Details for: RBFOX2

Gene ID: 23543

Symbol: RBFOX2

Ensembl ID: ENSG00000100320

Description: RNA binding fox-1 homolog 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.77
    Marker Score: 6,707
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.44
    Marker Score: 14,881
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.37
    Marker Score: 147,738
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.93
    Marker Score: 21,102
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.79
    Marker Score: 19,861
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.73
    Marker Score: 3,306
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.65
    Marker Score: 2,537
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.64
    Marker Score: 81,359
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.64
    Marker Score: 16,839
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.57
    Marker Score: 7,827
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.35
    Marker Score: 7,697
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.32
    Marker Score: 25,027
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.28
    Marker Score: 4,760
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.21
    Marker Score: 10,522
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.15
    Marker Score: 1,829
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.12
    Marker Score: 6,005
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.01
    Marker Score: 3,410
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.99
    Marker Score: 3,443
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.98
    Marker Score: 1,434
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.91
    Marker Score: 2,517
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.89
    Marker Score: 51,324
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.84
    Marker Score: 1,698
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.82
    Marker Score: 60,208
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.77
    Marker Score: 55,125
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.76
    Marker Score: 11,513
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.76
    Marker Score: 871
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.74
    Marker Score: 21,007
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.73
    Marker Score: 40,769
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.69
    Marker Score: 2,205
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.67
    Marker Score: 3,322
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.67
    Marker Score: 2,542
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.66
    Marker Score: 101,181
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.62
    Marker Score: 10,964
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.61
    Marker Score: 830
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.61
    Marker Score: 1,463
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.6
    Marker Score: 1,282
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.58
    Marker Score: 3,125
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.53
    Marker Score: 2,845
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.53
    Marker Score: 10,499
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.53
    Marker Score: 1,307
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.52
    Marker Score: 3,040
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.52
    Marker Score: 1,363
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.51
    Marker Score: 1,394
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.5
    Marker Score: 1,927
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.47
    Marker Score: 1,300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.47
    Marker Score: 721
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.45
    Marker Score: 1,026
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.43
    Marker Score: 6,945
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.41
    Marker Score: 3,245
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.41
    Marker Score: 2,270
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.41
    Marker Score: 4,888
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.39
    Marker Score: 1,395
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.39
    Marker Score: 88,122
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.34
    Marker Score: 2,829
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.33
    Marker Score: 604
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.33
    Marker Score: 670
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.31
    Marker Score: 37,106
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.31
    Marker Score: 887
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3
    Marker Score: 3,870
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.29
    Marker Score: 1,509
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.29
    Marker Score: 822
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.28
    Marker Score: 1,076
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.26
    Marker Score: 8,735
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.25
    Marker Score: 2,489
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.25
    Marker Score: 5,640
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.21
    Marker Score: 7,866
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.18
    Marker Score: 733
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20,250
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.15
    Marker Score: 5,151
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.15
    Marker Score: 1,202
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.12
    Marker Score: 4,989
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.1
    Marker Score: 536
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.1
    Marker Score: 1,248
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.1
    Marker Score: 1,596
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 2.09
    Marker Score: 925
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.07
    Marker Score: 2,554
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,746
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.05
    Marker Score: 27,061
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.98
    Marker Score: 2,325
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.98
    Marker Score: 20,462
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.97
    Marker Score: 652
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.96
    Marker Score: 7,994
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.96
    Marker Score: 2,108
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.93
    Marker Score: 12,529
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.93
    Marker Score: 1,126
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,146
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.87
    Marker Score: 1,620
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.87
    Marker Score: 510
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,933
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.85
    Marker Score: 1,220
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.83
    Marker Score: 2,280
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.82
    Marker Score: 690
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.81
    Marker Score: 1,213
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.77
    Marker Score: 643
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.76
    Marker Score: 1,853
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.75
    Marker Score: 1,232
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.73
    Marker Score: 556
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.73
    Marker Score: 6,410
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.73
    Marker Score: 542
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.71
    Marker Score: 1,076

