Details for: NNT

Gene ID: 23530

Symbol: NNT

Ensembl ID: ENSG00000112992

Description: nicotinamide nucleotide transhydrogenase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.11
    Marker Score: 69,529
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.25
    Marker Score: 1,187
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.13
    Marker Score: 4,672
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.01
    Marker Score: 5,396
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.98
    Marker Score: 2,096
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.97
    Marker Score: 72,539
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.91
    Marker Score: 7,911
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.89
    Marker Score: 3,138
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.86
    Marker Score: 6,601
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.84
    Marker Score: 1,069
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.83
    Marker Score: 112,497
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.79
    Marker Score: 68,011
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7,109
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.74
    Marker Score: 6,716
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14,713
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.71
    Marker Score: 16,264
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.71
    Marker Score: 34,009
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.71
    Marker Score: 16,044
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.67
    Marker Score: 17,195
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.66
    Marker Score: 24,810
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.63
    Marker Score: 34,875
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.62
    Marker Score: 12,399
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.61
    Marker Score: 4,027
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.59
    Marker Score: 7,378
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,375
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.54
    Marker Score: 6,629
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.52
    Marker Score: 9,742
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.47
    Marker Score: 7,896
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.39
    Marker Score: 1,111
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.39
    Marker Score: 405
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.38
    Marker Score: 503
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.38
    Marker Score: 46,468
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.37
    Marker Score: 576
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.32
    Marker Score: 736
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.29
    Marker Score: 3,262
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19,552
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.23
    Marker Score: 5,138
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.21
    Marker Score: 935
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.2
    Marker Score: 2,311
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.13
    Marker Score: 3,212
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.12
    Marker Score: 356
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.11
    Marker Score: 3,023
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.11
    Marker Score: 1,572
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.11
    Marker Score: 302
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.1
    Marker Score: 1,262
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.09
    Marker Score: 529
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.07
    Marker Score: 1,024
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.07
    Marker Score: 924
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.05
    Marker Score: 712
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.03
    Marker Score: 1,047
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.02
    Marker Score: 393
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.02
    Marker Score: 380
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.02
    Marker Score: 506
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.01
    Marker Score: 1,093
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.01
    Marker Score: 256
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,670
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,895
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 998
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.99
    Marker Score: 2,321
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.98
    Marker Score: 568
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.97
    Marker Score: 1,209
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.96
    Marker Score: 656
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.95
    Marker Score: 1,179
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.95
    Marker Score: 312
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.95
    Marker Score: 504
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.94
    Marker Score: 465
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.93
    Marker Score: 992
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.92
    Marker Score: 516
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.92
    Marker Score: 9,280
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.91
    Marker Score: 289
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,696
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9
    Marker Score: 1,015
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,087
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.89
    Marker Score: 562
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.88
    Marker Score: 2,105
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.87
    Marker Score: 275
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.86
    Marker Score: 293
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 510
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.84
    Marker Score: 553
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.84
    Marker Score: 1,411
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.84
    Marker Score: 310
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.84
    Marker Score: 768
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.83
    Marker Score: 2,957
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.83
    Marker Score: 4,356
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.83
    Marker Score: 218
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.82
    Marker Score: 334
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.82
    Marker Score: 13,203
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4,938
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.82
    Marker Score: 2,011
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.82
    Marker Score: 309
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.81
    Marker Score: 504
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8
    Marker Score: 14,273
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.79
    Marker Score: 4,251

