Details for: PRAME

Gene ID: 23532

Symbol: PRAME

Ensembl ID: ENSG00000185686

Description: PRAME nuclear receptor transcriptional regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.32
    Marker Score: 7,549
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,178
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.48
    Marker Score: 3,570
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2,001
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.94
    Marker Score: 558
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.69
    Marker Score: 419
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.67
    Marker Score: 2,098
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,174
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.35
    Marker Score: 710
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,671
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,822
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.14
    Marker Score: 6,881
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,816
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.91
    Marker Score: 5,410
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1,430
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 655
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 476
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.71
    Marker Score: 410
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 495
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.59
    Marker Score: 20,416
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 227
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.49
    Marker Score: 536
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.48
    Marker Score: 1,174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.45
    Marker Score: 925
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 424
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 243
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.24
    Marker Score: 135
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.21
    Marker Score: 336
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 347
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.16
    Marker Score: 169
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.16
    Marker Score: 159
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.14
    Marker Score: 1,191
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.13
    Marker Score: 1,800
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 129
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 122
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.07
    Marker Score: 712
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.06
    Marker Score: 93
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 120
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 131
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.05
    Marker Score: 89
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 87
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 161
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 18

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRAME is a nuclear receptor transcriptional regulator that is expressed in various cell types, including germ cells, blood vessel endothelial cells, oogonial cells, enterocytes, and hematopoietic stem cells. It is also involved in the regulation of cell population proliferation and has been implicated in the negative regulation of apoptotic and cell differentiation processes. PRAME is a member of the nuclear receptor superfamily and shares structural homology with other nuclear receptors, such as RAR and RXR. **Pathways and Functions:** PRAME is involved in several cellular pathways, including: 1. **Apoptotic process**: PRAME regulates the negative regulation of apoptotic processes, which is essential for maintaining immune homeostasis and preventing excessive cell death. 2. **Cell differentiation**: PRAME plays a crucial role in regulating cell differentiation, particularly in the development of germ cells and hematopoietic stem cells. 3. **DNA-templated transcription**: PRAME is involved in the regulation of DNA-templated transcription, which is essential for gene expression and cellular function. 4. **Retinoic acid receptor signaling pathway**: PRAME negatively regulates the retinoic acid receptor signaling pathway, which is crucial for embryonic development and tissue homeostasis. PRAME's functions can be summarized as follows: * **Cell survival**: PRAME promotes cell survival by regulating the negative regulation of apoptotic processes. * **Cell proliferation**: PRAME regulates cell population proliferation, which is essential for maintaining immune homeostasis. * **Cell differentiation**: PRAME plays a crucial role in regulating cell differentiation, particularly in the development of germ cells and hematopoietic stem cells. **Clinical Significance:** PRAME has been implicated in various diseases, including: 1. **Cancer**: PRAME is overexpressed in several types of cancer, including leukemia, lymphoma, and colon cancer, suggesting its potential role in tumorigenesis. 2. **Autoimmune diseases**: PRAME has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting its potential role in immune homeostasis. 3. **Neurological disorders**: PRAME has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in neuroprotection. In conclusion, PRAME is a critical regulator of immune homeostasis and disease. Further research is needed to fully understand its role in various cellular processes and its implications in disease.

Genular Protein ID: 1062961544

Symbol: PRAME_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9047241

Title: Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.

PubMed ID: 9047241

DOI: 10.1016/s1074-7613(00)80426-4

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9466265

Title: Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.

PubMed ID: 9466265

DOI: 10.1046/j.1365-2958.1998.00670.x

PubMed ID: 16179254

Title: The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

PubMed ID: 16179254

DOI: 10.1016/j.cell.2005.07.003

PubMed ID: 16620968

Title: PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma.

PubMed ID: 16620968

DOI: 10.1016/j.leukres.2006.02.031

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21822215

Title: The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.

PubMed ID: 21822215

DOI: 10.1038/emboj.2011.262

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23460923

Title: PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.

