Details for: KAT6B

Gene ID: 23522

Symbol: KAT6B

Ensembl ID: ENSG00000156650

Description: lysine acetyltransferase 6B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.94
    Marker Score: 3,151
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.78
    Marker Score: 19,840
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.32
    Marker Score: 112,071
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.32
    Marker Score: 74,122
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.15
    Marker Score: 10,570
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.86
    Marker Score: 21,577
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.83
    Marker Score: 1,574
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.57
    Marker Score: 2,221
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.54
    Marker Score: 13,621
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.51
    Marker Score: 1,407
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.48
    Marker Score: 1,870
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.45
    Marker Score: 18,775
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.41
    Marker Score: 4,636
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.37
    Marker Score: 50,504
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.35
    Marker Score: 35,146
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.35
    Marker Score: 41,636
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.31
    Marker Score: 5,303
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.3
    Marker Score: 45,764
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.27
    Marker Score: 86,375
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.25
    Marker Score: 10,410
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82,666
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.22
    Marker Score: 1,291
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.22
    Marker Score: 9,212
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.21
    Marker Score: 4,860
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.19
    Marker Score: 5,488
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.17
    Marker Score: 1,262
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.16
    Marker Score: 8,995
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.11
    Marker Score: 2,544
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1
    Marker Score: 8,131
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.09
    Marker Score: 1,004
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.04
    Marker Score: 2,544
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.01
    Marker Score: 1,918
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2
    Marker Score: 635
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121,861
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.98
    Marker Score: 1,022
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.97
    Marker Score: 1,152
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.97
    Marker Score: 5,617
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.93
    Marker Score: 1,484
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.91
    Marker Score: 1,350
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.91
    Marker Score: 630
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.9
    Marker Score: 1,060
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17,788
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.88
    Marker Score: 2,641
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.87
    Marker Score: 2,155
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.86
    Marker Score: 2,058
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.86
    Marker Score: 17,682
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.81
    Marker Score: 2,194
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.81
    Marker Score: 6,434
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15,499
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8
    Marker Score: 18,586
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.79
    Marker Score: 774
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.77
    Marker Score: 7,412
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.77
    Marker Score: 2,003
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.74
    Marker Score: 7,092
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.7
    Marker Score: 4,081
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.68
    Marker Score: 2,822
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.66
    Marker Score: 2,238
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.65
    Marker Score: 868
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.64
    Marker Score: 688
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1,422
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.64
    Marker Score: 479
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.63
    Marker Score: 1,756
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.61
    Marker Score: 464
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.58
    Marker Score: 3,595
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.56
    Marker Score: 773
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,385
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.54
    Marker Score: 835
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.54
    Marker Score: 1,049
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.54
    Marker Score: 1,618
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.51
    Marker Score: 1,868
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.49
    Marker Score: 1,038
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.49
    Marker Score: 724
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.49
    Marker Score: 753
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.49
    Marker Score: 658
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.49
    Marker Score: 15,055
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.47
    Marker Score: 566
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.46
    Marker Score: 14,710
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.45
    Marker Score: 450
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.44
    Marker Score: 2,036
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.43
    Marker Score: 1,271
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.43
    Marker Score: 390
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.42
    Marker Score: 22,806
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.38
    Marker Score: 831
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.38
    Marker Score: 357
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.37
    Marker Score: 348
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.36
    Marker Score: 678
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.36
    Marker Score: 501
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.35
    Marker Score: 1,020
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.34
    Marker Score: 501
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.34
    Marker Score: 421
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.34
    Marker Score: 501
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.33
    Marker Score: 1,409
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.32
    Marker Score: 1,401
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.32
    Marker Score: 7,827
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.32
    Marker Score: 315
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.3
    Marker Score: 420
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.3
    Marker Score: 299
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.29
    Marker Score: 473
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.29
    Marker Score: 524
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.29
    Marker Score: 14,565