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NNT is a mitochondrial enzyme that exhibits high specificity for NAD+ and NADP+ as substrates. It is a tetrameric protein composed of two identical subunits, each containing a flavin adenine dinucleotide (FAD) cofactor. NNT is widely expressed in various tissues, including the heart, kidney, and brain, where it is found in high concentrations. This enzyme is also highly conserved across species, suggesting its importance in maintaining fundamental cellular processes. **Pathways and Functions:** NNT is involved in several critical cellular pathways, including: 1. **Cell Redox Homeostasis:** NNT regulates the balance of reducing equivalents within the cell by facilitating the interconversion of NAD+ and NADP+. This enzyme helps maintain the proper redox state of the cell, preventing oxidative stress and damage. 2. **Cellular Oxidant Detoxification:** NNT plays a role in the detoxification of reactive oxygen species (ROS), which are harmful to cells. By reducing NADP+, NNT helps neutralize ROS and prevent oxidative damage. 3. **Citric Acid Cycle (TCA Cycle):** NNT is involved in the regulation of the TCA cycle, which is a critical metabolic pathway that produces energy for the cell. By facilitating the transfer of electrons between NAD+ and NADP+, NNT helps maintain the proper functioning of the TCA cycle. 4. **Mitochondrial Inner Membrane:** NNT is localized to the mitochondrial inner membrane, where it plays a key role in regulating the mitochondrial membrane potential. This is essential for maintaining the proper functioning of the mitochondria, which are the primary site of energy production in cells. **Clinical Significance:** Dysregulation of NNT has been implicated in various diseases, including: 1. **Mitochondrial Diseases:** Mutations in the NNT gene have been associated with mitochondrial diseases, such as mitochondrial myopathies and encephalopathies. 2. **Cardiovascular Diseases:** NNT has been shown to play a role in the regulation of cardiac function, and its dysregulation has been implicated in the development of cardiovascular diseases, such as heart failure. 3. **Neurological Disorders:** NNT has been implicated in the regulation of neuronal function, and its dysregulation has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, NNT is a critical enzyme involved in maintaining cellular redox homeostasis and mitochondrial function. Its dysregulation has been implicated in various diseases, highlighting the importance of NNT in human health and disease. Further research is needed to fully understand the mechanisms of NNT and its role in human disease.

Genular Protein ID: 3823915336

Symbol: NNTM_HUMAN

Name: NAD(P) transhydrogenase, mitochondrial

UniProtKB Accession Codes:

Q13423 Q16796 Q2TB60 Q8N3V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 17 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 4 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9524818

Title: Cloning and deduced amino acid sequence of human nicotinamide nucleotide transhydrogenase.

PubMed ID: 9524818

DOI: 10.3109/10425179709034058

PubMed ID: 8616157

Title: The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse.

PubMed ID: 8616157

DOI: 10.1016/0005-2728(95)00159-x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22634753

Title: Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.

PubMed ID: 22634753

DOI: 10.1038/ng.2299

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10673423

Title: The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria.

PubMed ID: 10673423

DOI: 10.1016/s0969-2126(00)00075-7

PubMed ID: 12791694

Title: Interactions between transhydrogenase and thio-nicotinamide Analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation.

PubMed ID: 12791694

DOI: 10.1074/jbc.m303061200

PubMed ID: 15323555

Title: Active-site conformational changes associated with hydride transfer in proton-translocating transhydrogenase.

PubMed ID: 15323555

DOI: 10.1021/bi0497594

Sequence Information:

