Details for: PRAME
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 4.32
Marker Score: 7,549 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.16
Marker Score: 3,178 - Cell Name: oogonial cell (CL0000024)
Fold Change: 2.48
Marker Score: 3,570 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.01
Marker Score: 2,001 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.94
Marker Score: 558 - Cell Name: oocyte (CL0000023)
Fold Change: 1.69
Marker Score: 419 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.67
Marker Score: 2,098 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1,174 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.35
Marker Score: 710 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 859 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 490 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7,671 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,822 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.14
Marker Score: 6,881 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,816 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,833 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,058 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 512 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,409 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Marker Score: 449 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 376 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,352 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.91
Marker Score: 5,410 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.88
Marker Score: 1,430 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.86
Marker Score: 655 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 465 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.72
Marker Score: 476 - Cell Name: mast cell (CL0000097)
Fold Change: 0.71
Marker Score: 410 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 495 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.59
Marker Score: 20,416 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.54
Marker Score: 227 - Cell Name: glial cell (CL0000125)
Fold Change: 0.49
Marker Score: 536 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.48
Marker Score: 1,174 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.45
Marker Score: 925 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.44
Marker Score: 424 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 243 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 374 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.32
Marker Score: 85 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.24
Marker Score: 135 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.21
Marker Score: 336 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.2
Marker Score: 347 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.17
Marker Score: 63 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.16
Marker Score: 169 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.16
Marker Score: 159 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.14
Marker Score: 1,191 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.13
Marker Score: 1,800 - Cell Name: macrophage (CL0000235)
Fold Change: 0.12
Marker Score: 129 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.11
Marker Score: 118 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.11
Marker Score: 34 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1
Marker Score: 23 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.09
Marker Score: 50 - Cell Name: theca cell (CL0000503)
Fold Change: 0.09
Marker Score: 65 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.09
Marker Score: 55 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.09
Marker Score: 55 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.09
Marker Score: 83 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.09
Marker Score: 40 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.07
Marker Score: 24 - Cell Name: dendritic cell (CL0000451)
Fold Change: 0.07
Marker Score: 51 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.07
Marker Score: 66 - Cell Name: T cell (CL0000084)
Fold Change: 0.07
Marker Score: 122 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.07
Marker Score: 712 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.07
Marker Score: 35 - Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 64 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.06
Marker Score: 26 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.06
Marker Score: 58 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.06
Marker Score: 16 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.06
Marker Score: 93 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.06
Marker Score: 58 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.06
Marker Score: 19 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.06
Marker Score: 120 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.06
Marker Score: 17 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.06
Marker Score: 14 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.06
Marker Score: 131 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.05
Marker Score: 89 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.05
Marker Score: 17 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.05
Marker Score: 37 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.05
Marker Score: 87 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.05
Marker Score: 45 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.05
Marker Score: 31 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.05
Marker Score: 36 - Cell Name: basophil mast progenitor cell (CL0002028)
Fold Change: 0.05
Marker Score: 16 - Cell Name: eosinophil (CL0000771)
Fold Change: 0.05
Marker Score: 17 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.05
Marker Score: 17 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.05
Marker Score: 50 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.05
Marker Score: 161 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.04
Marker Score: 50 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.04
Marker Score: 20 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.04
Marker Score: 18
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1062961544
Symbol: PRAME_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9047241
Title: Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.
PubMed ID: 9047241
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9466265
Title: Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.
PubMed ID: 9466265
PubMed ID: 16179254
Title: The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
PubMed ID: 16179254
PubMed ID: 16620968
Title: PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma.
PubMed ID: 16620968
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21822215
Title: The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
PubMed ID: 21822215
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23460923
Title: PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.
PubMed ID: 23460923
PubMed ID: 26138980
Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.
