Details for: BICRAL

Gene ID: 23506

Symbol: BICRAL

Ensembl ID: ENSG00000112624

Description: BICRA like chromatin remodeling complex associated protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.68
    Marker Score: 62,311
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.44
    Marker Score: 18,669
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.4
    Marker Score: 47,792
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.4
    Marker Score: 35,862
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.37
    Marker Score: 89,953
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.23
    Marker Score: 82,388
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.21
    Marker Score: 9,168
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.21
    Marker Score: 47,183
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.21
    Marker Score: 1,291
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.2
    Marker Score: 1,070
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.13
    Marker Score: 9,838
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1
    Marker Score: 8,138
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.08
    Marker Score: 2,587
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.06
    Marker Score: 19,361
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.06
    Marker Score: 2,488
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.02
    Marker Score: 847
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.01
    Marker Score: 4,803
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2
    Marker Score: 2,299
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121,799
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.85
    Marker Score: 17,538
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.84
    Marker Score: 2,472
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15,428
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.78
    Marker Score: 3,903
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.77
    Marker Score: 4,425
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.72
    Marker Score: 3,315
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7
    Marker Score: 7,096
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7
    Marker Score: 17,506
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.66
    Marker Score: 1,837
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.66
    Marker Score: 965
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,435
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.58
    Marker Score: 500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.57
    Marker Score: 35,122
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.56
    Marker Score: 425
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.53
    Marker Score: 6,239
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.46
    Marker Score: 462
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.44
    Marker Score: 714
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.39
    Marker Score: 1,237
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.39
    Marker Score: 4,952
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2,778
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.37
    Marker Score: 3,896
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.35
    Marker Score: 395
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.34
    Marker Score: 724
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.31
    Marker Score: 907
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.3
    Marker Score: 1,240
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.3
    Marker Score: 779
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.29
    Marker Score: 772
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.29
    Marker Score: 1,458
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.28
    Marker Score: 3,007
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.2
    Marker Score: 375
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.19
    Marker Score: 1,466
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.18
    Marker Score: 380
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.18
    Marker Score: 1,981
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.17
    Marker Score: 654
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.16
    Marker Score: 1,252
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18,007
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.14
    Marker Score: 412
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.08
    Marker Score: 989
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.06
    Marker Score: 695
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.04
    Marker Score: 1,897
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.03
    Marker Score: 324
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.02
    Marker Score: 377
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,966
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.99
    Marker Score: 654
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.98
    Marker Score: 357
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.97
    Marker Score: 745
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.92
    Marker Score: 234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,718
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.89
    Marker Score: 5,355
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,993
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.84
    Marker Score: 436
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.84
    Marker Score: 170
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.84
    Marker Score: 466
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.82
    Marker Score: 434
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,274
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1,097
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.76
    Marker Score: 218
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3,150
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.75
    Marker Score: 357
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.74
    Marker Score: 928
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.74
    Marker Score: 191
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.69
    Marker Score: 235
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.69
    Marker Score: 181
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.68
    Marker Score: 250
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 666
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.66
    Marker Score: 697
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.65
    Marker Score: 227
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.65
    Marker Score: 197

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chromatin Remodeling Complex**: BICRAL is a component of the SWI/SNF complex, a chromatin remodeling complex that plays a crucial role in regulating gene expression by altering chromatin structure. 2. **RNA Polymerase II Regulation**: BICRAL is involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 3. **Cell Proliferation and Differentiation**: BICRAL promotes cell proliferation and inhibits cell differentiation, highlighting its role in maintaining stem cell populations and regulating cell fate decisions. 4. **GABAergic Cortical Interneurons**: BICRAL is specifically expressed in GABAergic cortical interneurons, a type of neuron involved in regulating neuronal activity and synaptic transmission. **Pathways and Functions:** 1. **Chromatin Remodeling**: BICRAL participates in chromatin remodeling, a process that involves the reorganization of chromatin structure to regulate gene expression. 2. **Transcriptional Regulation**: BICRAL regulates transcription by RNA polymerase II, influencing the expression of genes involved in cell proliferation, differentiation, and survival. 3. **Cell Proliferation and Maintenance**: BICRAL promotes cell proliferation and maintains stem cell populations, highlighting its role in regulating cell fate decisions and tissue development. 4. **GBAF Complex**: BICRAL is part of the GBAF (GBA fused to SWI/SNF) complex, a chromatin remodeling complex involved in regulating gene expression and cell proliferation. **Clinical Significance:** 1. **Neurological Disorders**: Dysregulation of BICRAL expression has been implicated in neurological disorders, such as epilepsy and schizophrenia, which are characterized by abnormal neuronal activity and synaptic transmission. 2. **Cancer**: BICRAL overexpression has been observed in certain types of cancer, suggesting its potential role in promoting cell proliferation and tumor progression. 3. **Cardiac Disease**: BICRAL expression has been linked to cardiac disease, including heart failure and arrhythmias, highlighting its potential role in regulating cardiac cell function and survival. 4. **Stem Cell Therapies**: Understanding the role of BICRAL in maintaining stem cell populations has implications for the development of stem cell-based therapies for regenerative medicine and tissue engineering. In conclusion, BICRAL is a critical regulator of chromatin remodeling, transcriptional regulation, and cell proliferation. Its dysregulation has been implicated in various diseases, including neurological disorders, cancer, and cardiac disease. Further research is needed to fully elucidate the functions of BICRAL and its potential therapeutic applications.

