Details for: SEZ6L

Gene ID: 23544

Symbol: SEZ6L

Ensembl ID: ENSG00000100095

Description: seizure related 6 homolog like

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.66
    Marker Score: 34,931
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.68
    Marker Score: 30,507
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.81
    Marker Score: 6,766
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.09
    Marker Score: 2,376
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 4.01
    Marker Score: 16,707
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.21
    Marker Score: 1,799
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.62
    Marker Score: 10,138
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.59
    Marker Score: 98,373
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.52
    Marker Score: 10,439
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.5
    Marker Score: 4,194
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.44
    Marker Score: 6,960
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.34
    Marker Score: 9,037
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.29
    Marker Score: 2,826
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.26
    Marker Score: 17,286
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.22
    Marker Score: 735
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.17
    Marker Score: 4,977
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.13
    Marker Score: 16,070
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.02
    Marker Score: 20,897
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2
    Marker Score: 18,777
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,107
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.87
    Marker Score: 3,878
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.84
    Marker Score: 707
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.82
    Marker Score: 17,265
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8
    Marker Score: 110,635
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.77
    Marker Score: 7,214
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.68
    Marker Score: 7,794
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,548
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.63
    Marker Score: 3,098
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.59
    Marker Score: 1,977
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.55
    Marker Score: 23,237
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.53
    Marker Score: 1,677
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.49
    Marker Score: 599
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,903
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.44
    Marker Score: 692
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.4
    Marker Score: 8,395
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.39
    Marker Score: 720
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50,186
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.34
    Marker Score: 1,006
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.22
    Marker Score: 548
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.18
    Marker Score: 2,404
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16,806
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7,123
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2,580
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.98
    Marker Score: 19,518
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.95
    Marker Score: 1,272
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.91
    Marker Score: 3,054
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 806
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.8
    Marker Score: 270
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.78
    Marker Score: 238
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.77
    Marker Score: 244
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 457
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.73
    Marker Score: 306
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.69
    Marker Score: 188
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.65
    Marker Score: 730
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.64
    Marker Score: 297
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.57
    Marker Score: 160
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.52
    Marker Score: 148
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.52
    Marker Score: 17,418
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.51
    Marker Score: 148
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.5
    Marker Score: 218
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 242
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.49
    Marker Score: 10,424
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.48
    Marker Score: 314
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.46
    Marker Score: 4,679
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.44
    Marker Score: 99
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.41
    Marker Score: 410
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 933
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.39
    Marker Score: 142
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 167
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.36
    Marker Score: 366
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.36
    Marker Score: 129
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.36
    Marker Score: 308
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.35
    Marker Score: 141
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.35
    Marker Score: 238
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.35
    Marker Score: 398
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 120
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.33
    Marker Score: 341
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.33
    Marker Score: 311
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.32
    Marker Score: 112
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.32
    Marker Score: 654
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 322
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.32
    Marker Score: 305

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SEZ6L gene is a non-coding RNA, which suggests that it does not encode a protein. However, its expression is tightly regulated and significantly upregulated in various neuronal cell types, including neurons, glial cells, and neural progenitors. This unique characteristic positions SEZ6L as a potential regulator of gene expression, influencing the development, differentiation, and survival of neurons. **Pathways and Functions:** SEZ6L is involved in several critical pathways that govern neuronal function, including: 1. **Endoplasmic Reticulum (ER) Stress Response**: SEZ6L is expressed in ER-stressed neurons, suggesting its role in mitigating ER stress and promoting neuronal survival. 2. **Regulation of Protein Kinase C (PKC) Signaling**: SEZ6L modulates PKC signaling, a crucial pathway involved in neuronal development, differentiation, and synaptic plasticity. 3. **Synapse Maturation**: SEZ6L is expressed in synapses, where it may play a role in regulating the maturation and function of synaptic terminals. 4. **Neuronal Cell Body**: SEZ6L is also expressed in the neuronal cell body, where it may influence gene expression, neuronal differentiation, and survival. **Clinical Significance:** The SEZ6L gene has been implicated in various neurological disorders, including: 1. **Seizure Disorders**: SEZ6L has been associated with epilepsy, a disorder characterized by recurrent seizures. Alterations in SEZ6L expression may contribute to seizure susceptibility and severity. 2. **Neurodegenerative Diseases**: SEZ6L has been linked to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Dysregulation of SEZ6L may contribute to neuronal dysfunction and disease progression. 3. **Neurodevelopmental Disorders**: SEZ6L has been implicated in neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability. Alterations in SEZ6L expression may contribute to neuronal dysfunction and developmental delays. In conclusion, the SEZ6L gene is a critical regulator of neuronal function, playing a pivotal role in maintaining the integrity and function of neurons. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the molecular mechanisms underlying SEZ6L function and its clinical significance.

Genular Protein ID: 3644905147

Symbol: SE6L1_HUMAN

Name: Seizure 6-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11175339

Title: Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line.

PubMed ID: 11175339

DOI: 10.1038/sj.onc.1204031

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11992124

Title: A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer.

PubMed ID: 11992124

DOI: 10.1038/ng892

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 1024
  • Mass: 111782
  • Checksum: CBC0679E22C23B6E
  • Sequence:
  • MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 
    HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 
    SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 
    EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 
    ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 
    PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 
    RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 
    LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 
    WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 
    RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 
    EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 
    GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 
    PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 
    GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL 
    EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM 
    CYEGFELMGE VTIRCILGQP SHWNGPLPVC KVNQDSFEHA LEVAEAAAET SLEGGNMALA 
    IFIPVLIISL LLGGAYIYIT RCRYYSNLRL PLMYSHPYSQ ITVETEFDNP IYETGETREY 
    EVSI

Genular Protein ID: 903414692

Symbol: B7ZLJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1011
  • Mass: 110341
  • Checksum: 5646860FA2A83B19
  • Sequence:
  • MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 
    HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 
    SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 
    EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 
    ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 
    PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 
    RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 
    LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 
    WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 
    RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 
    EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 
    GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 
    PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 
    GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL 
    EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM 
    CYEGFELMGE VTIRCILGQP SHWNGPLPVC KEAAAETSLE GGNMALAIFI PVLIISLLLG 
    GAYIYITRCR YYSNLRLPLM YSHPYSQITV ETEFDNPIYE TGETREYEVS I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.