Details for: ADAT1

Gene ID: 23536

Symbol: ADAT1

Ensembl ID: ENSG00000065457

Description: adenosine deaminase tRNA specific 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.04
    Marker Score: 1,818
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,749
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,974
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,716
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 601
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,988
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,253
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13,194
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1,194
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,243
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,992
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 282
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.67
    Marker Score: 41,104
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1,322
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3,855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.64
    Marker Score: 5,481
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.63
    Marker Score: 5,999
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.62
    Marker Score: 1,746
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.56
    Marker Score: 831
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 373
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.56
    Marker Score: 5,772
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.56
    Marker Score: 20,614
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.54
    Marker Score: 540
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.52
    Marker Score: 162
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 326
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.51
    Marker Score: 635
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5
    Marker Score: 531
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.5
    Marker Score: 4,677
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.5
    Marker Score: 18,850
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.47
    Marker Score: 465
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.47
    Marker Score: 1,822
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 151
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.46
    Marker Score: 1,567
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.45
    Marker Score: 1,071
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3,826
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.43
    Marker Score: 525
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.43
    Marker Score: 445
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.43
    Marker Score: 8,508
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.43
    Marker Score: 3,275
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.42
    Marker Score: 442
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.41
    Marker Score: 1,124
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.41
    Marker Score: 92
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.41
    Marker Score: 6,141
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.4
    Marker Score: 1,672
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.4
    Marker Score: 576
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.39
    Marker Score: 86
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.39
    Marker Score: 88
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.39
    Marker Score: 886
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.39
    Marker Score: 955
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.39
    Marker Score: 1,524
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.39
    Marker Score: 428
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.39
    Marker Score: 241
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.38
    Marker Score: 257
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 183
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.38
    Marker Score: 83
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.38
    Marker Score: 258
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.38
    Marker Score: 93
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.38
    Marker Score: 90
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 597
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.37
    Marker Score: 191
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.37
    Marker Score: 154
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.37
    Marker Score: 410
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.36
    Marker Score: 341
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.36
    Marker Score: 86
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.36
    Marker Score: 391
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.36
    Marker Score: 101
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 322
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.36
    Marker Score: 78
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.36
    Marker Score: 386
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.36
    Marker Score: 112
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.36
    Marker Score: 89
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.35
    Marker Score: 89
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 154
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.35
    Marker Score: 174
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.35
    Marker Score: 101
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.35
    Marker Score: 669
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 249
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.35
    Marker Score: 149
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 652

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAT1 is a member of the ADAR (adenosine deaminases acting on RNA) family of enzymes, which are known for their ability to modify RNA molecules through deamination reactions. The ADAT1 protein exhibits high specificity for tRNAs, with a preference for adenosine-37 (A37) residues. This specificity is crucial for maintaining tRNA function and preventing aberrant RNA processing. ADAT1 is predominantly expressed in germ cells, neurons, and certain epithelial cells, suggesting its involvement in cellular differentiation and development. **Pathways and Functions:** ADAT1 is involved in several key pathways, including: 1. **RNA metabolism:** ADAT1 plays a crucial role in the modification and processing of tRNAs, which are essential for protein synthesis and cellular function. 2. **Metal ion binding:** ADAT1 exhibits metal ion-binding activity, which is necessary for its enzymatic function. 3. **RNA binding:** ADAT1 interacts with various RNA molecules, including tRNAs, to regulate their processing and function. 4. **Trna modification in the nucleus and cytosol:** ADAT1 is responsible for modifying tRNAs in both the nucleus and cytosol, highlighting its role in regulating tRNA function in different cellular compartments. **Clinical Significance:** ADAT1 has been implicated in various disease states, including: 1. **Neurological disorders:** Mutations in ADAT1 have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** ADAT1 expression is altered in various types of cancer, including colorectal and breast cancer. 3. **Immune system disorders:** ADAT1 is involved in the regulation of immune cell function, and alterations in ADAT1 expression have been observed in autoimmune diseases, such as multiple sclerosis. In conclusion, ADAT1 plays a critical role in regulating RNA metabolism, cellular differentiation, and immune function. Further research is necessary to fully elucidate the mechanisms by which ADAT1 contributes to disease pathology and to explore its potential as a therapeutic target for various disease states. **References:** [Insert references to relevant studies and literature articles] Note: This article is a summary of the gene ADAT1 and its characteristics, pathways, and functions, as an expert immunologist would write. The references section is not included in this response but would typically include relevant studies and literature articles to support the information presented.

Genular Protein ID: 4264632951

Symbol: ADAT1_HUMAN

Name: tRNA-specific adenosine deaminase 1

UniProtKB Accession Codes:

Q9BUB4 Q9NVB7 Q9UNG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 15 DMDM 1 DNASU 1 EC 2 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10430867

Title: Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes.

PubMed ID: 10430867

DOI: 10.1073/pnas.96.16.8895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 502
  • Mass: 55392
  • Checksum: 3664E4C50DA9DFE0
  • Sequence:
    • MWTADEIAQL CYEHYGIRLP KKGKPEPNHE WTLLAAVVKI QSPADKACDT PDKPVQVTKE 
VVSMGTGTKC IGQSKMRKNG DILNDSHAEV IARRSFQRYL LHQLQLAATL KEDSIFVPGT 
QKGVWKLRRD LIFVFFSSHT PCGDASIIPM LEFEDQPCCP VFRNWAHNSS VEASSNLEAP 
GNERKCEDPD SPVTKKMRLE PGTAAREVTN GAAHHQSFGK QKSGPISPGI HSCDLTVEGL 
ATVTRIAPGS AKVIDVYRTG AKCVPGEAGD SGKPGAAFHQ VGLLRVKPGR GDRTRSMSCS 
DKMARWNVLG CQGALLMHLL EEPIYLSAVV IGKCPYSQEA MQRALIGRCQ NVSALPKGFG 
VQELKILQSD LLFEQSRSAV QAKRADSPGR LVPCGAAISW SAVPEQPLDV TANGFPQGTT 
KKTIGSLQAR SQISKVELFR SFQKLLSRIA RDKWPHSLRV QKLDTYQEYK EAASSYQEAW 
STLRKQVFGS WIRNPPDYHQ FK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.