Chromatin remodeling
(GO:0006338)
Dna damage response
(GO:0006974)
Glutamine metabolic process
(GO:0006541)
Histone deacetylase activity
(GO:0004407)
Lipoamidase activity
(GO:0061690)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Nad+- protein-cysteine adp-ribosyltransferase activity
(GO:0140803)
Nad+-protein adp-ribosyltransferase activity
(GO:1990404)
Nad+ adp-ribosyltransferase activity
(GO:0003950)
Nad+ binding
(GO:0070403)
Nad-dependent protein biotinidase activity
(GO:0106420)
Nad-dependent protein deacetylase activity
(GO:0034979)
Nad-dependent protein lipoamidase activity
(GO:0106419)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of fatty acid oxidation
(GO:0046322)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of protein processing involved in protein targeting to mitochondrion
(GO:1903217)
Nucleotidyltransferase activity
(GO:0016779)
Peptidyl-lysine deacetylation
(GO:0034983)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Protein binding
(GO:0005515)
Regulation of glutamine family amino acid metabolic process
(GO:0000820)
Regulation of pyruvate dehydrogenase activity
(GO:1904182)
Tricarboxylic acid metabolic process
(GO:0072350)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

SIR4_HUMAN

Genular Protein ID: 3009180984

Symbol: SIR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6E7 O43346 Q32M33

Database IDs:

Citations:

PubMed ID: 10381378

Title: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.

PubMed ID: 10381378

DOI: 10.1006/bbrc.1999.0897

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959573

Title: SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

PubMed ID: 16959573

DOI: 10.1016/j.cell.2006.06.057

PubMed ID: 17715127

Title: Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.

PubMed ID: 17715127

DOI: 10.1074/jbc.m705488200

PubMed ID: 16079181

Title: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

PubMed ID: 16079181

DOI: 10.1091/mbc.e05-01-0033

PubMed ID: 23562301

Title: SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

PubMed ID: 23562301

DOI: 10.1016/j.ccr.2013.02.024

PubMed ID: 23663782

Title: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

PubMed ID: 23663782

DOI: 10.1016/j.cell.2013.04.023

PubMed ID: 23438705

Title: Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

PubMed ID: 23438705

DOI: 10.1016/j.mito.2013.02.002

PubMed ID: 24043310

Title: SIRT4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation.

PubMed ID: 24043310

DOI: 10.1128/mcb.00087-13

PubMed ID: 24052263

Title: Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

PubMed ID: 24052263

DOI: 10.1074/jbc.c113.511261

PubMed ID: 25525879

Title: Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.

PubMed ID: 25525879

DOI: 10.1016/j.cell.2014.11.046

Sequence Information:

Length: 314
Mass: 35188
Checksum: 2B76963AD2C3B354
Sequence:

MKMSFALTFR SAKGRWIANP SQPCSKASIG LFVPASPPLD PEKVKELQRF ITLSKRLLVM 
TGAGISTESG IPDYRSEKVG LYARTDRRPI QHGDFVRSAP IRQRYWARNF VGWPQFSSHQ 
PNPAHWALST WEKLGKLYWL VTQNVDALHT KAGSRRLTEL HGCMDRVLCL DCGEQTPRGV 
LQERFQVLNP TWSAEAHGLA PDGDVFLSEE QVRSFQVPTC VQCGGHLKPD VVFFGDTVNP 
DKVDFVHKRV KEADSLLVVG SSLQVYSGYR FILTAWEKKL PIAILNIGPT RSDDLACLKL 
NSRCGELLPL IDPC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SIRT4

Associated with

Other Information

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. PubMed ID: 10381378

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. PubMed ID: 16959573

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. PubMed ID: 17715127

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. PubMed ID: 16079181

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. PubMed ID: 23562301

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. PubMed ID: 23663782

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. PubMed ID: 23438705

SIRT4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation. PubMed ID: 24043310

Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. PubMed ID: 24052263

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. PubMed ID: 25525879