HEY1 | ENSG00000164683 | NCBI 23462

Details for: HEY1

Gene ID: 23462

Symbol: HEY1

Ensembl ID: ENSG00000164683

Description: hes related family bHLH transcription factor with YRPW motif 1

Associated with

Cardiogenesis
(R-HSA-9733709)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates bone development
(R-HSA-8941326)
Runx2 regulates osteoblast differentiation
(R-HSA-8940973)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Angiogenesis
(GO:0001525)
Anterior/posterior pattern specification
(GO:0009952)
Aortic valve morphogenesis
(GO:0003180)
Arterial endothelial cell differentiation
(GO:0060842)
Atrioventricular valve formation
(GO:0003190)
Cardiac conduction system development
(GO:0003161)
Cardiac epithelial to mesenchymal transition
(GO:0060317)
Cardiac septum morphogenesis
(GO:0060411)
Cardiac ventricle morphogenesis
(GO:0003208)
Chromatin
(GO:0000785)
Circulatory system development
(GO:0072359)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dorsal aorta morphogenesis
(GO:0035912)
Endocardial cushion morphogenesis
(GO:0003203)
Heart trabecula formation
(GO:0060347)
Labyrinthine layer blood vessel development
(GO:0060716)
Negative regulation of biomineral tissue development
(GO:0070168)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of smooth muscle cell differentiation
(GO:0051151)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of neurogenesis
(GO:0050767)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of vasculogenesis
(GO:2001212)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Umbilical cord morphogenesis
(GO:0036304)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Hairy/enhancer-of-split related with YRPW motif protein 1
B4DEI9_HUMAN

Genular Protein ID: 1597998964

Symbol: HEY1_HUMAN

Name: Hairy/enhancer-of-split related with YRPW motif protein 1

UniProtKB Accession Codes:

Q9Y5J3 B2R883 Q5TZS3 Q8NAM2 Q9NYP4

Database IDs:

Citations:

PubMed ID: 10403790

Title: Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.

PubMed ID: 10403790

DOI: 10.1006/bbrc.1999.0880

PubMed ID: 10415358

Title: Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis.

PubMed ID: 10415358

DOI: 10.1016/s0925-4773(99)00080-5

PubMed ID: 10860664

Title: Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.

PubMed ID: 10860664

DOI: 10.1006/geno.2000.6200

PubMed ID: 10692439

Title: Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.

PubMed ID: 10692439

DOI: 10.1074/jbc.275.9.6381

PubMed ID: 11095750

Title: Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.

PubMed ID: 11095750

DOI: 10.1073/pnas.250485597

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15485867

Title: Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.

PubMed ID: 15485867

DOI: 10.1074/jbc.m409879200

PubMed ID: 25985737

Title: C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.

PubMed ID: 25985737

DOI: 10.1038/ncomms8122

PubMed ID: 26068074

Title: Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.

PubMed ID: 26068074

DOI: 10.1371/journal.pone.0130288

Sequence Information:

Length: 304
Mass: 32613
Checksum: F130991A99E9CA54
Sequence:

MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR KRRRGIIEKR 
RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH LKMLHTAGGK GYFDAHALAM 
DYRSLGFREC LAEVARYLSI IEGLDASDPL RVRLVSHLNN YASQREAASG AHAGLGHIPW 
GTVFGHHPHI AHPLLLPQNG HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSLGPV 
LPVVTSASKL SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE 
IGAF

Genular Protein ID: 3592082009

Symbol: B4DEI9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEI9

Database IDs:

Sequence Information:

Length: 214
Mass: 22610
Checksum: 669343686680E1AF
Sequence:

MPLEERNVFW LSKGNLTGDQ GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL 
RVRLVSHLNN YASQREAASG AHAGLGHIPW GTVFGHHPHI AHPLLLPQNG HGNAGTTASP 
TEPHHQGRLG SAHPEAPALR APPSGSLGPV LPVVTSASKL SPPLLSSVAS LSAFPFSFGS 
FHLLSPNALS PSAPTQAANL GKPYRPWGTE IGAF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HEY1

Associated with

Other Information

Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. PubMed ID: 10403790

Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis. PubMed ID: 10415358

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. PubMed ID: 10860664

Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. PubMed ID: 10692439

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. PubMed ID: 11095750

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. PubMed ID: 15485867

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. PubMed ID: 25985737

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus. PubMed ID: 26068074