Details for: CLCF1

Gene ID: 23529

Symbol: CLCF1

Ensembl ID: ENSG00000175505

Description: cardiotrophin like cytokine factor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.27
    Marker Score: 6,518
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.62
    Marker Score: 3,988
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.43
    Marker Score: 1,505
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.37
    Marker Score: 1,459
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.34
    Marker Score: 11,358
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,790
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.01
    Marker Score: 421
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.98
    Marker Score: 834
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2,271
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.93
    Marker Score: 4,024
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,165
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1,679
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.87
    Marker Score: 256
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,281
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.82
    Marker Score: 204
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.81
    Marker Score: 204
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1,588
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.76
    Marker Score: 595
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 554
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 285
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,855
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,632
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.67
    Marker Score: 22,740
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.66
    Marker Score: 338
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.65
    Marker Score: 3,200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 359
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 643
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.56
    Marker Score: 2,169
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.53
    Marker Score: 1,298
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.45
    Marker Score: 950
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.43
    Marker Score: 152
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.42
    Marker Score: 243
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.4
    Marker Score: 198
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.4
    Marker Score: 102
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.38
    Marker Score: 1,096
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.38
    Marker Score: 238
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.37
    Marker Score: 4,164
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 160
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.35
    Marker Score: 130
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.35
    Marker Score: 380
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.34
    Marker Score: 4,512
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.34
    Marker Score: 773
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.34
    Marker Score: 497
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.34
    Marker Score: 350
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.34
    Marker Score: 76
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.34
    Marker Score: 116
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.33
    Marker Score: 1,188
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.33
    Marker Score: 4,380
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.32
    Marker Score: 205
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.32
    Marker Score: 761
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.31
    Marker Score: 223
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.31
    Marker Score: 70
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.3
    Marker Score: 267
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 77
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.29
    Marker Score: 318
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.29
    Marker Score: 377
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.29
    Marker Score: 312
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 284
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.28
    Marker Score: 508
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.27
    Marker Score: 128
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.27
    Marker Score: 104
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 149
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.26
    Marker Score: 119
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.25
    Marker Score: 198
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.25
    Marker Score: 144
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.25
    Marker Score: 225
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.24
    Marker Score: 376
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.24
    Marker Score: 207
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 228
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.23
    Marker Score: 267
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.22
    Marker Score: 81
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.22
    Marker Score: 89

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLCF1 is a member of the interleukin-6 (IL-6) family of cytokines, characterized by its ability to bind to the IL-6 receptor (IL-6R). This binding event triggers a signaling cascade that activates various transcription factors, leading to the expression of target genes involved in cell proliferation, differentiation, and survival. CLCF1 is primarily expressed in the brain, where it plays a role in the regulation of neuronal survival and differentiation. Additionally, CLCF1 is also expressed in other tissues, including the immune system, where it modulates immune responses and promotes the proliferation of B cells. **Pathways and Functions:** CLCF1 interacts with the IL-6R, triggering a signaling pathway that involves the activation of Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins. This pathway is involved in various cellular processes, including: 1. **Cell proliferation and differentiation**: CLCF1 promotes the proliferation of B cells, astrocytes, and other cell types, while inhibiting apoptosis in neurons. 2. **Immune response modulation**: CLCF1 modulates immune responses by promoting the proliferation of B cells and the production of immunoglobulins. 3. **Neuroprotection**: CLCF1 protects neurons from apoptosis, promoting their survival and differentiation. 4. **Growth factor activity**: CLCF1 exhibits growth factor activity, promoting the proliferation and differentiation of various cell types. **Signaling Pathways:** CLCF1 interacts with the following signaling pathways: 1. **IL-6R signaling pathway**: CLCF1 binds to the IL-6R, triggering a signaling cascade that activates JAK and STAT proteins. 2. **CRLF-CLCF1 complex**: CLCF1 interacts with the CRLF (cardiotrophin receptor-like factor) protein, modulating its signaling activity. 3. **Cntfr-CLCF1 complex**: CLCF1 interacts with the Cntfr (cardiotrophin receptor) protein, modulating its signaling activity. **Clinical Significance:** CLCF1 has potential therapeutic applications in various diseases, including: 1. **Autoimmune disorders**: CLCF1 may be used to modulate immune responses in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurodegenerative diseases**: CLCF1 may be used to promote neuronal survival and differentiation in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CLCF1 may be used to modulate immune responses and promote the proliferation of cancer cells, potentially leading to improved treatment outcomes. In conclusion, CLCF1 is a multifunctional growth factor that plays a crucial role in various biological processes, including immune response, cell differentiation, and survival. Its potential therapeutic applications in autoimmune disorders, neurodegenerative diseases, and cancer make it an exciting area of research for immunologists and clinicians alike.

Genular Protein ID: 2250667807

Symbol: CLCF1_HUMAN

Name: Cardiotrophin-like cytokine factor 1

UniProtKB Accession Codes:

Q9UBD9 B4DNT4 Q6NZA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 2 Ensembl 2 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10500198

Title: Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family.

PubMed ID: 10500198

DOI: 10.1073/pnas.96.20.11458

PubMed ID: 10448081

Title: Computational EST database analysis identifies a novel member of the neuropoietic cytokine family.

PubMed ID: 10448081

DOI: 10.1006/bbrc.1999.1181

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 16782820

Title: Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

PubMed ID: 16782820

DOI: 10.1073/pnas.0509598103

Sequence Information:

  • Length: 225
  • Mass: 25176
  • Checksum: E2DD4B6280833B55
  • Sequence:
    • MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL EHQLRSLAGT 
YLNYLGPPFN EPDFNPPRLG AETLPRATVD LEVWRSLNDK LRLTQNYEAY SHLLCYLRGL 
NRQAATAELR RSLAHFCTSL QGLLGSIAGV MAALGYPLPQ PLPGTEPTWT PGPAHSDFLQ 
KMDDFWLLKE LQTWLWRSAK DFNRLKKKMQ PPAAAVTLHL GAHGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.