Details for: LRRC8B

Gene ID: 23507

Symbol: LRRC8B

Ensembl ID: ENSG00000197147

Description: leucine rich repeat containing 8 VRAC subunit B

Associated with

Other Information

Genular Protein ID: 798108121

Symbol: LRC8B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P9F7 D3DT28 Q6UY21 Q8N106 Q92627

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 12 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22532330

Title: LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.

PubMed ID: 22532330

DOI: 10.1002/bies.201100173

PubMed ID: 24790029

Title: Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

PubMed ID: 24790029

DOI: 10.1126/science.1252826

PubMed ID: 26824658

Title: LRRC8 proteins form volume-regulated anion channels that sense ionic strength.

PubMed ID: 26824658

DOI: 10.1016/j.cell.2015.12.031

PubMed ID: 28193731

Title: Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

PubMed ID: 28193731

DOI: 10.1242/jcs.196253

Sequence Information:

  • Length: 803
  • Mass: 92390
  • Checksum: 9006CE628F427EB9
  • Sequence:
    • MITLTELKCL ADAQSSYHIL KPWWDVFWYY ITLIMLLVAV LAGALQLTQS RVLCCLPCKV 
EFDNHCAVPW DILKASMNTS SNPGTPLPLP LRIQNDLHRQ QYSYIDAVCY EKQLHWFAKF 
FPYLVLLHTL IFAACSNFWL HYPSTSSRLE HFVAILHKCF DSPWTTRALS ETVAEQSVRP 
LKLSKSKILL SSSGCSADID SGKQSLPYPQ PGLESAGIES PTSSVLDKKE GEQAKAIFEK 
VKRFRMHVEQ KDIIYRVYLK QIIVKVILFV LIITYVPYFL THITLEIDCS VDVQAFTGYK 
RYQCVYSLAE IFKVLASFYV ILVILYGLTS SYSLWWMLRS SLKQYSFEAL REKSNYSDIP 
DVKNDFAFIL HLADQYDPLY SKRFSIFLSE VSENKLKQIN LNNEWTVEKL KSKLVKNAQD 
KIELHLFMLN GLPDNVFELT EMEVLSLELI PEVKLPSAVS QLVNLKELRV YHSSLVVDHP 
ALAFLEENLK ILRLKFTEMG KIPRWVFHLK NLKELYLSGC VLPEQLSTMQ LEGFQDLKNL 
RTLYLKSSLS RIPQVVTDLL PSLQKLSLDN EGSKLVVLNN LKKMVNLKSL ELISCDLERI 
PHSIFSLNNL HELDLRENNL KTVEEIISFQ HLQNLSCLKL WHNNIAYIPA QIGALSNLEQ 
LSLDHNNIEN LPLQLFLCTK LHYLDLSYNH LTFIPEEIQY LSNLQYFAVT NNNIEMLPDG 
LFQCKKLQCL LLGKNSLMNL SPHVGELSNL THLELIGNYL ETLPPELEGC QSLKRNCLIV 
EENLLNTLPL PVTERLQTCL DKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.