Details for: OR52A1

Gene ID: 23538

Symbol: OR52A1

Ensembl ID: ENSG00000182070

Description: olfactory receptor family 52 subfamily A member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,177
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.05
    Marker Score: 1,173
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.63
    Marker Score: 1,868
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.5
    Marker Score: 805
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 799
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 802
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.36
    Marker Score: 103
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.34
    Marker Score: 1,086
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 351
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 533
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 145
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.22
    Marker Score: 1,850
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3,187
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.12
    Marker Score: 312
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.11
    Marker Score: 95
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.09
    Marker Score: 146
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 156
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.08
    Marker Score: 132
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.07
    Marker Score: 285
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 46
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 139
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.06
    Marker Score: 111
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 134
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.05
    Marker Score: 2,781
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.05
    Marker Score: 2,922
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.05
    Marker Score: 73
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.05
    Marker Score: 3,041
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.04
    Marker Score: 129
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family 52 Subfamily A Member 1**: OR52A1 is a member of the olfactory receptor family 52 subfamily, which is a group of genes that encode for olfactory receptors responsible for detecting odorant molecules in the air. 2. **Significantly Expressed Cells**: OR52A1 is expressed in various cell types, including goblet cells, intestinal crypt stem cells, transit amplifying cells, and plasma cells, highlighting its widespread presence in the human body. 3. **Plasma Membrane Localization**: OR52A1 is localized on the plasma membrane, where it can interact with odorant molecules and trigger a signaling cascade to initiate sensory perception. 4. **G Protein-Coupled Receptor Activity**: OR52A1 is a G protein-coupled receptor (GPCR) that activates G proteins, leading to the activation of downstream signaling pathways. **Pathways and Functions:** 1. **Detection of Chemical Stimulus**: OR52A1 plays a crucial role in detecting chemical stimuli involved in sensory perception of smell. When an odorant molecule binds to OR52A1, it activates a signaling cascade that triggers the perception of a specific smell. 2. **Expression and Translocation of Olfactory Receptors**: OR52A1 is involved in the expression and translocation of olfactory receptors on the plasma membrane. This process is essential for the detection of odorant molecules and the initiation of sensory perception. 3. **Signal Transduction**: OR52A1 activates G proteins, leading to the activation of downstream signaling pathways that regulate various cellular processes, including gene expression, cell proliferation, and differentiation. 4. **Transmembrane Signaling Receptor Activity**: OR52A1 is a transmembrane signaling receptor that interacts with odorant molecules and triggers a signaling cascade to initiate sensory perception. **Clinical Significance:** 1. **Olfactory Disorders**: OR52A1 dysfunction has been implicated in various olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Cancer Research**: OR52A1 is overexpressed in certain types of cancer, including colorectal cancer, suggesting its potential role as a biomarker for cancer diagnosis and treatment. 3. **Neurological Disorders**: OR52A1 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its potential role in the pathogenesis of these conditions. 4. **Personalized Medicine**: Understanding the function and regulation of OR52A1 can lead to the development of personalized medicine approaches for treating olfactory disorders and other diseases. In conclusion, OR52A1 is a critical olfactory receptor that plays a significant role in the detection of chemical stimuli involved in sensory perception of smell. Its widespread expression in various cell types and involvement in signal transduction and transmembrane signaling receptor activity underscore its importance in maintaining our sense of smell. Further research on OR52A1 can lead to the development of novel therapeutic approaches for treating olfactory disorders and other diseases.

Genular Protein ID: 686515839

Symbol: O52A1_HUMAN

Name: Olfactory receptor 52A1

UniProtKB Accession Codes:

Q9UKL2 Q6IF31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10512676

Title: An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells.

PubMed ID: 10512676

DOI: 10.1006/geno.1999.5935

PubMed ID: 11121057

Title: Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.

PubMed ID: 11121057

DOI: 10.1073/pnas.97.26.14560

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 35322
  • Checksum: B05AFD46352D513C
  • Sequence:
    • MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI IKSERSLHEP 
LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL LQMWFIHTLQ GIESGILVAM 
ALDRYVAICY PLRHANIFTH QLVIQIGTMV VLRAAILVAP CLVLIKCRFQ FYHTTVISHS 
YCEHMAIVKL AAANVQVNKI YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA 
FNTCIAHICV FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT 
QIRIHVVKMF CS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.