Details for: ACAP2

Gene ID: 23527

Symbol: ACAP2

Ensembl ID: ENSG00000114331

Description: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.79
    Marker Score: 1,007
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.72
    Marker Score: 1,351
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.66
    Marker Score: 148,911
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.63
    Marker Score: 56,203
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.6
    Marker Score: 761
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.59
    Marker Score: 10,846
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.57
    Marker Score: 29,911
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.36
    Marker Score: 5,885
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.27
    Marker Score: 2,610
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.21
    Marker Score: 16,441
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.21
    Marker Score: 1,319
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.18
    Marker Score: 32,662
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.16
    Marker Score: 2,452
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.16
    Marker Score: 2,383
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.15
    Marker Score: 2,258
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.12
    Marker Score: 4,127
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.11
    Marker Score: 4,627
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.09
    Marker Score: 79,527
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.09
    Marker Score: 2,519
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.09
    Marker Score: 1,808
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.08
    Marker Score: 76,848
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.08
    Marker Score: 8,635
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.06
    Marker Score: 27,741
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.06
    Marker Score: 40,902
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.05
    Marker Score: 857
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.04
    Marker Score: 9,437
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2
    Marker Score: 1,884
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2
    Marker Score: 5,940
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.99
    Marker Score: 15,285
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.99
    Marker Score: 7,684
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.97
    Marker Score: 8,005
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.96
    Marker Score: 1,287
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.95
    Marker Score: 615
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.94
    Marker Score: 5,541
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.92
    Marker Score: 18,073
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.92
    Marker Score: 1,119
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.9
    Marker Score: 3,656
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 116,445
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.88
    Marker Score: 2,029
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.87
    Marker Score: 1,643
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.87
    Marker Score: 806
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.86
    Marker Score: 4,526
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.85
    Marker Score: 1,601
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.84
    Marker Score: 908
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.84
    Marker Score: 2,375
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18,913
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.83
    Marker Score: 1,334
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.81
    Marker Score: 17,243
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.81
    Marker Score: 1,063
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.81
    Marker Score: 2,669
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.81
    Marker Score: 615
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.81
    Marker Score: 732
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.79
    Marker Score: 60,564
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15,233
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.75
    Marker Score: 1,611
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.74
    Marker Score: 551
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.73
    Marker Score: 639
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.73
    Marker Score: 2,324
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.73
    Marker Score: 4,133
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.7
    Marker Score: 827
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.7
    Marker Score: 1,389
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.69
    Marker Score: 2,040
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.67
    Marker Score: 1,162
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.67
    Marker Score: 2,077
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.66
    Marker Score: 397
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.66
    Marker Score: 715
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.65
    Marker Score: 1,482
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.65
    Marker Score: 2,401
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.65
    Marker Score: 1,592
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.64
    Marker Score: 1,566
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.64
    Marker Score: 568
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.64
    Marker Score: 7,020
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.64
    Marker Score: 447
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.63
    Marker Score: 5,145
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.63
    Marker Score: 1,255
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.63
    Marker Score: 905
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.62
    Marker Score: 802
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.62
    Marker Score: 1,625
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.61
    Marker Score: 315
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.61
    Marker Score: 1,067
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.6
    Marker Score: 349
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.6
    Marker Score: 1,700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.59
    Marker Score: 2,119
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.59
    Marker Score: 1,153
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.59
    Marker Score: 648
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.59
    Marker Score: 1,409
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.59
    Marker Score: 1,963
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.59
    Marker Score: 40,636
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.58
    Marker Score: 2,658
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.58
    Marker Score: 1,610
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.58
    Marker Score: 856
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.58
    Marker Score: 1,576
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.57
    Marker Score: 2,866
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.57
    Marker Score: 2,216
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.56
    Marker Score: 2,719
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.55
    Marker Score: 1,496
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.54
    Marker Score: 810
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.54
    Marker Score: 1,860
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.54
    Marker Score: 2,120
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.53
    Marker Score: 3,695

