Genular: Defining Cellular Identity and Function

Details for: SLC16A8

Gene ID: 23539

Symbol: SLC16A8

Ensembl ID: ENSG00000100156

Description: solute carrier family 16 member 8

Associated with

Basigin interactions
(R-HSA-210991)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Metabolism
(R-HSA-1430728)
Proton-coupled monocarboxylate transport
(R-HSA-433692)
Pyruvate metabolism
(R-HSA-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-HSA-71406)
Slc-mediated transmembrane transport
(R-HSA-425407)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-HSA-425366)
Transport of small molecules
(R-HSA-382551)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Lactate transmembrane transport
(GO:0035873)
Lactate transmembrane transporter activity
(GO:0015129)
Lactate transport
(GO:0015727)
Membrane
(GO:0016020)
Monocarboxylic acid transmembrane transporter activity
(GO:0008028)
Monocarboxylic acid transport
(GO:0015718)
Plasma membrane
(GO:0005886)
Symporter activity
(GO:0015293)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.55
Marker Score: 30,049
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1,998
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,172
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,820
Cell Name: germ cell (CL0000586)
Fold Change: 1.1
Marker Score: 1,927
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,833
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,058
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.94
Marker Score: 638
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,353
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.9
Marker Score: 374
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,289
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.83
Marker Score: 383
Cell Name: male germ cell (CL0000015)
Fold Change: 0.79
Marker Score: 228
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 580
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.68
Marker Score: 977
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.55
Marker Score: 353
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.51
Marker Score: 1,065
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 473
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.45
Marker Score: 132
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.43
Marker Score: 284
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.43
Marker Score: 537
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.39
Marker Score: 738
Cell Name: plasma cell (CL0000786)
Fold Change: 0.38
Marker Score: 422
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.37
Marker Score: 5,774
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.36
Marker Score: 520
Cell Name: goblet cell (CL0000160)
Fold Change: 0.35
Marker Score: 2,337
Cell Name: mast cell (CL0000097)
Fold Change: 0.34
Marker Score: 198
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.33
Marker Score: 666
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.27
Marker Score: 129
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.24
Marker Score: 75
Cell Name: oocyte (CL0000023)
Fold Change: 0.23
Marker Score: 57
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.23
Marker Score: 89
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.23
Marker Score: 101
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.22
Marker Score: 527
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.22
Marker Score: 150
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.19
Marker Score: 2,000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.17
Marker Score: 103
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 41
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.16
Marker Score: 55
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.15
Marker Score: 117
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.15
Marker Score: 39
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.15
Marker Score: 39
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.14
Marker Score: 132
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.14
Marker Score: 404
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.14
Marker Score: 59
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.14
Marker Score: 158
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.14
Marker Score: 911
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.14
Marker Score: 83
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.13
Marker Score: 71
Cell Name: osteoblast (CL0000062)
Fold Change: 0.13
Marker Score: 71
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.13
Marker Score: 1,326
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.13
Marker Score: 208
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.12
Marker Score: 93
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.12
Marker Score: 288
Cell Name: neuron (CL0000540)
Fold Change: 0.12
Marker Score: 478
Cell Name: B cell (CL0000236)
Fold Change: 0.12
Marker Score: 111
Cell Name: basal cell (CL0000646)
Fold Change: 0.12
Marker Score: 150
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.12
Marker Score: 66
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.12
Marker Score: 82
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.11
Marker Score: 113
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.11
Marker Score: 38
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.11
Marker Score: 35
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.11
Marker Score: 45
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.11
Marker Score: 30
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1
Marker Score: 47
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.1
Marker Score: 58
Cell Name: keratocyte (CL0002363)
Fold Change: 0.1
Marker Score: 23
Cell Name: neural cell (CL0002319)
Fold Change: 0.1
Marker Score: 47
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.1
Marker Score: 149
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.1
Marker Score: 35
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.09
Marker Score: 156
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.09
Marker Score: 29
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.09
Marker Score: 86
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.09
Marker Score: 31
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.09
Marker Score: 52
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.09
Marker Score: 2,974
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.08
Marker Score: 80
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.08
Marker Score: 53
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.08
Marker Score: 27
Cell Name: astrocyte (CL0000127)
Fold Change: 0.08
Marker Score: 65
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.07
Marker Score: 67
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.07
Marker Score: 175
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.07
Marker Score: 15
Cell Name: reticular cell (CL0000432)
Fold Change: 0.07
Marker Score: 27
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.07
Marker Score: 104

