Details for: PIK3R5

Gene ID: 23533

Symbol: PIK3R5

Ensembl ID: ENSG00000141506

Description: phosphoinositide-3-kinase regulatory subunit 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.27
    Marker Score: 1,129
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.24
    Marker Score: 811
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,146
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,678
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.38
    Marker Score: 446
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 769
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,778
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.14
    Marker Score: 472
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.1
    Marker Score: 3,479
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1
    Marker Score: 61,604
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,780
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,004
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.99
    Marker Score: 1,928
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.99
    Marker Score: 1,132
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 659
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,252
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.91
    Marker Score: 1,660
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.9
    Marker Score: 903
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 404
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,272
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.87
    Marker Score: 2,099
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13,314
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.85
    Marker Score: 1,247
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.8
    Marker Score: 706
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.8
    Marker Score: 1,945
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.8
    Marker Score: 4,836
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.77
    Marker Score: 334
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.77
    Marker Score: 1,068
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,243
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.76
    Marker Score: 231
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.76
    Marker Score: 39,970
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.73
    Marker Score: 263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.73
    Marker Score: 2,035
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.71
    Marker Score: 18,305
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 448
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1,070
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.67
    Marker Score: 337
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.67
    Marker Score: 485
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.66
    Marker Score: 737
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.66
    Marker Score: 2,817
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.65
    Marker Score: 869
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.64
    Marker Score: 7,435
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.63
    Marker Score: 2,019
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.63
    Marker Score: 641
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.63
    Marker Score: 194
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.62
    Marker Score: 455
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.61
    Marker Score: 376
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.59
    Marker Score: 5,802
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.58
    Marker Score: 242
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.55
    Marker Score: 391
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.55
    Marker Score: 448
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.54
    Marker Score: 510
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.54
    Marker Score: 1,397
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.54
    Marker Score: 505
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.53
    Marker Score: 267
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.53
    Marker Score: 1,549
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.52
    Marker Score: 2,176
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.52
    Marker Score: 296
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.52
    Marker Score: 503
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.5
    Marker Score: 173
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.5
    Marker Score: 1,235
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.49
    Marker Score: 969
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.48
    Marker Score: 332
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.47
    Marker Score: 418
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.46
    Marker Score: 816
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.45
    Marker Score: 378
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.45
    Marker Score: 769
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.45
    Marker Score: 396
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.44
    Marker Score: 112
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.44
    Marker Score: 300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.44
    Marker Score: 472
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.43
    Marker Score: 564
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.43
    Marker Score: 259
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.41
    Marker Score: 449
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.41
    Marker Score: 225
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.41
    Marker Score: 425
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.4
    Marker Score: 525
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 822
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 761
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.4
    Marker Score: 172
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.39
    Marker Score: 137
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.38
    Marker Score: 229
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.36
    Marker Score: 310
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.36
    Marker Score: 167

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PIK3R5 is a regulatory subunit of the PI3K complex, which is composed of three subunits: p110α, p110β, and p110γ. PIK3R5 binds to these subunits and regulates their activity, influencing the overall PI3K signaling pathway. The protein is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. PIK3R5 has been shown to modulate the activity of PI3K complexes in response to various stimuli, including growth factors, cytokines, and lipids. **Pathways and Functions:** PIK3R5 is involved in several signaling pathways, including: 1. **G-protein coupled receptor (GPCR) signaling:** PIK3R5 regulates the activity of PI3K complexes in response to GPCR activation, leading to downstream signaling events, such as cell proliferation and differentiation. 2. **Immune response:** PIK3R5 plays a crucial role in regulating immune cell function, including macrophage and T cell activation, and cytokine production. 3. **Cell metabolism:** PIK3R5 modulates glucose and lipid metabolism by regulating the activity of PI3K complexes, which are involved in insulin signaling and lipid synthesis. 4. **Erythropoiesis:** PIK3R5 is required for the regulation of erythropoiesis, the process of red blood cell production, by modulating the activity of PI3K complexes in response to erythropoietin stimulation. **Clinical Significance:** Dysregulation of PIK3R5 has been implicated in several diseases, including: 1. **Cancer:** PIK3R5 mutations have been identified in various types of cancer, including breast, lung, and colon cancer, where they contribute to tumorigenesis and cancer progression. 2. **Autoimmune diseases:** PIK3R5 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it regulates immune cell function and cytokine production. 3. **Metabolic disorders:** PIK3R5 dysregulation has been linked to metabolic disorders, including insulin resistance and type 2 diabetes, where it modulates glucose and lipid metabolism. In conclusion, PIK3R5 is a critical regulator of PI3K complexes, which play a pivotal role in immune response, cell metabolism, and signaling pathways. Dysregulation of PIK3R5 has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 4066238587

Symbol: PI3R5_HUMAN

Name: Phosphoinositide 3-kinase regulatory subunit 5

UniProtKB Accession Codes:

Q8WYR1 B0LPH4 D3DTS3 Q5G936 Q5G938 Q5G939 Q8IZ23 Q9Y2Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 6 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15797027

Title: p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.

PubMed ID: 15797027

DOI: 10.1016/j.cub.2005.02.020

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22065524

Title: A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia.

PubMed ID: 22065524

DOI: 10.1002/humu.21650

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 880
  • Mass: 97348
  • Checksum: 70E356773B148A8A
  • Sequence:
    • MQPGATTCTE DRIQHALERC LHGLSLSRRS TSWSAGLCLN CWSLQELVSR DPGHFLILLE 
QILQKTREVQ EKGTYDLLTP LALLFYSTVL CTPHFPPDSD LLLKAASTYH RFLTWPVPYC 
SICQELLTFI DAELKAPGIS YQRLVRAEQG LPIRSHRSST VTVLLLNPVE VQAEFLAVAN 
KLSTPGHSPH SAYTTLLLHA FQATFGAHCD VPGLHCRLQA KTLAELEDIF TETAEAQELA 
SGIGDAAEAR RWLRTKLQAV GEKAGFPGVL DTAKPGKLHT IPIPVARCYT YSWSQDSFDI 
LQEILLKEQE LLQPGILGDD EEEEEEEEEV EEDLETDGHC AERDSLLSTS SLASHDSTLS 
LASSQASGPA LSRHLLTSFV SGLSDGMDSG YVEDSEESSS EWPWRRGSQE RRGHRRPGQK 
FIRIYKLFKS TSQLVLRRDS RSLEGSSDTA LPLRRAGSLC SPLDEPVSPP SRAQRSRSLP 
QPKLGTQLPS WLLAPASRPQ RRRPFLSGDE DPKASTLRVV VFGSDRISGK VARAYSNLRR 
LENNRPLLTR FFKLQFFYVP VKRSHGTSPG ACPPPRSQTP SPPTDSPRHA SPGELGTTPW 
EESTNDISHY LGMLDPWYER NVLGLMHLPP EVLCQQSLKA EAQALEGSPT QLPILADMLL 
YYCRFAARPV LLQVYQTELT FITGEKTTEI FIHSLELGHS AATRAIKASG PGSKRLGIDG 
DREAVPLTLQ IIYSKGAISG RSRWSNLEKV CTSVNLNKAC RKQEELDSSM EALTLNLTEV 
VKRQNSKSKK GFNQISTSQI KVDKVQIIGS NSCPFAVCLD QDERKILQSV VRCEVSPCYK 
PEKSDLSSPP QTPPDLPAQA APDLCSLLCL PIMTFSGALP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.