Genular Protein ID: 2999201953

Symbol: BICRL_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6AI39 A1L3W2 Q5TFZ3 Q92514

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 EMBL 7 EPD 1 Ensembl 2 GO 9 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29374058

Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

PubMed ID: 29374058

DOI: 10.1074/jbc.ra117.001065

Sequence Information:

  • Length: 1079
  • Mass: 115084
  • Checksum: 92357E9993343A76
  • Sequence:
    • MDDDDDSCLL DLIGDPQALN YFLHGPSNKS SNDDLTNAGY SAANSNSIFA NSSNADPKSS 
LKGVSNQLGE GPSDGLPLSS SLQFLEDELE SSPLPDLTED QPFDILQKSL QEANITEQTL 
AEEAYLDASI GSSQQFAQAQ LHPSSSASFT QASNVSNYSG QTLQPIGVTH VPVGASFASN 
TVGVQHGFMQ HVGISVPSQH LSNSSQISGS GQIQLIGSFG NHPSMMTINN LDGSQIILKG 
SGQQAPSNVS GGLLVHRQTP NGNSLFGNSS SSPVAQPVTV PFNSTNFQTS LPVHNIIIQR 
GLAPNSNKVP INIQPKPIQM GQQNTYNVNN LGIQQHHVQQ GISFASASSP QGSVVGPHMS 
VNIVNQQNTR KPVTSQAVSS TGGSIVIHSP MGQPHAPQSQ FLIPTSLSVS SNSVHHVQTI 
NGQLLQTQPS QLISGQVASE HVMLNRNSSN MLRTNQPYTG PMLNNQNTAV HLVSGQTFAA 
SGSPVIANHA SPQLVGGQMP LQQASPTVLH LSPGQSSVSQ GRPGFATMPS VTSMSGPSRF 
PAVSSASTAH PSLGSAVQSG SSGSNFTGDQ LTQPNRTPVP VSVSHRLPVS SSKSTSTFSN 
TPGTGTQQQF FCQAQKKCLN QTSPISAPKT TDGLRQAQIP GLLSTTLPGQ DSGSKVISAS 
LGTAQPQQEK VVGSSPGHPA VQVESHSGGQ KRPAAKQLTK GAFILQQLQR DQAHTVTPDK 
SHFRSLSDAV QRLLSYHVCQ GSMPTEEDLR KVDNEFETVA TQLLKRTQAM LNKYRCLLLE 
DAMRINPSAE MVMIDRMFNQ EERASLSRDK RLALVDPEGF QADFCCSFKL DKAAHETQFG 
RSDQHGSKAS SSLQPPAKAQ GRDRAKTGVT EPMNHDQFHL VPNHIVVSAE GNISKKTECL 
GRALKFDKVG LVQYQSTSEE KASRREPLKA SQCSPGPEGH RKTSSRSDHG TESKLSSILA 
DSHLEMTCNN SFQDKSLRNS PKNEVLHTDI MKGSGEPQPD LQLTKSLETT FKNILELKKA 
GRQPQSDPTV SGSVELDFPN FSPMASQENC LEKFIPDHSE GVVETDSILE AAVNSILEC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.