Details for: SRRM2

Gene ID: 23524

Symbol: SRRM2

Ensembl ID: ENSG00000167978

Description: serine/arginine repetitive matrix 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.88
    Marker Score: 132,126
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.44
    Marker Score: 3,392
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.39
    Marker Score: 3,622
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.33
    Marker Score: 3,778
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.32
    Marker Score: 2,827
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.18
    Marker Score: 13,254
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.16
    Marker Score: 2,112
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.09
    Marker Score: 8,665
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.06
    Marker Score: 15,045
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.04
    Marker Score: 105,243
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.02
    Marker Score: 2,881
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.95
    Marker Score: 7,213
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.93
    Marker Score: 699
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.88
    Marker Score: 5,550
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.88
    Marker Score: 1,243
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.86
    Marker Score: 1,725
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.86
    Marker Score: 1,588
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.84
    Marker Score: 1,052
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.79
    Marker Score: 2,615
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.79
    Marker Score: 988
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.79
    Marker Score: 1,354
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.78
    Marker Score: 1,135
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.77
    Marker Score: 6,086
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.77
    Marker Score: 28,051
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.71
    Marker Score: 2,281
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.71
    Marker Score: 1,128
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.71
    Marker Score: 30,470
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.7
    Marker Score: 2,048
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.7
    Marker Score: 1,515
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.7
    Marker Score: 2,913
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.69
    Marker Score: 937
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.66
    Marker Score: 928
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.65
    Marker Score: 764
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.64
    Marker Score: 1,305
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.64
    Marker Score: 147,676
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.64
    Marker Score: 17,154
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.63
    Marker Score: 2,771
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.63
    Marker Score: 5,508
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.62
    Marker Score: 1,493
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6
    Marker Score: 41,802
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6
    Marker Score: 3,144
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.6
    Marker Score: 1,625
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.6
    Marker Score: 2,039
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.59
    Marker Score: 1,051
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.57
    Marker Score: 4,829
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.55
    Marker Score: 8,778
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.55
    Marker Score: 2,407
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.53
    Marker Score: 10,604
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.53
    Marker Score: 1,259
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.51
    Marker Score: 948
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.51
    Marker Score: 2,732
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 2.51
    Marker Score: 738
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.49
    Marker Score: 821
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.49
    Marker Score: 14,787
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.48
    Marker Score: 3,204
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.47
    Marker Score: 1,950
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.47
    Marker Score: 566
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.47
    Marker Score: 1,232
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.46
    Marker Score: 1,680
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.46
    Marker Score: 2,132
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.46
    Marker Score: 12,911
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.45
    Marker Score: 1,212
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.45
    Marker Score: 18,254
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.45
    Marker Score: 1,729
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.45
    Marker Score: 6,554
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.44
    Marker Score: 1,419
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.43
    Marker Score: 3,585
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 2.43
    Marker Score: 844
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.43
    Marker Score: 2,797
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.43
    Marker Score: 752
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.42
    Marker Score: 597
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.41
    Marker Score: 1,384
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.41
    Marker Score: 688
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.41
    Marker Score: 15,693
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.41
    Marker Score: 1,821
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.4
    Marker Score: 2,208
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.4
    Marker Score: 1,597
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 2.4
    Marker Score: 1,111
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.39
    Marker Score: 5,454
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.39
    Marker Score: 4,234
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.39
    Marker Score: 3,212
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.38
    Marker Score: 685
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.37
    Marker Score: 518
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.37
    Marker Score: 31,203
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.36
    Marker Score: 848
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.35
    Marker Score: 23,611
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.35
    Marker Score: 877
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.34
    Marker Score: 2,100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.34
    Marker Score: 581
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.34
    Marker Score: 8,315
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 2.34
    Marker Score: 1,507
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 2.34
    Marker Score: 582
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.34
    Marker Score: 508
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.33
    Marker Score: 749
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.33
    Marker Score: 736
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 2.33
    Marker Score: 657
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.32
    Marker Score: 843
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.32
    Marker Score: 1,083
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.31
    Marker Score: 4,703
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.31
    Marker Score: 969

