Details for: MAPK8IP2

Gene ID: 23542

Symbol: MAPK8IP2

Ensembl ID: ENSG00000008735

Description: mitogen-activated protein kinase 8 interacting protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.73
    Marker Score: 2,676
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,169
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.45
    Marker Score: 5,920
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.28
    Marker Score: 13,246
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.28
    Marker Score: 1,435
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1,904
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.23
    Marker Score: 5,685
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2
    Marker Score: 73,735
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10,258
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.16
    Marker Score: 11,052
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.15
    Marker Score: 10,811
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.1
    Marker Score: 1,548
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.02
    Marker Score: 38,548
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.96
    Marker Score: 35,446
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.96
    Marker Score: 3,697
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.94
    Marker Score: 316
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1,774
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,306
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.91
    Marker Score: 1,849
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13,467
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.89
    Marker Score: 17,797
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.89
    Marker Score: 3,694
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.87
    Marker Score: 197
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.87
    Marker Score: 6,659
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.82
    Marker Score: 3,459
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.82
    Marker Score: 1,702
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.82
    Marker Score: 356
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.8
    Marker Score: 297
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.75
    Marker Score: 25,235
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.71
    Marker Score: 366
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.7
    Marker Score: 3,694
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.61
    Marker Score: 247
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6
    Marker Score: 1,002
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.59
    Marker Score: 286
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.58
    Marker Score: 172
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.57
    Marker Score: 691
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.57
    Marker Score: 268
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.56
    Marker Score: 533
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 361
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.52
    Marker Score: 269
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1,042
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.51
    Marker Score: 301
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.5
    Marker Score: 1,672
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.49
    Marker Score: 2,610
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.48
    Marker Score: 277
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.47
    Marker Score: 309
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7,319
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.44
    Marker Score: 147
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.41
    Marker Score: 3,069
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.4
    Marker Score: 1,678
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 397
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.4
    Marker Score: 919
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.37
    Marker Score: 101
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.37
    Marker Score: 7,823
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.36
    Marker Score: 149
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.35
    Marker Score: 119
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1,331
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 804
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.34
    Marker Score: 129
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 151
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.32
    Marker Score: 727
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.32
    Marker Score: 904
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3
    Marker Score: 376
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.29
    Marker Score: 179
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.27
    Marker Score: 154
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 235
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 138
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.26
    Marker Score: 266
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.25
    Marker Score: 237
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.25
    Marker Score: 693
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.24
    Marker Score: 162
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.23
    Marker Score: 402
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAPK8IP2 is a scaffold protein that interacts with multiple signaling molecules, including JNK kinases, MAPKs, and kinesins. Its protein-protein interactions enable the assembly of complex signaling complexes, facilitating the regulation of various cellular processes. Notably, MAPK8IP2 is involved in the regulation of stress-activated signaling pathways, including the JNK cascade and MAPK pathways, which are critical for immune response and cellular survival. **Pathways and Functions:** MAPK8IP2 is involved in several key pathways, including: 1. **JNK cascade:** MAPK8IP2 interacts with JNK kinases to regulate the activation of JNK proteins, which play a crucial role in stress response, apoptosis, and inflammation. 2. **MAPK pathways:** MAPK8IP2 interacts with MAPKs to regulate the activation of these kinases, which are involved in various cellular processes, including cell proliferation, differentiation, and survival. 3. **Neuronal development and synaptic transmission:** MAPK8IP2 is involved in the regulation of dendrite morphogenesis, excitatory postsynaptic potential, and synaptic transmission, highlighting its significance in neuronal development and function. 4. **Immune response:** MAPK8IP2 interacts with immune-related proteins, such as kinesins and AMPA receptors, to regulate immune response and inflammation. **Clinical Significance:** Dysregulation of MAPK8IP2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Alterations in MAPK8IP2 expression and function have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in disease pathology. 2. **Immune disorders:** Dysregulation of MAPK8IP2 has been implicated in immune disorders, such as rheumatoid arthritis and lupus, suggesting its potential role in immune regulation and disease. 3. **Cancer:** MAPK8IP2 is involved in the regulation of stress-activated signaling pathways, which are critical for cancer cell survival and proliferation, highlighting its potential role in cancer development and progression. In conclusion, MAPK8IP2 is a multifunctional protein that plays a critical role in various cellular processes, including immune response, neuronal development, and synaptic transmission. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of immune and neurological disorders. Further research is needed to fully elucidate the complex functions of MAPK8IP2 and its role in disease pathology.

Genular Protein ID: 3598323260

Symbol: JIP2_HUMAN

Name: C-Jun-amino-terminal kinase-interacting protein 2

UniProtKB Accession Codes:

Q13387 Q96G62 Q99771 Q9NZ59 Q9UKQ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10490659

Title: The JIP group of mitogen-activated protein kinase scaffold proteins.

PubMed ID: 10490659

DOI: 10.1128/mcb.19.10.7245

PubMed ID: 10756100

Title: cDNA cloning and mapping of a novel islet-brain/JNK interacting protein.

PubMed ID: 10756100

DOI: 10.1006/geno.2000.6129

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 11378392

Title: Fibroblast growth factor homologous factors are intracellular signaling proteins.

PubMed ID: 11378392

DOI: 10.1016/s0960-9822(01)00232-9

Sequence Information:

  • Length: 824
  • Mass: 87975
  • Checksum: 7EFC8F3BC58E37BB
  • Sequence:
    • MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL 
SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE EEEGDGEGQE GGDPGSEAPA 
PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD SLNNNGGFDL VRPASWQETA LCSPAPEALR 
ELPGPLPATD TGPGGAQSPV RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR 
GGRRSSQELS SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA 
SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL LSNLVSRMIS 
EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA AGPGGVELVD METLCAPPPP 
APAAPRPGPA QPGPCLFLSN PTRDTITPLW AAPGRAARPG RACSAACSEE EDEEDDEEEE 
DAEDSAGSPG GRGTGPSAPR DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS 
GGEASEEEAG AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV 
NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG ERGVFPAFYA 
HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG ILCAAMQKIA TARKLTVHLR 
PPASCDLEIS LRGVKLSLSG GGPEFQRCSH FFQMKNISFC GCHPRNSCYF GFITKHPLLS 
RFACHVFVSQ ESMRPVAQSV GRAFLEYYQE HLAYACPTED IYLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.