Associated with
Other Information
Genular Protein ID: 982760157
Symbol: SIR3_HUMAN
Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10381378
Title: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
PubMed ID: 10381378
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12186850
Title: The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.
PubMed ID: 12186850
PubMed ID: 12374852
Title: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
PubMed ID: 12374852
PubMed ID: 16079181
Title: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
PubMed ID: 16079181
PubMed ID: 16788062
Title: Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.
PubMed ID: 16788062
PubMed ID: 18215119
Title: The human SIRT3 protein deacetylase is exclusively mitochondrial.
PubMed ID: 18215119
DOI: 10.1042/bj20071624
PubMed ID: 18680753
Title: Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
PubMed ID: 18680753
PubMed ID: 18794531
Title: A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
PubMed ID: 18794531
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21172655
Title: Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
PubMed ID: 21172655
PubMed ID: 23283301
Title: A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
PubMed ID: 23283301
PubMed ID: 24121500
Title: SIRT3 regulates long-chain acyl-coA dehydrogenase by deacetylating conserved lysines near the active site.
PubMed ID: 24121500
PubMed ID: 23438705
Title: Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
PubMed ID: 23438705
PubMed ID: 24252090
Title: SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient and exercise-induced stress.
PubMed ID: 24252090
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29445193
Title: Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
PubMed ID: 29445193
PubMed ID: 19535340
Title: Crystal structures of human SIRT3 displaying substrate-induced conformational changes.
PubMed ID: 19535340
PubMed ID: 23897466
Title: Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.
PubMed ID: 23897466
Sequence Information:
- Length: 399
- Mass: 43573
- Checksum: 4BA8BD3AC5FC7901
- Sequence:
MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL RGSHGARGEP LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR SISFSVGASS VVGSGGSSDK GKLSLQDVAE LIRARACQRV VVMVGAGIST PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF ELPFFFHNPK PFFTLAKELY PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP ASKLVEAHGT FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP LAWHPRSRDV AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.