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Splicing:** SRRM2 is a key component of the U2-type spliceosome, a complex responsible for the regulation of alternative splicing of pre-mRNA. This process involves the recognition and removal of introns, resulting in the production of mature mRNA. 2. **Cajal Body:** SRRM2 is also associated with Cajal bodies, small nuclear structures involved in the regulation of RNA processing and the production of small RNAs. 3. **Zinc Finger Domain:** The C2h2 zinc finger domain of SRRM2 is crucial for its interaction with other proteins and the recognition of specific sequences, thereby modulating RNA splicing and other cellular processes. 4. **Multiple Protein Interactions:** SRRM2 interacts with various proteins, including other RNA-binding proteins, histone modifiers, and transcription factors, further highlighting its complex regulatory role. **Pathways and Functions:** 1. **Metabolism of RNA:** SRRM2 is involved in the regulation of RNA metabolism, including the processing of pre-mRNA and the production of small RNAs. 2. **Catalytic Step 2 Spliceosome:** SRRM2 is a key component of the U2-type spliceosome, which catalyzes the second step of RNA splicing. 3. **Mrna Splicing:** SRRM2 is essential for the regulation of mRNA splicing, influencing the production of mature mRNA and the resulting protein products. 4. **Cajal Body Formation:** SRRM2 is involved in the formation of Cajal bodies, which are crucial for the regulation of RNA processing and the production of small RNAs. 5. **Nuclear Speck Formation:** SRRM2 is also associated with nuclear specks, small nuclear structures involved in the regulation of RNA processing and the production of small RNAs. **Clinical Significance:** 1. **Cancer:** Dysregulation of SRRM2 has been implicated in various cancers, including breast cancer, lung cancer, and leukemia, highlighting its potential as a therapeutic target. 2. **Neurological Disorders:** SRRM2 has been associated with neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), suggesting its role in the regulation of RNA processing and the production of small RNAs. 3. **Immune Cell Regulation:** SRRM2 is expressed in immune cells, including T cells and B cells, and its dysregulation may contribute to immune-related disorders, such as autoimmune diseases and immunodeficiency syndromes. 4. **Muscle Cell Differentiation:** SRRM2 is involved in the regulation of muscle cell differentiation, highlighting its potential as a therapeutic target for muscle-related disorders, such as muscular dystrophy. In conclusion, SRRM2 is a complex gene that plays a critical role in RNA splicing, Cajal body formation, and nuclear speck formation, influencing various cellular processes and potentially contributing to the development of various diseases. Further research is necessary to fully elucidate the functional significance of SRRM2 and its potential as a therapeutic target.

Genular Protein ID: 2031896289

Symbol: SRRM2_HUMAN

Name: Serine/arginine repetitive matrix protein 2

UniProtKB Accession Codes:

Q9UQ35 A6NKB9 D3DU97 O15038 O94803 Q6NSL3 Q6PIM3 Q6PK40 Q8IW17 Q96GY7 Q9P0G1 Q9UHA8 Q9UQ36 Q9UQ37 Q9UQ38 Q9UQ40

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 EMDB 16 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 18 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11004489

Title: Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains.

PubMed ID: 11004489

DOI: 10.1016/s0167-4781(00)00065-8

PubMed ID: 10668804

Title: The SRm160/300 splicing coactivator subunits.

PubMed ID: 10668804

DOI: 10.1017/s1355838200991982

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9531537

Title: A coactivator of pre-mRNA splicing.

PubMed ID: 9531537

DOI: 10.1101/gad.12.7.996

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19854871

Title: Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.

PubMed ID: 19854871

DOI: 10.1261/rna.1908309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28062851

Title: Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.

PubMed ID: 28062851

DOI: 10.1242/jcs.194068

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 29361316

Title: Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

PubMed ID: 29361316

DOI: 10.1016/j.cell.2018.01.010

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 29301961

Title: Structure of a human catalytic step I spliceosome.