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA binding ability:** RBFOX2 possesses a high affinity for RNA, allowing it to interact with various RNA molecules, including mRNAs, microRNAs, and non-coding RNAs. 2. **Alternative splicing regulation:** RBFOX2 modulates alternative splicing by interacting with spliceosomal proteins and influencing the assembly of the spliceosome complex. 3. **Transcriptional control:** RBFOX2 acts as a transcriptional corepressor, regulating the expression of target genes by interacting with transcription factors and chromatin-modifying enzymes. 4. **Cell proliferation and differentiation:** RBFOX2 influences cell proliferation and differentiation by regulating the expression of genes involved in these processes. 5. **Tissue-specific expression:** RBFOX2 is expressed in multiple cell types, including neuronal, epithelial, and cardiac cells, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** 1. **Intracellular estrogen receptor signaling pathway:** RBFOX2 interacts with estrogen receptor-alpha (ERα) to modulate the expression of ERα target genes. 2. **Negative regulation of DNA-templated transcription:** RBFOX2 acts as a transcriptional corepressor, regulating the expression of target genes involved in DNA replication and repair. 3. **Regulation of alternative mRNA splicing:** RBFOX2 influences the assembly of the spliceosome complex, leading to the generation of alternatively spliced mRNAs. 4. **Signaling by FGFR2:** RBFOX2 interacts with fibroblast growth factor receptor 2 (FGFR2) to modulate the expression of FGFR2 target genes. 5. **Regulation of cell population proliferation:** RBFOX2 influences cell proliferation by regulating the expression of genes involved in cell cycle progression. **Clinical Significance:** 1. **Cancer:** RBFOX2 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Neurological disorders:** RBFOX2 has been associated with neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cardiovascular disease:** RBFOX2 has been linked to cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. **Spinal muscular atrophy:** RBFOX2 has been identified as a potential therapeutic target for spinal muscular atrophy (SMA), a genetic disorder affecting motor neurons. In conclusion, RBFOX2 is a multifaceted RNA binding protein that plays a critical role in regulating gene expression, alternative splicing, and transcriptional control. Its involvement in various biological processes and diseases highlights the importance of further research into the molecular mechanisms underlying RBFOX2 function and its clinical applications.

Genular Protein ID: 1656147288

Symbol: RFOX2_HUMAN

Name: RNA binding protein fox-1 homolog 2

UniProtKB Accession Codes:

O43251 A4F5G8 A8K5Z5 B0QYY8 B0QYY9 Q0PRL5 Q0VH35 Q5TF71 Q6IC09 Q8TD00 Q8WYB1 Q96DZ6 Q96NL7 Q9UGW4 Q9UH33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11875103

Title: A negative coregulator for the human ER.

PubMed ID: 11875103

DOI: 10.1210/mend.16.3.0787

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 390
  • Mass: 41374
  • Checksum: 40D6C8C40764B317
  • Sequence:
    • MQNEPLTPGY HGFPARDSQG NQEPTTTPDA MVQPFTTIPF PPPPQNGIPT EYGVPHTQDY 
AGQTGEHNLT LYGSTQAHGE QSSNSPSTQN GSLTTEGGAQ TDGQQSQTQS SENSESKSTP 
KRLHVSNIPF RFRDPDLRQM FGQFGKILDV EIIFNERGSK GFGFVTFENS ADADRAREKL 
HGTVVEGRKI EVNNATARVM TNKKMVTPYA NGWKLSPVVG AVYGPELYAA SSFQADVSLG 
NDAAVPLSGR GGINTYIPLI SLPLVPGFPY PTAATTAAAF RGAHLRGRGR TVYGAVRAVP 
PTAIPAYPGV VYQDGFYGAD LYGGYAAYRY AQPATATAAT AAAAAAAAYS DGYGRVYTAD 
PYHALAPAAS YGVGAVASLY RGGYSRFAPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.