Details for: SEC14L2

Gene ID: 23541

Symbol: SEC14L2

Ensembl ID: ENSG00000100003

Description: SEC14 like lipid binding 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.67
    Marker Score: 2,580
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.58
    Marker Score: 33,736
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.48
    Marker Score: 2,050
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,240
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2,790
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1
    Marker Score: 4,243
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.07
    Marker Score: 318
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 778
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1,922
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,022
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1
    Marker Score: 417
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 630
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14,610
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.91
    Marker Score: 1,841
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,137
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.85
    Marker Score: 2,412
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.84
    Marker Score: 5,383
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.83
    Marker Score: 1,277
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.81
    Marker Score: 1,433
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48,656
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.75
    Marker Score: 566
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.75
    Marker Score: 267
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.74
    Marker Score: 1,850
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.73
    Marker Score: 3,139
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 436
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.72
    Marker Score: 197
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.71
    Marker Score: 982
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 640
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7
    Marker Score: 219
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4,198
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,883
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.66
    Marker Score: 387
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.66
    Marker Score: 6,242
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.65
    Marker Score: 784
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 555
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.63
    Marker Score: 5,443
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.63
    Marker Score: 3,381
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.63
    Marker Score: 23,131
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.62
    Marker Score: 199
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.61
    Marker Score: 2,354
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.57
    Marker Score: 2,805
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 270
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.56
    Marker Score: 510
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.55
    Marker Score: 377
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.54
    Marker Score: 731
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 342
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.49
    Marker Score: 1,190
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.47
    Marker Score: 2,269
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.46
    Marker Score: 3,952
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 203
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.43
    Marker Score: 1,765
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16,085
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.42
    Marker Score: 1,718
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.42
    Marker Score: 282
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.42
    Marker Score: 283
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 106
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.41
    Marker Score: 1,700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.41
    Marker Score: 8,062
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.4
    Marker Score: 122
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4
    Marker Score: 433
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.4
    Marker Score: 223
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.39
    Marker Score: 452
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.39
    Marker Score: 883
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.38
    Marker Score: 112
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.38
    Marker Score: 1,465
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.36
    Marker Score: 228
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.36
    Marker Score: 210
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.36
    Marker Score: 850
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.35
    Marker Score: 257
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.35
    Marker Score: 5,285
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 239
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.35
    Marker Score: 2,747
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.35
    Marker Score: 199
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.35
    Marker Score: 429
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.34
    Marker Score: 2,600
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.34
    Marker Score: 2,517
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.34
    Marker Score: 3,177
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.34
    Marker Score: 281
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.33
    Marker Score: 1,376
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.33
    Marker Score: 356
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.32
    Marker Score: 121
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.31
    Marker Score: 176

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SEC14L2 is a member of the SEC14 family, which is characterized by its ability to bind to phospholipids and regulate cellular processes. The protein exhibits high affinity for phospholipids and cholesterol, allowing it to interact with other proteins and lipids to regulate cellular functions. SEC14L2 is a cytosolic protein, with no known transmembrane domains, suggesting its role in regulating intracellular processes. **Pathways and Functions:** SEC14L2 is involved in several cellular pathways, including: 1. **Cholesterol biosynthesis regulation**: SEC14L2 regulates the cholesterol biosynthetic pathway by interacting with enzymes involved in cholesterol synthesis, such as HMG-CoA reductase. 2. **Transcriptional activation**: SEC14L2 acts as a positive regulator of DNA-templated transcription, promoting the activation of gene expression. 3. **Phospholipid binding**: SEC14L2 binds to phospholipids, regulating their distribution and organization within the cell membrane. 4. **Exosome regulation**: SEC14L2 is involved in the regulation of exosome formation and function, which is crucial for cellular communication and waste removal. **Clinical Significance:** Dysregulation of SEC14L2 has been implicated in various diseases, including: 1. **Atherosclerosis**: SEC14L2 has been shown to regulate cholesterol biosynthesis, and its dysregulation may contribute to the development of atherosclerosis. 2. **Neurodegenerative diseases**: SEC14L2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysregulation may contribute to the accumulation of lipids and cholesterol. 3. **Cancer**: SEC14L2 has been shown to regulate cellular differentiation and proliferation, making it a potential target for cancer therapy. In conclusion, SEC14L2 is a critical gene involved in regulating cholesterol biosynthesis, transcriptional activation, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 467094180

Symbol: S14L2_HUMAN

Name: SEC14-like protein 2

UniProtKB Accession Codes:

O76054 B7Z8Q1 F5H3U4 Q53EQ2 Q6PD61 Q9ULN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10829015

Title: A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization.

PubMed ID: 10829015

DOI: 10.1074/jbc.m000851200

PubMed ID: 11444841

Title: Tocopherol-associated protein is a ligand-dependent transcriptional activator.

PubMed ID: 11444841

DOI: 10.1006/bbrc.2001.5162

PubMed ID: 11226224

Title: Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis.

PubMed ID: 11226224

DOI: 10.1073/pnas.041620398

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12429094

Title: Crystal structure of the human supernatant protein factor.

PubMed ID: 12429094

DOI: 10.1016/s0969-2126(02)00884-5

Sequence Information:

  • Length: 403
  • Mass: 46145
  • Checksum: D846747EC8D1513E
  • Sequence:
    • MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ KSEAMLRKHV 
EFRKQKDIDN IISWQPPEVI QQYLSGGMCG YDLDGCPVWY DIIGPLDAKG LLFSASKQDL 
LRTKMRECEL LLQECAHQTT KLGRKVETIT IIYDCEGLGL KHLWKPAVEA YGEFLCMFEE 
NYPETLKRLF VVKAPKLFPV AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQVPVE 
YGGTMTDPDG NPKCKSKINY GGDIPRKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 
CVLRWQFMSD GADVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHLVPED GTLTCSDPGI 
YVLRFDNTYS FIHAKKVNFT VEVLLPDKAS EEKMKQLGAG TPK

Genular Protein ID: 4279549167

Symbol: B7Z3Z8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3Z8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 349
  • Mass: 39917
  • Checksum: DD6386A6E0BDBF05
  • Sequence:
    • MLRKHVEFRK QKDIDNIISW QPPEVIQQYL SGGMCGYDLD GCPVWYDIIG PLDAKGLLFS 
ASKQDLLRTK MRECELLLQE CAHQTTKLGR KVETITIIYD CEGLGLKHLW KPAVEAYGEF 
LCMFEENYPE TLKRLFVVKA PKLFPVAYNL IKPFLSEDTR KKIMVLGANW KEVLLKHISP 
DQVPVEYGGT MTDPDGNPKC KSKINYGGDI PRKYYVRDQV KQQYEHSVQI SRGSSHQVEY 
EILFPGCVLR WQFMSDGADV GFGIFLKTKM GERQRAGEMT EVLPNQRYNS HLVPEDGTLT 
CSDPGIYVLR FDNTYSFIHA KKVNFTVEVL LPDKASEEKM KQLGAGTPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.