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Gene Structure:** The SLC16A8 gene is located on chromosome 10q24.3 and consists of 8 exons that encode a 453-amino acid protein. 2. **Protein Function:** MOT3 is a type of facilitated diffusion transporter that uses energy from the proton gradient to transport monocarboxylates across cell membranes. 3. **Expression Patterns:** The SLC16A8 gene is highly expressed in the retina, enterocytes, and cerebral cortex, suggesting its involvement in neuronal function and metabolism. 4. **Cellular Localization:** MOT3 is primarily localized to the basolateral plasma membrane, where it regulates the transport of lactate and pyruvate. **Pathways and Functions:** 1. **Metabolic Pathways:** MOT3 is involved in the transport of lactate and pyruvate, which are crucial for energy metabolism in the brain, retina, and other tissues. 2. **Neurotransmitter Regulation:** The SLC16A8 gene is also implicated in the regulation of GABAergic neurotransmission, which is essential for neuronal function and synaptic plasticity. 3. **Waste Removal:** MOT3 plays a role in the transport of toxic substances, such as lactate, out of cells, which helps maintain cellular homeostasis. 4. **Cell Signaling:** The SLC16A8 gene is involved in cell signaling pathways, including those regulating cell growth, differentiation, and survival. **Clinical Significance:** 1. **Metabolic Disorders:** Mutations in the SLC16A8 gene have been associated with metabolic disorders, such as lactate dehydrogenase deficiency, which can lead to neurological symptoms and developmental delays. 2. **Neurological Disorders:** The SLC16A8 gene has been implicated in the pathogenesis of neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. 3. **Cancer:** MOT3 has been found to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 4. **Neuroprotection:** The SLC16A8 gene may play a role in neuroprotection, as MOT3 has been shown to reduce oxidative stress and inflammation in neuronal cells. In conclusion, the SLC16A8 gene is a critical regulator of monocarboxylate transport, which has significant implications for human health and disease. Further research is needed to fully elucidate the functions and clinical significance of this gene, but the current evidence suggests that it plays a vital role in maintaining cellular homeostasis, regulating neurotransmission, and preventing metabolic disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Monocarboxylate transporter 3

Genular Protein ID: 2456584493

Symbol: MOT3_HUMAN

Name: Monocarboxylate transporter 3

UniProtKB Accession Codes:

O95907 Q9UBE2

Database IDs:

Citations:

PubMed ID: 10493836

Title: Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2.

PubMed ID: 10493836

DOI: 10.1006/geno.1999.5926

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 21199217

Title: Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia.

PubMed ID: 21199217

DOI: 10.1111/j.1600-0854.2010.01155.x

Sequence Information:

Length: 504
Mass: 52319
Checksum: E924D4FC31340398
Sequence:

MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF DAGYSDTAWV 
SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI LASFATRLLE LYLTAGVLTG 
LGLALNFQPS LIMLGLYFER RRPLANGLAA AGSPVFLSAL SPLGQQLLER FGWRGGFLLL 
GGLLLHCCAC GAVMRPPPGP GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR 
RLLDLAVCTD RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI 
VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC VAFGLSYGMV 
GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG RLVDVLKNYE IIFYLAGSEV 
ALAGVFMAVA TNCCLRCAKA APSGPGTEGG ASDTEDAEAE GDSEPLPVVA EEPGNLEALE 
VLSARGEPTE PEIEARPRLA AESV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.