Details for: SLC7A8
Associated with
Other Information
Genular Protein ID: 4190504717
Symbol: LAT2_HUMAN
Name: Large neutral amino acids transporter small subunit 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10391915
Title: Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.
PubMed ID: 10391915
PubMed ID: 10574970
Title: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.
PubMed ID: 10574970
PubMed ID: 10080183
Title: SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance.
PubMed ID: 10080183
DOI: 10.1038/6815
PubMed ID: 15918515
Title: Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.
PubMed ID: 15918515
DOI: 10.1007/bf02977671
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11311135
Title: Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
PubMed ID: 11311135
DOI: 10.1042/bj3550725
PubMed ID: 12117417
Title: Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.
PubMed ID: 12117417
DOI: 10.1042/bj20020841
PubMed ID: 11847106
Title: Activation of system L heterodimeric amino acid exchangers by intracellular substrates.
PubMed ID: 11847106
PubMed ID: 12716892
Title: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia.
PubMed ID: 12716892
PubMed ID: 15081149
Title: Identification and functional characterization of a Na(+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells.
PubMed ID: 15081149
PubMed ID: 16027961
Title: Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells.
PubMed ID: 16027961
PubMed ID: 15769744
Title: Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.
PubMed ID: 15769744
PubMed ID: 29355479
Title: Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss.
PubMed ID: 29355479
DOI: 10.7554/elife.31511
PubMed ID: 33066406
Title: The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2.
PubMed ID: 33066406
DOI: 10.3390/ijms21207573
PubMed ID: 33298890
Title: Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
PubMed ID: 33298890
PubMed ID: 34848541
Title: Structural basis for substrate specificity of heteromeric transporters of neutral amino acids.
PubMed ID: 34848541
Sequence Information:
- Length: 535
- Mass: 58382
- Checksum: AC129146353F1E47
- Sequence:
MEEGARHRNN TEKKHPGGGE SDASPEAGSG GGGVALKKEI GLVSACGIIV GNIIGSGIFV SPKGVLENAG SVGLALIVWI VTGFITVVGA LCYAELGVTI PKSGGDYSYV KDIFGGLAGF LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL FPTCFPPESG LRLLAAICLL LLTWVNCSSV RWATRVQDIF TAGKLLALAL IIIMGIVQIC KGEYFWLEPK NAFENFQEPD IGLVALAFLQ GSFAYGGWNF LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VFANVAYVTA MSPQELLASN AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL PSVLAMIHVK RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYLFYG VTVAGQIVLR WKKPDIPRPI KINLLFPIIY LLFWAFLLVF SLWSEPVVCG IGLAIMLTGV PVYFLGVYWQ HKPKCFSDFI ELLTLVSQKM CVVVYPEVER GSGTEEANED MEEQQQPMYQ PTPTKDKDVA GQPQP
Genular Protein ID: 813855677
Symbol: Q53EM9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8125298
Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
PubMed ID: 8125298
PubMed ID: 9373149
Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
PubMed ID: 9373149
Sequence Information:
- Length: 535
- Mass: 58362
- Checksum: AC0F4A4BAE245E47
- Sequence:
MEEGARHRNN TEKKHPGGGE SDASPEAGSG GGGVALKKEI GLVSACGIIV GNIIGSGIFV SPKGVLENAG SVGLALIVWI VTGFITVVGA LCYAELGVTI PKSGGDYSYV KDIFGGLAGF LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL FPTCFPPESG LRLLAAICLL LLTWVNCSSV RWATRVQDIF TAGKLLALAL IIIMGIVQIC KGEYFWLEPK NAFENFQEPD IGLVALAFLQ GSFAYGGWNF LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VVANVAYVTA MSPQELLASN AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL PSVLAMIHVK RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYLFYG VTVVGQIVLR WKKPDIPRPI KINLLFPIIY LLFWAFLLVF SLWSEPVVCG IGLAIMLTGV PVYFLGVYWQ HKPKCFSDFI ELLTLVSQKM CVVVYPEVER GSGTEEANED MEEQQQPMYQ PTPTKDKDVA GQPQP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.