PubMed ID: 26138980
Sequence Information:
- Length: 509
- Mass: 57890
- Checksum: B5FFF3E7F7E82606
- Sequence:
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV WLSANPCPHC GDRTFYDPEP ILCPCFMPN
Genular Protein ID: 2414463475
Symbol: B7Z986_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 452
- Mass: 51295
- Checksum: 206DE821E621AA57
- Sequence:
MAAFDGRHSQ TLKAMVQAWP FTCLPLGVLM KGQHLHLETF KAVLDGLDVL LAQEVRPRRW KLQVLDLRKN SHQDFWTVWS GNRASLYSFP EPEAAQPMTK KRKVDGLSTE AEQPFIPVEV LVDLFLKEGA CDELFSYLIE KVKRKKNVLR LCCKKLKIFA MPMQDIKMIL KMVQLDSIED LEVTCTWKLP TLAKFSPYLG QMINLRRLLL SHIHASSYIS PEKEEQYIAQ FTSQFLSLQC LQALYVDSLF FLRGRLDQLL RHVMNPLETL SITNCRLSEG DVMHLSQSPS VSQLSVLSLS GVMLTDVSPE PLQALLERAS ATLQDLVFDE CGITDDQLLA LLPSLSHCSQ LTTLSFYGNS ISISALQSLL QHLIGLSNLT HVLYPVPLES YEDIHGTLHL ERLAYLHARL RELLCELGRP SMVWLSANPC PHCGDRTFYD PEPILCPCFM PN
Genular Protein ID: 3530634982
Symbol: B7ZAT0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 493
- Mass: 55883
- Checksum: 34CAF80C12D1E7F6
- Sequence:
MSVWTSPRRL VELAGQSLLK DEALAIAALE LLPRELFPPL FMAAFDGRHS QTLKAMVQAW PFTCLPLGVL MKGQHLHLET FKAVLDGLDV LLAQEVRPRR WKLQVLDLRK NSHQDFWTVW SGNRASLYSF PEPEAAQPMT KKRKVDGLST EAEQPFIPVE VLVDLFLKEG ACDELFSYLI EKVKRKKNVL RLCCKKLKIF AMPMQDIKMI LKMVQLDSIE DLEVTCTWKL PTLAKFSPYL GQMINLRRLL LSHIHASSYI SPEKEEQYIA QFTSQFLSLQ CLQALYVDSL FFLRGRLDQL LRHVMNPLET LSITNCRLSE GDVMHLSQSP SVSQLSVLSL SGVMLTDLSP EPLQALLERA SATLQDLVFD ECGITDDQLL ALLPSLSHCS QLTTLSFYGN SISISALQSL LQHLIGLSNL THVLYPVPLE SYEDIHGTLH LERLAYLHAR LRELLCELGR PSMVWLSANP CPHCGDRTFY DPEPILCPCF MPN
Genular Protein ID: 578971804
Symbol: B7Z7K8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 493
- Mass: 55931
- Checksum: 084F6C8B6A5F369F
- Sequence:
MSVWTSPRRL VELAGQSLLK DEALAIAALE LLPRELFPPL FMAAFDGRHS QTLKAMVQAW PFTCLPLGVL MKGQHLHLET FKAVFDGLDV LLAQEVRPRR WKLQVLDLRK NSHQDFWTVW SGNRASLYSF PEPEAAQPMT KKRKVDGLST EAEQPFIPVE VLVDLFLKEG ACDELFSYLI EKVKRRKNVL RLCCKKLKIF AMPMQDIKMI LKMVQLDSIE DLEVTCTWKL PTLAKFSPYL GQMINLRRLL LSHIHASSYI SPEKEEQYIA QFTSQFLSLQ CLQALYVDSL FFLRGRLDQL LRHVMNPLET LSITNCRLSE GDVMHLSQSP SVSQLSVLSL SGVMLTDVSP EPLQALLERA SATLQDLVFD ECGITDDQLL ALLPSLSHCS QLTTLSFYGN SISISALQSL LQHLIGLSNL THVLYPVPLE SYEDIHGTLH LERLAYLHAR LRELLCELGR PSMVWLSANP CPHCGDRTFY DPEPILCPCF MPN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.