Details for: TNPO3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.79
Marker Score: 1,973 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.63
Marker Score: 100,230 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.6
Marker Score: 31,904 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.6
Marker Score: 15,217 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.57
Marker Score: 58,028 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.55
Marker Score: 14,595 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.54
Marker Score: 15,874 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.53
Marker Score: 13,135 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.51
Marker Score: 57,410 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.51
Marker Score: 22,554 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.5
Marker Score: 32,107 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.49
Marker Score: 1,291 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.49
Marker Score: 26,424 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.46
Marker Score: 5,656 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.45
Marker Score: 6,004 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.38
Marker Score: 2,129 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.36
Marker Score: 10,416 - Cell Name: neuron (CL0000540)
Fold Change: 1.35
Marker Score: 5,485 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.32
Marker Score: 552 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.31
Marker Score: 2,877 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.29
Marker Score: 1,466 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.25
Marker Score: 1,350 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.23
Marker Score: 1,420 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.23
Marker Score: 1,657 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.22
Marker Score: 41,093 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.22
Marker Score: 937 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.21
Marker Score: 5,072 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.21
Marker Score: 354 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.16
Marker Score: 2,230 - Cell Name: podocyte (CL0000653)
Fold Change: 1.15
Marker Score: 426 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.09
Marker Score: 5,065 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.09
Marker Score: 651 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.06
Marker Score: 1,276 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.04
Marker Score: 549 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.04
Marker Score: 833 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.04
Marker Score: 283 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.03
Marker Score: 6,644 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.02
Marker Score: 593 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.02
Marker Score: 689 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.01
Marker Score: 499 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.01
Marker Score: 490 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1
Marker Score: 697 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1
Marker Score: 339 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,646 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,872 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.99
Marker Score: 370 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.98
Marker Score: 1,036 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.98
Marker Score: 551 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,384 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.98
Marker Score: 4,227 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.98
Marker Score: 282 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.96
Marker Score: 304 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.96
Marker Score: 15,344 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.95
Marker Score: 1,150 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.95
Marker Score: 241 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.94
Marker Score: 835 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,391 - Cell Name: fat cell (CL0000136)
Fold Change: 0.94
Marker Score: 524 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.93
Marker Score: 1,899 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.93
Marker Score: 1,159 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 478 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.93
Marker Score: 14,475 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.91
Marker Score: 1,295 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.91
Marker Score: 453 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.91
Marker Score: 1,322 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.9
Marker Score: 1,468 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9
Marker Score: 1,332 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,694 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5,095 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.88
Marker Score: 357 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.88
Marker Score: 762 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.87
Marker Score: 924 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.87
Marker Score: 2,082 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.87
Marker Score: 799 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.87
Marker Score: 508 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.87
Marker Score: 315 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.87
Marker Score: 934 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.85
Marker Score: 4,478 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.85
Marker Score: 856 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.85
Marker Score: 2,302 - Cell Name: neural crest cell (CL0011012)
Fold Change: 0.84
Marker Score: 903 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.84
Marker Score: 4,540 - Cell Name: basal cell (CL0000646)
Fold Change: 0.84
Marker Score: 1,089 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.83
Marker Score: 2,056 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.82
Marker Score: 316 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.82
Marker Score: 1,431 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.82
Marker Score: 866 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.82
Marker Score: 1,922 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.81
Marker Score: 18,132 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.81
Marker Score: 293 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.81
Marker Score: 163 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 323 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8
Marker Score: 1,834 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.8
Marker Score: 2,759 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.8
Marker Score: 278 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8
Marker Score: 191 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.8
Marker Score: 759
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3919634247
Symbol: TNPO3_HUMAN
Name: Importin-12
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10366588
Title: Transportin-SR, a nuclear import receptor for SR proteins.
PubMed ID: 10366588
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10713112
Title: A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins.
PubMed ID: 10713112
PubMed ID: 11517331
Title: Transportin-SR2 mediates nuclear import of phosphorylated SR proteins.
PubMed ID: 11517331
PubMed ID: 12628928
Title: A novel splicing regulator shares a nuclear import pathway with SR proteins.
PubMed ID: 12628928
DOI: 10.1093/emboj/cdg126
PubMed ID: 18722123
Title: Transportin-SR2 imports HIV into the nucleus.