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ACAP2 is a member of the ArfGAP (ADP-ribosylation factor GTPase-activating protein) family, which is known for its ability to regulate the activity of small GTPases, such as Arf and Rab. The ACAP2 protein contains a unique combination of domains, including a coiled-coil, ankyrin repeat, and PH (pleckstrin homology) domains. These domains confer specific functional properties to the protein, including the ability to interact with various cellular components and regulate membrane trafficking and endocytic processes. **Pathways and Functions:** ACAP2 is involved in several key pathways, including: 1. **Actin filament-based process:** ACAP2 regulates the dynamics of actin filaments, which are essential for cellular movement, migration, and shape changes. 2. **Cellular response to nerve growth factor stimulus:** ACAP2 interacts with nerve growth factor (NGF) receptors, modulating the signaling pathways that regulate neuronal survival and development. 3. **Endocytic recycling:** ACAP2 regulates the endocytic pathway, ensuring the efficient recycling of internalized molecules and maintaining cellular homeostasis. 4. **GTPase activator activity:** ACAP2 activates Arf and Rab GTPases, which are involved in various cellular processes, including membrane trafficking, vesicle formation, and regulation of cell growth. 5. **Membrane and metal ion binding:** ACAP2 interacts with membrane components and metal ions, influencing the organization and function of cellular membranes. **Clinical Significance:** ACAP2 dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** ACAP2 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where dysregulation of endocytic processes and membrane trafficking contribute to disease progression. 2. **Immune cell dysfunction:** ACAP2 plays a critical role in regulating immune cell functions, including the activity of microglial cells and macrophages. Dysregulation of ACAP2 has been linked to immune-related disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** ACAP2 has been implicated in cancer progression, where dysregulation of endocytic processes and membrane trafficking contribute to tumor growth and metastasis. In conclusion, ACAP2 is a multifunctional gene that plays a critical role in regulating immune cell functions, endocytic processes, and membrane trafficking. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying ACAP2 function and its role in human disease.

Genular Protein ID: 2155647611

Symbol: ACAP2_HUMAN

Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

UniProtKB Accession Codes:

Q15057 A8K2V4 Q8N5Z8 Q9UQR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11062263

Title: ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.

PubMed ID: 11062263

DOI: 10.1083/jcb.151.3.627

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 778
  • Mass: 88029
  • Checksum: 64B620957FEE6195
  • Sequence:
    • MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK AFCVANKQFM 
NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ TQRSIKAQLQ NFVKEDLRKF 
KDAKKQFEKV SEEKENALVK NAQVQRNKQH EVEEATNILT ATRKCFRHIA LDYVLQINVL 
QSKRRSEILK SMLSFMYAHL AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ 
KHSTIQQKDF SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK 
KFKDNPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ AWIKAVQTSI 
ATAYREKGDE SEKLDKKSSP STGSLDSGNE SKEKLLKGES ALQRVQCIPG NASCCDCGLA 
DPRWASINLG ITLCIECSGI HRSLGVHFSK VRSLTLDTWE PELLKLMCEL GNDVINRVYE 
ANVEKMGIKK PQPGQRQEKE AYIRAKYVER KFVDKYSISL SPPEQQKKFV SKSSEEKRLS 
ISKFGPGDQV RASAQSSVRS NDSGIQQSSD DGRESLPSTV SANSLYEPEG ERQDSSMFLD 
SKHLNPGLQL YRASYEKNLP KMAEALAHGA DVNWANSEEN KATPLIQAVL GGSLVTCEFL 
LQNGANVNQR DVQGRGPLHH ATVLGHTGQV CLFLKRGANQ HATDEEGKDP LSIAVEAANA 
DIVTLLRLAR MNEEMRESEG LYGQPGDETY QDIFRDFSQM ASNNPEKLNR FQQDSQKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.