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KAT6B is a histone acetyltransferase (HAT) enzyme that acetylates lysine residues on histone proteins, leading to chromatin relaxation and enhanced transcriptional activity. This gene is specifically expressed in various cell types, including pulmonary interstitial fibroblasts, neurons, and cardiac myocytes. KAT6B is also involved in the regulation of developmental processes, such as hemopoiesis and transcriptional regulation by RNA polymerase II. **Pathways and Functions:** KAT6B is involved in several key pathways, including: 1. **Chromatin binding and modification:** KAT6B binds to chromatin and acetylates histones, leading to chromatin relaxation and enhanced transcriptional activity. 2. **Histone acetylation:** KAT6B acetylates lysine residues on histones, leading to increased chromatin accessibility and transcriptional activation. 3. **Regulation of developmental processes:** KAT6B is involved in the regulation of hemopoiesis, transcriptional regulation by RNA polymerase II, and regulation of DNA-templated transcription. 4. **Transcription coactivation and coregulation:** KAT6B acts as a transcription coactivator and coregulator, enhancing the activity of transcription factors and regulating gene expression. **Clinical Significance:** Dysregulation of KAT6B has been implicated in various diseases, including: 1. **Neurological disorders:** Mutations in KAT6B have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** KAT6B is overexpressed in certain types of cancer, including leukemia and lymphoma, and has been implicated in tumorigenesis and cancer progression. 3. **Cardiac disease:** KAT6B has been shown to play a role in cardiac development and function, and its dysregulation has been implicated in cardiac disease, including heart failure and arrhythmias. In conclusion, KAT6B is a critical gene involved in chromatin regulation, developmental processes, and transcriptional activity. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of KAT6B and its role in human disease. **Recommendations:** 1. Further research is needed to understand the mechanisms of KAT6B and its role in human disease. 2. KAT6B may serve as a potential therapeutic target for the treatment of neurological disorders, cancer, and cardiac disease. 3. The study of KAT6B's role in chromatin regulation and transcriptional activity may provide insights into the development of new therapeutic strategies for various diseases. **Future Directions:** The study of KAT6B and its role in chromatin regulation, developmental processes, and transcriptional activity has significant implications for our understanding of human disease. Further research is needed to elucidate the mechanisms of KAT6B and its potential therapeutic applications.

Genular Protein ID: 1174466883

Symbol: KAT6B_HUMAN

Name: Histone acetyltransferase KAT6B

UniProtKB Accession Codes:

Q8WYB5 O15087 Q86Y05 Q8WU81 Q9UKW2 Q9UKW3 Q9UKX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 18 ExpressionAtlas 1 GO 19 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 12 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10497217

Title: Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein.

PubMed ID: 10497217

DOI: 10.1074/jbc.274.40.28528

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11157802

Title: Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).

PubMed ID: 11157802

DOI: 10.1093/hmg/10.4.395

PubMed ID: 11965546

Title: MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.

PubMed ID: 11965546

DOI: 10.1038/sj.onc.1205367

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 18794358

Title: Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

PubMed ID: 18794358

DOI: 10.1128/mcb.01297-08

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 22077973

Title: Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome.

PubMed ID: 22077973

DOI: 10.1016/j.ajhg.2011.10.008

PubMed ID: 22265014

Title: Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome.