PubMed ID: 18722123
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21901095
Title: Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.
PubMed ID: 21901095
PubMed ID: 22398280
Title: TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.
PubMed ID: 22398280
DOI: 10.1128/jvi.00451-12
PubMed ID: 23878195
Title: Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.
PubMed ID: 23878195
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23667635
Title: Next-generation sequencing identifies transportin 3 as the causative gene for LGMD1F.
PubMed ID: 23667635
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28356354
Title: N-terminal half of transportin SR2 interacts with HIV integrase.
PubMed ID: 28356354
PubMed ID: 29329553
Title: Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.
PubMed ID: 29329553
PubMed ID: 31465518
Title: The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection.
PubMed ID: 31465518
PubMed ID: 24915079
Title: Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.
PubMed ID: 24915079
PubMed ID: 24449914
Title: Structural basis for nuclear import of splicing factors by human Transportin 3.
PubMed ID: 24449914
PubMed ID: 30916345
Title: Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
PubMed ID: 30916345
DOI: 10.1093/nar/gkz206
PubMed ID: 23543484
Title: Limb-girdle muscular dystrophy 1F is caused by a microdeletion in the transportin 3 gene.
PubMed ID: 23543484
DOI: 10.1093/brain/awt074
PubMed ID: 31071488
Title: A novel pathogenic variant in TNPO3 in a Hungarian family with limb-girdle muscular dystrophy 1F.
PubMed ID: 31071488
PubMed ID: 31192305
Title: Novel mutation in TNPO3 causes congenital limb-girdle myopathy with slow progression.
PubMed ID: 31192305
Sequence Information:
- Length: 923
- Mass: 104203
- Checksum: CF7CDC14CDBA56AB
- Sequence:
MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPENNPTLV EVLEGVVRLP ETVHTAVRYT SIELVGEMSE VVDRNPQFLD PVLGYLMKGL CEKPLASAAA KAIHNICSVC RDHMAQHFNG LLEIARSLDS FLLSPEAAVG LLKGTALVLA RLPLDKITEC LSELCSVQVM ALKKLLSQEP SNGISSDPTV FLDRLAVIFR HTNPIVENGQ THPCQKVIQE IWPVLSETLN KHRADNRIVE RCCRCLRFAV RCVGKGSAAL LQPLVTQMVN VYHVHQHSCF LYLGSILVDE YGMEEGCRQG LLDMLQALCI PTFQLLEQQN GLQNHPDTVD DLFRLATRFI QRSPVTLLRS QVVIPILQWA IASTTLDHRD ANCSVMRFLR DLIHTGVAND HEEDFELRKE LIGQVMNQLG QQLVSQLLHT CCFCLPPYTL PDVAEVLWEI MQVDRPTFCR WLENSLKGLP KETTVGAVTV THKQLTDFHK QVTSAEECKQ VCWALRDFTR LFR
Genular Protein ID: 3502713196
Symbol: B3KMX1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 480
- Mass: 53946
- Checksum: E1BD57FB9E48AE79
- Sequence:
MAAIAKSVDP ENNPTLVEVL EGVVRLPETV HTAVRYTSIE LVGEMSEVVD RNPQFLDPVL GYLMKGLCEK PLASAAAKAI HNICSVCRDH MAQHFNGLLE IARSLDSFLL SPEAAVGLLK GTALVLARLP LDKITECLSE LCSVQVMALK KLLSQEPSNG ISSDPTVFLD RLAVIFRHTN PIVENGQTHP CQKVIQEIWP VLSETLNKHR ADNRIVERCC RCLRFAVRCV GKGSAALLQP LVTQMVNVYH VHQHSCFLYL GSILVDEYGM EEGCRQGLLD MLQALCIPTF QLLEQQNGLQ NHPDTVDDLF RLATRFIQRS PVTLLRSQVV IPILQWAIAS TTLDHRDANC SVMRFLRDLI HTGVANDHEE DFELRKELIG QVMNQLGQQL VSQLLHTCCF CLPPYTLPDV AEVLWEIMQV DRPTFCRWLE NSLKGLPKET TVGAVTVTHK QLTDFHKQVT SAEECKQVCW ALRDFTRLFR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.