  • Length: 1086
  • Mass: 113896
  • Checksum: 8A437658CA0EB41B
  • Sequence:
    • MANLLKTVVT GCSCPLLSNL GSCKGLRVKK DFLRTFYTHQ ELWCKAPVKP GIPYKQLTVG 
VPKEIFQNEK RVALSPAGVQ NLVKQGFNVV VESGAGEASK FSDDHYRVAG AQIQGAKEVL 
ASDLVVKVRA PMVNPTLGVH EADLLKTSGT LISFIYPAQN PELLNKLSQR KTTVLAMDQV 
PRVTIAQGYD ALSSMANIAG YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL 
ASAGAAKSMG AIVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE 
MKLFAQQCKE VDILISTALI PGKKAPVLFN KEMIESMKEG SVVVDLAAEA GGNFETTKPG 
ELYIHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS PDKDNFYFDV KDDFDFGTMG 
HVIRGTVVMK DGKVIFPAPT PKNIPQGAPV KQKTVAELEA EKAATITPFR KTMSTASAYT 
AGLTGILGLG IAAPNLAFSQ MVTTFGLAGI VGYHTVWGVT PALHSPLMSV TNAISGLTAV 
GGLALMGGHL YPSTTSQGLA ALAAFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL 
PAGTFVGGYL AALYSGYNIE QIMYLGSGLC CVGALAGLST QGTARLGNAL GMIGVAGGLA 
ATLGVLKPGP ELLAQMSGAM ALGGTIGLTI AKRIQISDLP QLVAAFHSLV GLAAVLTCIA 
EYIIEYPHFA TDAAANLTKI VAYLGTYIGG VTFSGSLIAY GKLQGLLKSA PLLLPGRHLL 
NAGLLAASVG GIIPFMVDPS FTTGITCLGS VSALSAVMGV TLTAAIGGAD MPVVITVLNS 
YSGWALCAEG FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG 
KPMEISGTHT EINLDNAIDM IREANSIIIT PGYGLCAAKA QYPIADLVKM LTEQGKKVRF 
GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINHDFPDT DLVLVIGAND TVNSAAQEDP 
NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA AVDNPIFYKP NTAMLLGDAK KTCDALQAKV 
RESYQK

Genular Protein ID: 923867736

Symbol: E9PCX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PCX7

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 MaxQB 2 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 955
  • Mass: 99729
  • Checksum: AA59856439D9CE1C
  • Sequence:
    • MVNPTLGVHE ADLLKTSGTL ISFIYPAQNP ELLNKLSQRK TTVLAMDQVP RVTIAQGYDA 
LSSMANIAGY KAVVLAANHF GRFFTGQITA AGKVPPAKIL IVGGGVAGLA SAGAAKSMGA 
IVRGFDTRAA ALEQFKSLGA EPLEVDLKES GEGQGGYAKE MSKEFIEAEM KLFAQQCKEV 
DILISTALIP GKKAPVLFNK EMIESMKEGS VVVDLAAEAG GNFETTKPGE LYIHKGITHI 
GYTDLPSRMA TQASTLYSNN ITKLLKAISP DKDNFYFDVK DDFDFGTMGH VIRGTVVMKD 
GKVIFPAPTP KNIPQGAPVK QKTVAELEAE KAATITPFRK TMSTASAYTA GLTGILGLGI 
AAPNLAFSQM VTTFGLAGIV GYHTVWGVTP ALHSPLMSVT NAISGLTAVG GLALMGGHLY 
PSTTSQGLAA LAAFISSVNI AGGFLVTQRM LDMFKRPTDP PEYNYLYLLP AGTFVGGYLA 
ALYSGYNIEQ IMYLGSGLCC VGALAGLSTQ GTARLGNALG MIGVAGGLAA TLGVLKPGPE 
LLAQMSGAMA LGGTIGLTIA KRIQISDLPQ LVAAFHSLVG LAAVLTCIAE YIIEYPHFAT 
DAAANLTKIV AYLGTYIGGV TFSGSLIAYG KLQGLLKSAP LLLPGRHLLN AGLLAASVGG 
IIPFMVDPSF TTGITCLGSV SALSAVMGVT LTAAIGGADM PVVITVLNSY SGWALCAEGF 
LLNNNLLTIV GALIGSSGAI LSYIMCVAMN RSLANVILGG YGTTSTAGGK PMEISGTHTE 
INLDNAIDMI REANSIIITP GYGLCAAKAQ YPIADLVKML TEQGKKVRFG IHPVAGRMPG 
QLNVLLAEAG VPYDIVLEMD EINHDFPDTD LVLVIGANDT VNSAAQEDPN SIIAGMPVLE 
VWKSKQVIVM KRSLGVGYAA VDNPIFYKPN TAMLLGDAKK TCDALQAKVR ESYQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.