HEY2 | ENSG00000135547 | NCBI 23493

Details for: HEY2

Gene ID: 23493

Symbol: HEY2

Ensembl ID: ENSG00000135547

Description: hes related family bHLH transcription factor with YRPW motif 2

Associated with

Cardiogenesis
(R-HSA-9733709)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates bone development
(R-HSA-8941326)
Runx2 regulates osteoblast differentiation
(R-HSA-8940973)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Anterior/posterior axis specification
(GO:0009948)
Anterior/posterior pattern specification
(GO:0009952)
Aortic valve morphogenesis
(GO:0003180)
Arterial endothelial cell differentiation
(GO:0060842)
Ascending aorta morphogenesis
(GO:0035910)
Atrial septum morphogenesis
(GO:0060413)
Cardiac conduction system development
(GO:0003161)
Cardiac epithelial to mesenchymal transition
(GO:0060317)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cardiac muscle cell apoptotic process
(GO:0010659)
Cardiac muscle cell proliferation
(GO:0060038)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cardiac septum morphogenesis
(GO:0060411)
Cardiac vascular smooth muscle cell development
(GO:0060948)
Cardiac ventricle morphogenesis
(GO:0003208)
Cell fate commitment
(GO:0045165)
Chromatin
(GO:0000785)
Circulatory system development
(GO:0072359)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cochlea development
(GO:0090102)
Coronary vasculature morphogenesis
(GO:0060977)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dorsal aorta morphogenesis
(GO:0035912)
Endocardial cushion to mesenchymal transition involved in heart valve formation
(GO:0003199)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Heart trabecula formation
(GO:0060347)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Labyrinthine layer blood vessel development
(GO:0060716)
Mesenchymal cell development
(GO:0014031)
Muscular septum morphogenesis
(GO:0003150)
Negative regulation of biomineral tissue development
(GO:0070168)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cardiac vascular smooth muscle cell differentiation
(GO:2000723)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of smooth muscle cell differentiation
(GO:0051151)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transcription initiation by rna polymerase ii
(GO:0060633)
Negative regulation of transcription regulatory region dna binding
(GO:2000678)
Notch signaling pathway
(GO:0007219)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-dna complex assembly
(GO:0065004)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Pulmonary artery morphogenesis
(GO:0061156)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of inner ear auditory receptor cell differentiation
(GO:0045607)
Regulation of neurogenesis
(GO:0050767)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of vasculogenesis
(GO:2001212)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smooth muscle cell differentiation
(GO:0051145)
Tricuspid valve formation
(GO:0003195)
Tricuspid valve morphogenesis
(GO:0003186)
Umbilical cord morphogenesis
(GO:0036304)
Vascular associated smooth muscle cell development
(GO:0097084)
Vasculogenesis
(GO:0001570)
Ventricular cardiac muscle cell development
(GO:0055015)
Ventricular septum morphogenesis
(GO:0060412)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Other Information

Proteins

Hairy/enhancer-of-split related with YRPW motif protein 2
Q5TF93_HUMAN

Genular Protein ID: 606751670

Symbol: HEY2_HUMAN

Name: Hairy/enhancer-of-split related with YRPW motif protein 2

UniProtKB Accession Codes:

Q9UBP5

Database IDs:

Citations:

PubMed ID: 10415358

Title: Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis.

PubMed ID: 10415358

DOI: 10.1016/s0925-4773(99)00080-5

PubMed ID: 10710309

Title: Gridlock, an HLH gene required for assembly of the aorta in zebrafish.

PubMed ID: 10710309

DOI: 10.1126/science.287.5459.1820

PubMed ID: 10692439

Title: Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.

PubMed ID: 10692439

DOI: 10.1074/jbc.275.9.6381

PubMed ID: 11095750

Title: Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.

PubMed ID: 11095750

DOI: 10.1073/pnas.250485597

PubMed ID: 11486044

Title: HERP, a new primary target of Notch regulated by ligand binding.

PubMed ID: 11486044

DOI: 10.1128/mcb.21.17.6071-6079.2001

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15485867

Title: Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.

PubMed ID: 15485867

DOI: 10.1074/jbc.m409879200

PubMed ID: 16293227

Title: CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6.

PubMed ID: 16293227

DOI: 10.1016/j.bbrc.2005.10.190

PubMed ID: 16329098

Title: HEY2 mutations in malformed hearts.

PubMed ID: 16329098

DOI: 10.1002/humu.9390

Sequence Information:

Length: 337
Mass: 35808
Checksum: 71B7B1AA69BA88D2
Sequence:

MKRPCEETTS ESDMDETIDV GSENNYSGQS TSSVIRLNSP TTTSQIMARK KRRGIIEKRR 
RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG YFDAHALAMD 
FMSIGFRECL TEVARYLSSV EGLDSSDPLR VRLVSHLSTC ATQREAAAMT SSMAHHHHPL 
HPHHWAAAFH HLPAALLQPN GLHASESTPC RLSTTSEVPP AHGSALLTAT FAHADSALRM 
PSTGSVAPCV PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP PNAAAAVAAA 
TAISPPLSVS ATSSPQQTSS GTNNKPYRPW GTEVGAF

Genular Protein ID: 3780365153

Symbol: Q5TF93_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TF93

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

Length: 291
Mass: 30799
Checksum: A7FB9B5784FF0BA5
Sequence:

MARKKRRGII EKRRRDRINN SLSELRRLVP TAFEKQGSAK LEKAEILQMT VDHLKMLQAT 
GGKGYFDAHA LAMDFMSIGF RECLTEVARY LSSVEGLDSS DPLRVRLVSH LSTCATQREA 
AAMTSSMAHH HHPLHPHHWA AAFHHLPAAL LQPNGLHASE STPCRLSTTS EVPPAHGSAL 
LTATFAHADS ALRMPSTGSV APCVPPLSTS LLSLSATVHA AAAAATAAAH SFPLSFAGAF 
PMLPPNAAAA VAAATAISPP LSVSATSSPQ QTSSGTNNKP YRPWGTEVGA F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HEY2

Associated with

Other Information

Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis. PubMed ID: 10415358

Gridlock, an HLH gene required for assembly of the aorta in zebrafish. PubMed ID: 10710309

Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. PubMed ID: 10692439

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. PubMed ID: 11095750

HERP, a new primary target of Notch regulated by ligand binding. PubMed ID: 11486044

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. PubMed ID: 15485867

CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. PubMed ID: 16293227

HEY2 mutations in malformed hearts. PubMed ID: 16329098

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Database document:

PubMed ID: 10415358

PubMed ID: 10710309

PubMed ID: 10692439

PubMed ID: 11095750

PubMed ID: 11486044

PubMed ID: 14574404

PubMed ID: 15489334

PubMed ID: 15485867

PubMed ID: 16293227

PubMed ID: 16329098

PubMed ID: 14574404