RYBP | ENSG00000163602 | NCBI 23429

Details for: RYBP

Gene ID: 23429

Symbol: RYBP

Ensembl ID: ENSG00000163602

Description: RING1 and YY1 binding protein

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by runx1
(R-HSA-8878171)
Apoptotic process
(GO:0006915)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Metal ion binding
(GO:0046872)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032435)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)

Other Information

Proteins

RING1 and YY1-binding protein

Genular Protein ID: 1267420839

Symbol: RYBP_HUMAN

Name: RING1 and YY1-binding protein

UniProtKB Accession Codes:

Q8N488 Q9P2W5 Q9UMW4

Database IDs:

Citations:

PubMed ID: 11395500

Title: The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.

PubMed ID: 11395500

DOI: 10.1074/jbc.m102799200

PubMed ID: 11953439

Title: YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.

PubMed ID: 11953439

DOI: 10.1074/jbc.m203060200

PubMed ID: 14765135

Title: Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing.

PubMed ID: 14765135

DOI: 10.1038/sj.cdd.4401391

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16943429

Title: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.

PubMed ID: 16943429

DOI: 10.1128/mcb.00630-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19098711

Title: RYBP stabilizes p53 by modulating MDM2.

PubMed ID: 19098711

DOI: 10.1038/embor.2008.231

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25519132

Title: An AUTS2-polycomb complex activates gene expression in the CNS.

PubMed ID: 25519132

DOI: 10.1038/nature13921

PubMed ID: 26687479

Title: The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PubMed ID: 26687479

DOI: 10.1038/srep18388

PubMed ID: 27060496

Title: Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway.

PubMed ID: 27060496

DOI: 10.1016/j.cellsig.2016.03.012

PubMed ID: 27748911

Title: RING1 and YY1 binding protein suppresses breast cancer growth and metastasis.

PubMed ID: 27748911

DOI: 10.3892/ijo.2016.3718

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20696397

Title: Polycomb group targeting through different binding partners of RING1B C-terminal domain.

PubMed ID: 20696397

DOI: 10.1016/j.str.2010.04.013

Sequence Information:

Length: 228
Mass: 24822
Checksum: EB9593460A3F0F4C
Sequence:

MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ 
LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP SVTKKNTNKK TKPKSDILKD 
PPSEANSIQS ANATTKTSET NHTSRPRLKN VDRSTAQQLA VTVGNVTVII TDFKEKTRSS 
STSSSTVTSS AGSEQQNQSS SGSESTDKGS SRSSTPKGDM SAVNDESF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RYBP

Associated with

Other Information

The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. PubMed ID: 11395500

YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. PubMed ID: 11953439

Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. PubMed ID: 14765135

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. PubMed ID: 16943429

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

RYBP stabilizes p53 by modulating MDM2. PubMed ID: 19098711

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An AUTS2-polycomb complex activates gene expression in the CNS. PubMed ID: 25519132

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. PubMed ID: 26687479

Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway. PubMed ID: 27060496

RING1 and YY1 binding protein suppresses breast cancer growth and metastasis. PubMed ID: 27748911

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Polycomb group targeting through different binding partners of RING1B C-terminal domain. PubMed ID: 20696397