PubMed ID: 23460923

DOI: 10.1371/journal.pone.0058052

PubMed ID: 26138980

Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PubMed ID: 26138980

DOI: 10.1126/science.aab0515

Sequence Information:

  • Length: 509
  • Mass: 57890
  • Checksum: B5FFF3E7F7E82606
  • Sequence:
  • MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA 
    FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ 
    VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD 
    LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV 
    TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA 
    LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM 
    LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI 
    SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV 
    WLSANPCPHC GDRTFYDPEP ILCPCFMPN

Genular Protein ID: 2414463475

Symbol: B7Z986_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 452
  • Mass: 51295
  • Checksum: 206DE821E621AA57
  • Sequence:
  • MAAFDGRHSQ TLKAMVQAWP FTCLPLGVLM KGQHLHLETF KAVLDGLDVL LAQEVRPRRW 
    KLQVLDLRKN SHQDFWTVWS GNRASLYSFP EPEAAQPMTK KRKVDGLSTE AEQPFIPVEV 
    LVDLFLKEGA CDELFSYLIE KVKRKKNVLR LCCKKLKIFA MPMQDIKMIL KMVQLDSIED 
    LEVTCTWKLP TLAKFSPYLG QMINLRRLLL SHIHASSYIS PEKEEQYIAQ FTSQFLSLQC 
    LQALYVDSLF FLRGRLDQLL RHVMNPLETL SITNCRLSEG DVMHLSQSPS VSQLSVLSLS 
    GVMLTDVSPE PLQALLERAS ATLQDLVFDE CGITDDQLLA LLPSLSHCSQ LTTLSFYGNS 
    ISISALQSLL QHLIGLSNLT HVLYPVPLES YEDIHGTLHL ERLAYLHARL RELLCELGRP 
    SMVWLSANPC PHCGDRTFYD PEPILCPCFM PN

Genular Protein ID: 3530634982

Symbol: B7ZAT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 493
  • Mass: 55883
  • Checksum: 34CAF80C12D1E7F6
  • Sequence:
  • MSVWTSPRRL VELAGQSLLK DEALAIAALE LLPRELFPPL FMAAFDGRHS QTLKAMVQAW 
    PFTCLPLGVL MKGQHLHLET FKAVLDGLDV LLAQEVRPRR WKLQVLDLRK NSHQDFWTVW 
    SGNRASLYSF PEPEAAQPMT KKRKVDGLST EAEQPFIPVE VLVDLFLKEG ACDELFSYLI 
    EKVKRKKNVL RLCCKKLKIF AMPMQDIKMI LKMVQLDSIE DLEVTCTWKL PTLAKFSPYL 
    GQMINLRRLL LSHIHASSYI SPEKEEQYIA QFTSQFLSLQ CLQALYVDSL FFLRGRLDQL 
    LRHVMNPLET LSITNCRLSE GDVMHLSQSP SVSQLSVLSL SGVMLTDLSP EPLQALLERA 
    SATLQDLVFD ECGITDDQLL ALLPSLSHCS QLTTLSFYGN SISISALQSL LQHLIGLSNL 
    THVLYPVPLE SYEDIHGTLH LERLAYLHAR LRELLCELGR PSMVWLSANP CPHCGDRTFY 
    DPEPILCPCF MPN

Genular Protein ID: 578971804

Symbol: B7Z7K8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 493
  • Mass: 55931
  • Checksum: 084F6C8B6A5F369F
  • Sequence:
  • MSVWTSPRRL VELAGQSLLK DEALAIAALE LLPRELFPPL FMAAFDGRHS QTLKAMVQAW 
    PFTCLPLGVL MKGQHLHLET FKAVFDGLDV LLAQEVRPRR WKLQVLDLRK NSHQDFWTVW 
    SGNRASLYSF PEPEAAQPMT KKRKVDGLST EAEQPFIPVE VLVDLFLKEG ACDELFSYLI 
    EKVKRRKNVL RLCCKKLKIF AMPMQDIKMI LKMVQLDSIE DLEVTCTWKL PTLAKFSPYL 
    GQMINLRRLL LSHIHASSYI SPEKEEQYIA QFTSQFLSLQ CLQALYVDSL FFLRGRLDQL 
    LRHVMNPLET LSITNCRLSE GDVMHLSQSP SVSQLSVLSL SGVMLTDVSP EPLQALLERA 
    SATLQDLVFD ECGITDDQLL ALLPSLSHCS QLTTLSFYGN SISISALQSL LQHLIGLSNL 
    THVLYPVPLE SYEDIHGTLH LERLAYLHAR LRELLCELGR PSMVWLSANP CPHCGDRTFY 
    DPEPILCPCF MPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.