Details for: MMD

Gene ID: 23531

Symbol: MMD

Ensembl ID: ENSG00000108960

Description: monocyte to macrophage differentiation associated

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.03
    Marker Score: 2,279
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.55
    Marker Score: 14,683
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.38
    Marker Score: 2,811
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.33
    Marker Score: 1,061
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.21
    Marker Score: 507
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,286
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.15
    Marker Score: 2,172
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.14
    Marker Score: 416
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.08
    Marker Score: 66,444
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.07
    Marker Score: 1,071
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.05
    Marker Score: 615
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,974
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.98
    Marker Score: 25,156
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.98
    Marker Score: 9,236
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8,363
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.97
    Marker Score: 325
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,714
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.89
    Marker Score: 421
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,974
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.87
    Marker Score: 517
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.86
    Marker Score: 8,853
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.85
    Marker Score: 192
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.85
    Marker Score: 2,335
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 474
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.79
    Marker Score: 249
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.78
    Marker Score: 389
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.77
    Marker Score: 828
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.77
    Marker Score: 431
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.75
    Marker Score: 411
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.75
    Marker Score: 735
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.74
    Marker Score: 695
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.74
    Marker Score: 1,253
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 237
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.73
    Marker Score: 691
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.73
    Marker Score: 1,279
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.73
    Marker Score: 437
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.72
    Marker Score: 294
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.71
    Marker Score: 1,475
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.7
    Marker Score: 1,989
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.7
    Marker Score: 437
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.69
    Marker Score: 363
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.69
    Marker Score: 839
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,894
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.68
    Marker Score: 674
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.68
    Marker Score: 2,767
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.67
    Marker Score: 1,405
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.67
    Marker Score: 491
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.66
    Marker Score: 619
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.64
    Marker Score: 317
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.63
    Marker Score: 307
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.63
    Marker Score: 862
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.61
    Marker Score: 1,652
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.61
    Marker Score: 3,691
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6
    Marker Score: 1,790
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.6
    Marker Score: 318
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.58
    Marker Score: 900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.58
    Marker Score: 313
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 278
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.58
    Marker Score: 611
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.57
    Marker Score: 963
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.57
    Marker Score: 258
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1,331
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.56
    Marker Score: 598
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.56
    Marker Score: 974
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.55
    Marker Score: 346
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.54
    Marker Score: 261
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 850
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.52
    Marker Score: 296
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.52
    Marker Score: 511
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.52
    Marker Score: 390
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.52
    Marker Score: 187
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.52
    Marker Score: 350
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.51
    Marker Score: 584
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.51
    Marker Score: 338
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5
    Marker Score: 2,987
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5
    Marker Score: 3,204
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 330
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.5
    Marker Score: 906
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.5
    Marker Score: 157
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.48
    Marker Score: 6,494
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.48
    Marker Score: 167
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.48
    Marker Score: 1,174
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.48
    Marker Score: 206
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 209

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MMD gene is a transcription factor that regulates the expression of genes involved in the monocyte to macrophage differentiation process. This process is essential for the development of immune cells that can recognize and eliminate pathogens. The MMD gene is highly expressed in cells of the peripheral nervous system, including neurons and glial cells, as well as in various immune cells such as macrophages and dendritic cells. **Pathways and Functions:** The MMD gene is involved in several signaling pathways that regulate cellular differentiation, migration, and survival. These pathways include: 1. **Golgi apparatus and Late endosome membrane**: The MMD gene regulates the expression of genes involved in the processing and secretion of proteins, which is essential for the development of immune cells. 2. **Lysosomal membrane**: The MMD gene regulates the expression of genes involved in the degradation and recycling of cellular waste, which is essential for the maintenance of immune cells. 3. **Membrane and Plasma membrane**: The MMD gene regulates the expression of genes involved in cell-cell interactions and signaling, which is essential for the development of immune cells. 4. **Pore-forming activity**: The MMD gene regulates the expression of genes involved in the formation of pores in the cell membrane, which is essential for the release of signaling molecules. 5. **Positive regulation of neuron differentiation**: The MMD gene regulates the expression of genes involved in the development of neurons, which is essential for the development of the nervous system. 6. **Positive regulation of protein kinase activity**: The MMD gene regulates the expression of genes involved in the activation of protein kinases, which is essential for the regulation of cellular signaling pathways. 7. **Protein binding**: The MMD gene regulates the expression of genes involved in protein-protein interactions, which is essential for the regulation of cellular signaling pathways. 8. **Protein kinase activity**: The MMD gene regulates the expression of genes involved in the regulation of protein kinases, which is essential for the regulation of cellular signaling pathways. 9. **Regulation of protein localization**: The MMD gene regulates the expression of genes involved in the localization of proteins within the cell, which is essential for the regulation of cellular signaling pathways. 10. **Signaling receptor activity**: The MMD gene regulates the expression of genes involved in the activation of signaling receptors, which is essential for the regulation of cellular signaling pathways. **Clinical Significance:** The MMD gene has been implicated in various diseases, including: 1. **Autoimmune diseases**: The MMD gene has been shown to play a role in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. 2. **Infectious diseases**: The MMD gene has been shown to play a role in the development of infectious diseases such as tuberculosis and HIV. 3. **Cancer**: The MMD gene has been shown to play a role in the development of cancer, including leukemia and lymphoma. 4. **Neurological disorders**: The MMD gene has been shown to play a role in the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, the MMD gene is a critical regulator of monocyte to macrophage differentiation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of the MMD gene in immune response and cellular regulation, and to develop new therapeutic strategies for the treatment of diseases associated with MMD gene dysfunction.

Genular Protein ID: 379700388

Symbol: PAQRB_HUMAN

Name: Progestin and adipoQ receptor family member XI

UniProtKB Accession Codes:

Q15546 B2R6X9 D3DTY6 Q8TAN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7503749

Title: Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains.

PubMed ID: 7503749

DOI: 10.1006/bbrc.1995.2825

PubMed ID: 16044242

Title: PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.

PubMed ID: 16044242

DOI: 10.1007/s00239-004-0375-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 238
  • Mass: 27667
  • Checksum: 0B7328C85911F184
  • Sequence:
    • MRFKNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH RLSDDCWEKI 
TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD RMVIYFFIAA SYAPWLNLRE 
LGPLASHMRW FIWLMAAGGT IYVFLYHEKY KVVELFFYLT MGFSPALVVT SMNNTDGLQE 
LACGGLIYCL GVVFFKSDGI IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFMRHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.