PubMed ID: 22265014

DOI: 10.1016/j.ajhg.2011.11.023

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 2073
  • Mass: 231378
  • Checksum: AEE267B9DA444B08
  • Sequence:
    • MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ LELSVQDGSV 
LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN DLRNVDWNKL LRRAIEGLEE 
PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD 
GKGAPQYPSA FPSSLPPVSL LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC 
GSSGHPSCLK FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC 
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK QRLLSVTSDE 
GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA VTDPTRPGAT TKITTTSTYI 
SASTLKVNKK TKGLIDGLTK FFTPSPDGRR SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA 
TGTTQKLKPP PSSLPPPTPI SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL 
KALFDGLSHI YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH 
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK GSLTDGRIKP 
DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ ELSWEKIECE SGVEDCGRYP 
SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL CEFCLKYMKS KNILLRHSKK CGWFHPPANE 
IYRRKDLSVF EVDGNMSKIY CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV 
GYFSKEKLCQ QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL 
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK RDGRFVIIRR 
EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE EREAEKEAER LMEQASCWEK 
EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE SRPVTGERGQ LLELSKESSE EEEEEEDEEE 
EEEEEEEEED EEEEEEEEEE EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI 
NSSVTTETIS ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK 
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK GTKRGLSKWR 
QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT SPSPIRIEEE VKETGEALLP 
QEENRREETC APVSPNTSPG EKPEDDLIKP EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK 
DPDGAKSQEK EEPEISTEKE DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE 
KEELPRESFK EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP 
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ ESSEQDDTFQ 
DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV SSVHSHPGQS VRSVNSPSVP 
ALENSYAQIS PDQSAISVPS LQNMETSPMM DVPSVSDHSQ QVVDSGFSDL GSIESTTENY 
ENPSSYDSTM GGSICGNGSS QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI 
SSPPTCSVKS PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ 
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS TPLSNTGLVQ 
LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM AASNIGISHS QRLQTQIASK 
GHISMRTKSA SLSPAAATHQ SQIYGRSQTV AMQGPARTLT MQRGMNMSVN LMPAPAYNVN 
SVNMNMNTLN AMNGYSMSQP MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT 
PPHGNMMYTA PGHHGYMNTG MSKQSLNGSY MRR

Genular Protein ID: 2383146021

Symbol: B2RWN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RWN8

Database IDs:

ARBA 13 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 7 Gene3D 4 GenomeRNAi 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 3 Rhea 3 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 2073
  • Mass: 231390
  • Checksum: 1BBC7262B7F3D81D
  • Sequence:
    • MVKLANPLYI EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ LELSVQDGSV 
LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN DLRNVDWNKL LRRAIEGLEE 
PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD 
GKGAPQYPSA FPSSLPPVSL LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC 
GSSGHPSCLK FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC 
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK QRLLSVTSDE 
GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA VTDPTRPGAT TKITTTSTYI 
SASTLKVNKK TKGLIDGLTK FFTPSPDGRR SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA 
TGTTQKLKPP PSSLPPPTPI SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL 
KALFDGLSHI YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH 
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK GSLTDGRIKP 
DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ ELSWEKIECE SGVEDCGRYP 
SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL CEFCLKYMKS KNILLRHSKK CGWFHPPANE 
IYRRKDLSVF EVDGNMSKIY CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV 
GYFSKEKLCQ QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL 
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK RDGRFVIIRR 
EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE EREAEKEAER LMEQASCWEK 
EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE SRPVTGERGQ LLELSKESSE EEEEEEDEEE 
EEEEEEEEED EEEEEEEEEE EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI 
NSSVTTETIS ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK 
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK GTKRGLSKWR 
QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT SPSPIRIEEE VKETGEALLP 
QEENRREETC APVSPNTSPG EKPEDDLIKP EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK 
DPDGAKSQEK EEPEISTEKE DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE 
KEELPRESFK EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP 
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ ESSEQDDTFQ 
DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV SSVHSHPGQS VRSVNSPSVP 
ALENSYAQIS PDQSAISVPS LQNMETSPMM DVPSVSDHSQ QVVDSGFSDL GSIESTTENY 
ENPSSYDSTM GGSICGNGSS QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI 
SSPPTCSVKS PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ 
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS TPLSNTGLVQ 
LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM AASNIGISHS QRLQTQIASK 
GHISMRTKSA SLSPAAATHQ SQIYGRSQTV AMQGPARTLT MQRGMNMSVN LMPAPAYNVN 
SVNMNMNTLN AMNGYSMSQP MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT 
PPHGNMMYTA PGHHGYMNTG MSKQSLNGSY MRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.