Details for: SUZ12
Associated with
Other Information
Genular Protein ID: 5941880
Symbol: SUZ12_HUMAN
Name: Polycomb protein SUZ12
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8590280
Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 8590280
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11371647
Title: Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.
PubMed ID: 11371647
PubMed ID: 11564866
Title: Use of chromatin immunoprecipitation to clone novel E2F target promoters.
PubMed ID: 11564866
PubMed ID: 12435631
Title: Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
PubMed ID: 12435631
DOI: 10.1101/gad.1035902
PubMed ID: 12351676
Title: Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
PubMed ID: 12351676
PubMed ID: 14532106
Title: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
PubMed ID: 14532106
DOI: 10.1093/emboj/cdg542
PubMed ID: 15385962
Title: Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
PubMed ID: 15385962
PubMed ID: 15231737
Title: Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
PubMed ID: 15231737
DOI: 10.1101/gad.1200204
PubMed ID: 15099518
Title: Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.
PubMed ID: 15099518
PubMed ID: 15225548
Title: SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
PubMed ID: 15225548
PubMed ID: 15684044
Title: Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
PubMed ID: 15684044
PubMed ID: 16224021
Title: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
PubMed ID: 16224021
PubMed ID: 16712789
Title: Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.
PubMed ID: 16712789
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16618801
Title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.
PubMed ID: 16618801
DOI: 10.1101/gad.381706
PubMed ID: 16431907
Title: Substrate preferences of the EZH2 histone methyltransferase complex.
PubMed ID: 16431907
PubMed ID: 17344414
Title: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
PubMed ID: 17344414
DOI: 10.1101/gad.415507
PubMed ID: 17200670
Title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
PubMed ID: 17200670
DOI: 10.1038/ng1950
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 19026781
Title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
PubMed ID: 19026781
PubMed ID: 18086877
Title: Role of hPHF1 in H3K27 methylation and Hox gene silencing.
PubMed ID: 18086877
DOI: 10.1128/mcb.01589-07
PubMed ID: 18285464
Title: Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
PubMed ID: 18285464
DOI: 10.1128/mcb.02017-07
PubMed ID: 18628979
Title: The polycomb repressive complex 2 is a potential target of SUMO modifications.
PubMed ID: 18628979
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18772439
Title: A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells.
PubMed ID: 18772439
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22009739
Title: Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.
PubMed ID: 22009739
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 28229514
Title: Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.
PubMed ID: 28229514
DOI: 10.1002/humu.23200
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30026490
Title: Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.
PubMed ID: 30026490
PubMed ID: 30923826
Title: EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.
PubMed ID: 30923826
PubMed ID: 29499137
Title: Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
PubMed ID: 29499137
PubMed ID: 31959557
Title: A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
PubMed ID: 31959557
PubMed ID: 30019515
PubMed ID: 31736240
Title: Rare SUZ12 variants commonly cause an overgrowth phenotype.
PubMed ID: 31736240
DOI: 10.1002/ajmg.c.31748
Sequence Information:
- Length: 739
- Mass: 83055
- Checksum: A8830EBC3FD38D56
- Sequence:
MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA VAAATASGGK SGGGSCGGGG SYSASSSSSA AAAAGAAVLP VKKPKMEHVQ ADHELFLQAF EKPTQIYRFL RTRNLIAPIF LHRTLTYMSH RNSRTNIKRK TFKVDDMLSK VEKMKGEQES HSLSAHLQLT FTGFFHKNDK PSPNSENEQN SVTLEVLLVK VCHKKRKDVS CPIRQVPTGK KQVPLNPDLN QTKPGNFPSL AVSSNEFEPS NSHMVKSYSL LFRVTRPGRR EFNGMINGET NENIDVNEEL PARRKRNRED GEKTFVAQMT VFDKNRRLQL LDGEYEVAMQ EMEECPISKK RATWETILDG KRLPPFETFS QGPTLQFTLR WTGETNDKST APIAKPLATR NSESLHQENK PGSVKPTQTI AVKESLTTDL QTRKEKDTPN ENRQKLRIFY QFLYNNNTRQ QTEARDDLHC PWCTLNCRKL YSLLKHLKLC HSRFIFNYVY HPKGARIDVS INECYDGSYA GNPQDIHRQP GFAFSRNGPV KRTPITHILV CRPKRTKASM SEFLESEDGE VEQQRTYSSG HNRLYFHSDT CLPLRPQEME VDSEDEKDPE WLREKTITQI EEFSDVNEGE KEVMKLWNLH VMKHGFIADN QMNHACMLFV ENYGQKIIKK NLCRNFMLHL VSMHDFNLIS IMSIDKAVTK LREMQQKLEK GESASPANEE ITEEQNGTAN GFSEINSKEK ALETDSVSGV SKQSKKQKL
Genular Protein ID: 2971262872
Symbol: J3QQW9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 716
- Mass: 80322
- Checksum: 7DC4178E12AEB8D7
- Sequence:
MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA VAAATASGGK SGGGSCGGGG SYSASSSSSA AAAAGAAVLP VKKPKMEHVQ ADHELFLQAF EKPTQIYRFL RTRNLIAPIF LHRTLTYMSH RNSRTNIKSL SAHLQLTFTG FFHKNDKPSP NSENEQNSVT LEVLLVKVCH KKRKDVSCPI RQVPTGKKQV PLNPDLNQTK PGNFPSLAVS SNEFEPSNSH MVKSYSLLFR VTRPGRREFN GMINGETNEN IDVNEELPAR RKRNREDGEK TFVAQMTVFD KNRRLQLLDG EYEVAMQEME ECPISKKRAT WETILDGKRL PPFETFSQGP TLQFTLRWTG ETNDKSTAPI AKPLATRNSE SLHQENKPGS VKPTQTIAVK ESLTTDLQTR KEKDTPNENR QKLRIFYQFL YNNNTRQQTE ARDDLHCPWC TLNCRKLYSL LKHLKLCHSR FIFNYVYHPK GARIDVSINE CYDGSYAGNP QDIHRQPGFA FSRNGPVKRT PITHILVCRP KRTKASMSEF LESEDGEVEQ QRTYSSGHNR LYFHSDTCLP LRPQEMEVDS EDEKDPEWLR EKTITQIEEF SDVNEGEKEV MKLWNLHVMK HGFIADNQMN HACMLFVENY GQKIIKKNLC RNFMLHLVSM HDFNLISIMS IDKAVTKLRE MQQKLEKGES ASPANEEITE EQNGTANGFS EINSKEKALE TDSVSGVSKQ SKKQKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.