Details for: MTREX
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 4.41
Marker Score: 58,614 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.72
Marker Score: 1,321 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.13
Marker Score: 4,675 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.86
Marker Score: 27,794 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.86
Marker Score: 36,926 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.82
Marker Score: 69,088 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.77
Marker Score: 13,537 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.73
Marker Score: 2,154 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.73
Marker Score: 36,817 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.72
Marker Score: 6,667 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.71
Marker Score: 1,885 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.7
Marker Score: 62,798 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.7
Marker Score: 992 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.69
Marker Score: 103,975 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.68
Marker Score: 15,999 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.68
Marker Score: 1,928 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.66
Marker Score: 15,639 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.66
Marker Score: 6,873 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.63
Marker Score: 14,004 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.63
Marker Score: 3,901 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.62
Marker Score: 6,770 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.6
Marker Score: 2,149 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.58
Marker Score: 1,449 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.54
Marker Score: 451 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.53
Marker Score: 15,754 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.52
Marker Score: 2,931 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.52
Marker Score: 795 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.52
Marker Score: 1,838 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.45
Marker Score: 2,237 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.43
Marker Score: 5,075 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.42
Marker Score: 410 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.4
Marker Score: 31,199 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.39
Marker Score: 830 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.37
Marker Score: 1,968 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.36
Marker Score: 1,216 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.36
Marker Score: 912 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.36
Marker Score: 570 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.29
Marker Score: 409 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.29
Marker Score: 1,614 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.28
Marker Score: 1,384 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.28
Marker Score: 1,599 - Cell Name: fat cell (CL0000136)
Fold Change: 1.26
Marker Score: 704 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.26
Marker Score: 852 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.24
Marker Score: 393 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.19
Marker Score: 628 - Cell Name: neuron (CL0000540)
Fold Change: 1.19
Marker Score: 4,835 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.17
Marker Score: 1,120 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.17
Marker Score: 321 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.14
Marker Score: 1,414 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.14
Marker Score: 329 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.12
Marker Score: 625 - Cell Name: Schwann cell (CL0002573)
Fold Change: 1.11
Marker Score: 386 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.11
Marker Score: 2,609 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.09
Marker Score: 757 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.09
Marker Score: 923 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.08
Marker Score: 1,136 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.08
Marker Score: 1,092 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.06
Marker Score: 1,556 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.04
Marker Score: 1,103 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.04
Marker Score: 518 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.03
Marker Score: 704 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.03
Marker Score: 575 - Cell Name: osteoclast (CL0000092)
Fold Change: 1.03
Marker Score: 511 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.02
Marker Score: 15,938 - Cell Name: neural cell (CL0002319)
Fold Change: 1.02
Marker Score: 490 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.01
Marker Score: 381 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.01
Marker Score: 776 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.01
Marker Score: 669 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1
Marker Score: 1,011 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1
Marker Score: 202 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,613 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,840 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Marker Score: 2,065 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.99
Marker Score: 400 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.99
Marker Score: 2,814 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,379 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.98
Marker Score: 4,512 - Cell Name: podocyte (CL0000653)
Fold Change: 0.97
Marker Score: 360 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.96
Marker Score: 530 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.96
Marker Score: 272 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.95
Marker Score: 3,517 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.95
Marker Score: 553 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.95
Marker Score: 634 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.95
Marker Score: 1,340 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.95
Marker Score: 226 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.94
Marker Score: 320 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,385 - Cell Name: enteric neuron (CL0007011)
Fold Change: 0.94
Marker Score: 499 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.94
Marker Score: 625 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.94
Marker Score: 281 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.93
Marker Score: 8,110 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.93
Marker Score: 1,586 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.93
Marker Score: 230 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.93
Marker Score: 826 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.93
Marker Score: 1,002 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.93
Marker Score: 991 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.93
Marker Score: 2,334 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 476 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 433 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.91
Marker Score: 214
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1160870178
Symbol: MTREX_HUMAN
Name: ATP-dependent RNA helicase SKIV2L2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7584044
Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7584044
PubMed ID: 16782053
Title: The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.
PubMed ID: 16782053
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11719186
Title: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
PubMed ID: 11719186
PubMed ID: 12429849
Title: Functional proteomic analysis of human nucleolus.
