Genular: Defining Cellular Identity and Function

Details for: KCNH3

Gene ID: 23416

Symbol: KCNH3

Ensembl ID: ENSG00000135519

Description: potassium voltage-gated channel subfamily H member 3

Associated with

Neuronal system
(R-HSA-112316)
Potassium channels
(R-HSA-1296071)
Voltage gated potassium channels
(R-HSA-1296072)
Membrane
(GO:0016020)
Monoatomic ion channel complex
(GO:0034702)
Plasma membrane
(GO:0005886)
Potassium ion transmembrane transport
(GO:0071805)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Regulation of membrane potential
(GO:0042391)
Voltage-gated potassium channel activity
(GO:0005249)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.84
Marker Score: 32,457
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.1
Marker Score: 4,348
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,170
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.61
Marker Score: 13,815
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.56
Marker Score: 14,799
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.54
Marker Score: 1,531
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169,417
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.45
Marker Score: 89,121
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.44
Marker Score: 2,222
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.41
Marker Score: 2,374
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.29
Marker Score: 12,162
Cell Name: acinar cell (CL0000622)
Fold Change: 1.23
Marker Score: 865
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.16
Marker Score: 42,741
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,816
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.11
Marker Score: 707
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.01
Marker Score: 685
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,826
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,051
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.95
Marker Score: 394
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,348
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.88
Marker Score: 404
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.85
Marker Score: 13,376
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 626
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,262
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.73
Marker Score: 14,605
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.7
Marker Score: 1,320
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.66
Marker Score: 436
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.6
Marker Score: 5,192
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 374
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 460
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.54
Marker Score: 1,873
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.54
Marker Score: 1,277
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.53
Marker Score: 221
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.52
Marker Score: 4,022
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.52
Marker Score: 2,010
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.52
Marker Score: 7,723
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.48
Marker Score: 980
Cell Name: goblet cell (CL0000160)
Fold Change: 0.47
Marker Score: 3,131
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.47
Marker Score: 1,336
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.45
Marker Score: 16,935
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.43
Marker Score: 1,079
Cell Name: neuron (CL0000540)
Fold Change: 0.41
Marker Score: 1,649
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.4
Marker Score: 768
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.37
Marker Score: 221
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.37
Marker Score: 1,517
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.34
Marker Score: 107
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.32
Marker Score: 155
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.32
Marker Score: 550
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.31
Marker Score: 83
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 303
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.28
Marker Score: 218
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.28
Marker Score: 132
Cell Name: podocyte (CL0000653)
Fold Change: 0.25
Marker Score: 94
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.25
Marker Score: 227
Cell Name: interneuron (CL0000099)
Fold Change: 0.25
Marker Score: 112
Cell Name: astrocyte (CL0000127)
Fold Change: 0.24
Marker Score: 211
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.24
Marker Score: 74
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.23
Marker Score: 75
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.23
Marker Score: 151
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.23
Marker Score: 67
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.23
Marker Score: 4,838
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.23
Marker Score: 800
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.22
Marker Score: 936
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.22
Marker Score: 102
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.22
Marker Score: 92
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.2
Marker Score: 105
Cell Name: neutrophil (CL0000775)
Fold Change: 0.2
Marker Score: 123
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.2
Marker Score: 117
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.2
Marker Score: 52
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.2
Marker Score: 47
Cell Name: germ cell (CL0000586)
Fold Change: 0.2
Marker Score: 349
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 113
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.2
Marker Score: 81
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.19
Marker Score: 4,348
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.19
Marker Score: 197
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.19
Marker Score: 190
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.18
Marker Score: 51
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.18
Marker Score: 261
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.18
Marker Score: 255
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.17
Marker Score: 1,037
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.17
Marker Score: 197
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.17
Marker Score: 203
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.17
Marker Score: 176
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.16
Marker Score: 74