PubMed ID: 29301961

DOI: 10.1126/science.aar6401

PubMed ID: 30705154

Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

PubMed ID: 30705154

DOI: 10.1126/science.aaw5569

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 2752
  • Mass: 299615
  • Checksum: 7A5DCEB9B50AA912
  • Sequence:
    • MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRRLEAALV KRPNPDILDH 
ERKRRVELRC LELEEMMEEQ GYEEQQIQEK VATFRLMLLE KDVNPGGKEE TPGQRPAVTE 
THQLAELNEK KNERLRAAFG ISDSYVDGSS FDPQRRAREA KQPAPEPPKP YSLVRESSSS 
RSPTPKQKKK KKKKDRGRRS ESSSPRRERK KSSKKKKHRS ESESKKRKHR SPTPKSKRKS 
KDKKRKRSRS TTPAPKSRRA HRSTSADSAS SSDTSRSRSR SAAAKTHTTA LAGRSPSPAS 
GRRGEGDAPF SEPGTTSTQR PSSPETATKQ PSSPYEDKDK DKKEKSATRP SPSPERSSTG 
PEPPAPTPLL AERHGGSPQP LATTPLSQEP VNPPSEASPT RDRSPPKSPE KLPQSSSSES 
SPPSPQPTKV SRHASSSPES PKPAPAPGSH REISSSPTSK NRSHGRAKRD KSHSHTPSRR 
MGRSRSPATA KRGRSRSRTP TKRGHSRSRS PQWRRSRSAQ RWGRSRSPQR RGRSRSPQRP 
GWSRSRNTQR RGRSRSARRG RSHSRSPATR GRSRSRTPAR RGRSRSRTPA RRRSRSRTPT 
RRRSRSRTPA RRGRSRSRTP ARRRSRTRSP VRRRSRSRSP ARRSGRSRSR TPARRGRSRS 
RTPARRGRSR SRTPARRSGR SRSRTPARRG RSRSRTPRRG RSRSRSLVRR GRSHSRTPQR 
RGRSGSSSER KNKSRTSQRR SRSNSSPEMK KSRISSRRSR SLSSPRSKAK SRLSLRRSLS 
GSSPCPKQKS QTPPRRSRSG SSQPKAKSRT PPRRSRSSSS PPPKQKSKTP SRQSHSSSSP 
HPKVKSGTPP RQGSITSPQA NEQSVTPQRR SCFESSPDPE LKSRTPSRHS CSGSSPPRVK 
SSTPPRQSPS RSSSPQPKVK AIISPRQRSH SGSSSPSPSR VTSRTTPRRS RSVSPCSNVE 
SRLLPRYSHS GSSSPDTKVK PETPPRQSHS GSISPYPKVK AQTPPGPSLS GSKSPCPQEK 
SKDSLVQSCP GSLSLCAGVK SSTPPGESYF GVSSLQLKGQ SQTSPDHRSD TSSPEVRQSH 
SESPSLQSKS QTSPKGGRSR SSSPVTELAS RSPIRQDRGE FSASPMLKSG MSPEQSRFQS 
DSSSYPTVDS NSLLGQSRLE TAESKEKMAL PPQEDATASP PRQKDKFSPF PVQDRPESSL 
VFKDTLRTPP RERSGAGSSP ETKEQNSALP TSSQDEELME VVEKSEEPAG QILSHLSSEL 
KEMSTSNFES SPEVEERPAV SLTLDQSQSQ ASLEAVEVPS MASSWGGPHF SPEHKELSNS 
PLRENSFGSP LEFRNSGPLG TEMNTGFSSE VKEDLNGPFL NQLETDPSLD MKEQSTRSSG 
HSSSELSPDA VEKAGMSSNQ SISSPVLDAV PRTPSRERSS SASSPEMKDG LPRTPSRRSR 
SGSSPGLRDG SGTPSRHSLS GSSPGMKDIP RTPSRGRSEC DSSPEPKALP QTPRPRSRSP 
SSPELNNKCL TPQRERSGSE SSVDQKTVAR TPLGQRSRSG SSQELDVKPS ASPQERSESD 
SSPDSKAKTR TPLRQRSRSG SSPEVDSKSR LSPRRSRSGS SPEVKDKPRA APRAQSGSDS 
SPEPKAPAPR ALPRRSRSGS SSKGRGPSPE GSSSTESSPE HPPKSRTARR GSRSSPEPKT 
KSRTPPRRRS SRSSPELTRK ARLSRRSRSA SSSPETRSRT PPRHRRSPSV SSPEPAEKSR 
SSRRRRSASS PRTKTTSRRG RSPSPKPRGL QRSRSRSRRE KTRTTRRRDR SGSSQSTSRR 
RQRSRSRSRV TRRRRGGSGY HSRSPARQES SRTSSRRRRG RSRTPPTSRK RSRSRTSPAP 
WKRSRSRASP ATHRRSRSRT PLISRRRSRS RTSPVSRRRS RSRTSVTRRR SRSRASPVSR 
RRSRSRTPPV TRRRSRSRTP TTRRRSRSRT PPVTRRRSRS RTPPVTRRRS RSRTSPITRR 
RSRSRTSPVT RRRSRSRTSP VTRRRSRSRT SPVTRRRSRS RTPPAIRRRS RSRTPLLPRK 
RSRSRSPLAI RRRSRSRTPR TARGKRSLTR SPPAIRRRSA SGSSSDRSRS ATPPATRNHS 
GSRTPPVALN SSRMSCFSRP SMSPTPLDRC RSPGMLEPLG SSRTPMSVLQ QAGGSMMDGP 
GPRIPDHQRT SVPENHAQSR IALALTAISL GTARPPPSMS AAGLAARMSQ VPAPVPLMSL 
RTAPAANLAS RIPAASAAAM NLASARTPAI PTAVNLADSR TPAAAAAMNL ASPRTAVAPS 
AVNLADPRTP TAPAVNLAGA RTPAALAALS LTGSGTPPTA ANYPSSSRTP QAPASANLVG 
PRSAHATAPV NIAGSRTAAA LAPASLTSAR MAPALSGANL TSPRVPLSAY ERVSGRTSPP 
LLDRARSRTP PSAPSQSRMT SERAPSPSSR MGQAPSQSLL PPAQDQPRSP VPSAFSDQSR 
CLIAQTTPVA GSQSLSSGAV ATTTSSAGDH NGMLSVPAPG VPHSDVGEPP ASTGAQQPSA 
LAALQPAKER RSSSSSSSSS SSSSSSSSSS SSSSSSGSSS SDSEGSSLPV QPEVALKRVP 
SPTPAPKEAV REGRPPEPTP AKRKRRSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS 
SSSSSSSSPS PAKPGPQALP KPASPKKPPP GERRSRSPRK PIDSLRDSRS LSYSPVERRR 
PSPQPSPRDQ QSSSSERGSR RGQRGDSRSP SHKRRRETPS PRPMRHRSSR SP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.