PubMed ID: 12429849
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 16263084
Title: Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins.
PubMed ID: 16263084
PubMed ID: 17412707
Title: C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.
PubMed ID: 17412707
DOI: 10.1093/nar/gkm082
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21855801
Title: Interaction profiling identifies the human nuclear exosome targeting complex.
PubMed ID: 21855801
PubMed ID: 22817747
Title: Comparison of the yeast and human nuclear exosome complexes.
PubMed ID: 22817747
DOI: 10.1042/bst20120061
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26166824
Title: NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.
PubMed ID: 26166824
PubMed ID: 26456651
Title: AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.
PubMed ID: 26456651
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 27871484
Title: Identification of a nuclear exosome decay pathway for processed transcripts.
PubMed ID: 27871484
PubMed ID: 27905398
Title: Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.
PubMed ID: 27905398
DOI: 10.1038/ncomms13573
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29107693
Title: WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2.
PubMed ID: 29107693
PubMed ID: 29902117
Title: NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells.
PubMed ID: 29902117
PubMed ID: 30538148
Title: Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.
PubMed ID: 30538148
PubMed ID: 29906447
Title: Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
PubMed ID: 29906447
PubMed ID: 29844170
Title: Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.
PubMed ID: 29844170
PubMed ID: 30842217
Title: NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
PubMed ID: 30842217
PubMed ID: 31358741
Title: The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
PubMed ID: 31358741
Sequence Information:
- Length: 1042
- Mass: 117805
- Checksum: 49F47BEC753FBEE7
- Sequence:
MADAFGDELF SVFEGDSTTA AGTKKDKEKD KGKWKGPPGS ADKAGKRFDG KLQSESTNNG KNKRDVDFEG TDEPIFGKKP RIEESITEDL SLADLMPRVK VQSVETVEGC THEVALPAEE DYLPLKPRVG KAAKEYPFIL DAFQREAIQC VDNNQSVLVS AHTSAGKTVC AEYAIALALR EKQRVIFTSP IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS EVMREVAWVI FDEIHYMRDS ERGVVWEETI ILLPDNVHYV FLSATIPNAR QFAEWICHLH KQPCHVIYTD YRPTPLQHYI FPAGGDGLHL VVDENGDFRE DNFNTAMQVL RDAGDLAKGD QKGRKGGTKG PSNVFKIVKM IMERNFQPVI IFSFSKKDCE AYALQMTKLD FNTDEEKKMV EEVFSNAIDC LSDEDKKLPQ VEHVLPLLKR GIGIHHGGLL PILKETIEIL FSEGLIKALF ATETFAMGIN MPARTVLFTN ARKFDGKDFR WISSGEYIQM SGRAGRRGMD DRGIVILMVD EKMSPTIGKQ LLKGSADPLN SAFHLTYNMV LNLLRVEEIN PEYMLEKSFY QFQHYRAIPG VVEKVKNSEE QYNKIVIPNE ESVVIYYKIR QQLAKLGKEI EEYIHKPKYC LPFLQPGRLV KVKNEGDDFG WGVVVNFSKK SNVKPNSGEL DPLYVVEVLL RCSKESLKNS ATEAAKPAKP DEKGEMQVVP VLVHLLSAIS SVRLYIPKDL RPVDNRQSVL KSIQEVQKRF PDGIPLLDPI DDMGIQDQGL KKVIQKVEAF EHRMYSHPLH NDPNLETVYT LCEKKAQIAI DIKSAKRELK KARTVLQMDE LKCRKRVLRR LGFATSSDVI EMKGRVACEI SSADELLLTE MMFNGLFNDL SAEQATALLS CFVFQENSSE MPKLTEQLAG PLRQMQECAK RIAKVSAEAK LEIDEETYLS SFKPHLMDVV YTWATGATFA HICKMTDVFE GSIIRCMRRL EELLRQMCQA AKAIGNTELE NKFAEGITKI KRDIVFAASL YL
Genular Protein ID: 2387307956
Symbol: Q3MHC9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 67
- Mass: 7336
- Checksum: 9A4E0689BFCACC89
- Sequence:
MADAFGDELF SVFEGDSTTA AGTKKDKEKD KGKWKGPPGS ADKAGKRFDG KLQSESTKKK KKKKKKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.