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Gene Location and Expression:** The KCNH3 gene is located on chromosome 12q13.12 and is expressed in a wide range of cell types, including retinal bipolar neurons, kidney proximal convoluted tubule epithelial cells, and colon goblet cells. 2. **Protein Structure:** The KCNH3 protein is a voltage-gated potassium channel subunit, consisting of six transmembrane domains and a pore region. 3. **Function:** KCNH3 functions as a potassium channel, allowing potassium ions to flow out of the cell, which helps to regulate membrane potential and maintain cellular homeostasis. **Pathways and Functions:** 1. **Potassium Channel Activity:** KCNH3 is a key component of voltage-gated potassium channels, which play a crucial role in regulating membrane potential and maintaining cellular homeostasis. 2. **Neuronal System:** In the nervous system, KCNH3 is expressed in retinal bipolar neurons, where it helps to regulate light-dependent membrane potential and neurotransmitter release. 3. **Regulation of Membrane Potential:** KCNH3 helps to regulate membrane potential by allowing potassium ions to flow out of the cell, which helps to maintain cellular homeostasis and prevent excessive excitability. 4. **Protein Binding:** KCNH3 interacts with other proteins, such as KCNQ1 and KCNE1, to form functional potassium channels. **Clinical Significance:** 1. **Genetic Disorders:** Mutations in the KCNH3 gene have been associated with genetic disorders, such as long QT syndrome, which can increase the risk of arrhythmias and sudden cardiac death. 2. **Neurological Disorders:** KCNH3 has been implicated in various neurological disorders, including epilepsy and migraines, where its dysregulation can lead to abnormal membrane potential and neuronal excitability. 3. **Pharmacological Applications:** KCNH3 has been targeted by pharmacological agents, such as anti-arrhythmic medications, to regulate potassium channel activity and prevent arrhythmias. 4. **Cancer Research:** KCNH3 has been identified as a potential target for cancer therapy, where its dysregulation can contribute to cancer cell proliferation and survival. In conclusion, the KCNH3 gene plays a critical role in regulating membrane potential and ion transport across various cell types. Its dysregulation has been implicated in genetic disorders, neurological disorders, and cancer. Further research is needed to fully elucidate the immunological significance of KCNH3 and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Potassium voltage-gated channel subfamily H member 3

Genular Protein ID: 2971604056

Symbol: KCNH3_HUMAN

Name: Potassium voltage-gated channel subfamily H member 3

UniProtKB Accession Codes:

Q9ULD8 Q9UQ06

Database IDs:

Citations:

PubMed ID: 10455180

Title: New ether-a-go-go K+ channel family members localized in human telencephalon.

PubMed ID: 10455180

DOI: 10.1074/jbc.274.35.25018

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

Sequence Information:

Length: 1083
Mass: 117129
Checksum: EF35C8968D7418CC
Sequence:

MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC DLTGFSRAEV 
MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY RKSGLPFWCL LDVIPIKNEK 
GEVALFLVSH KDISETKNRG GPDRWKETGG GRRRYGRARS KGFNANRRRS RAVLYHLSGH 
LQKQPKGKHK LNKGVFGEKP NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV 
TVPYSVCVST AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 
HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD RYSQYSAVVL 
TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ ELARRLETPY YLVGRRPAGG 
NSSGQSDNCS SSSEANGTGL ELLGGPSLRS AYITSLYFAL SSLTSVGFGN VSANTDTEKI 
FSICTMLIGA LMHAVVFGNV TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE 
YFQATWAVNN GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP 
AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP RREQVVKANA 
DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL SYNLGAGGGS AEVDTSSLSG 
DNTLMSTLEE KETDGEQGPT VSPAPADEPS SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG 
GRGRPGRAGA LKAEAGPSAP PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS 
FRVGQSGPEC SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ 
SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ PPAGSVLSGT 
WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS EPPASGDLCS EPSTPASPPP 
SEEGARTGPA EPVSQAEATS TGEPPPGSGG LALPWDPHSL EMVLIGCHGS GTVQWTQEEG 
TGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.