Details for: SYNGR4

Gene ID: 23546

Symbol: SYNGR4

Ensembl ID: ENSG00000105467

Description: synaptogyrin 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.97
    Marker Score: 6,151
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2,220
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.12
    Marker Score: 1,237
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.62
    Marker Score: 3,078
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1,457
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.23
    Marker Score: 649
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.19
    Marker Score: 377
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.17
    Marker Score: 2,048
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,819
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.07
    Marker Score: 1,542
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2,014
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.93
    Marker Score: 338
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.93
    Marker Score: 939
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.9
    Marker Score: 364
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14,126
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2,072
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 804
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.82
    Marker Score: 264
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.8
    Marker Score: 618
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 458
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 230
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 259
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 139
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.52
    Marker Score: 319
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 198
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2,979
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 443
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 195
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 395
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 162
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.37
    Marker Score: 164
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.29
    Marker Score: 178
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 74
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.23
    Marker Score: 1,981
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 63
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.17
    Marker Score: 105
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.13
    Marker Score: 167
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 112
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.12
    Marker Score: 233
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.06
    Marker Score: 154
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 113
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 65

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SYNGR4 is a cytoplasmic protein that belongs to the synaptogyrin family, which consists of six members (SNG1-6). SYNGR4 is characterized by its high sequence similarity to other synaptogyrins, with a predicted molecular weight of approximately 40 kDa. This protein is highly expressed in various tissues, including the kidney, blood vessels, and the intestinal epithelium. Notably, SYNGR4 is also expressed in germ cells, suggesting its potential role in reproductive biology. **Pathways and Functions:** SYNGR4 is involved in several key cellular processes, including: 1. **Neuromuscular junction formation and function**: SYNGR4 is essential for the regulation of synaptic vesicle fusion and neurotransmitter release at the neuromuscular junction, which is critical for muscle contraction and relaxation. 2. **Endothelial cell function**: SYNGR4 is highly expressed in endothelial cells, where it plays a role in maintaining vascular homeostasis and regulating blood flow. 3. **Epithelial cell function**: SYNGR4 is also expressed in epithelial cells, including those lining the kidney, intestine, and blood vessels, where it may contribute to the regulation of ion transport and fluid balance. 4. **Germ cell function**: SYNGR4 is expressed in germ cells, where it may play a role in the regulation of spermatogenesis and oogenesis. **Clinical Significance:** Dysregulation of SYNGR4 has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in the SNGR1 gene, which encodes a synaptogyrin homolog, have been associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cardiovascular disease**: Alterations in SYNGR4 expression have been linked to cardiovascular disease, including hypertension and atherosclerosis. 3. **Kidney disease**: SYNGR4 may play a role in the regulation of renal function and the development of kidney disease, including chronic kidney disease (CKD) and acute kidney injury (AKI). **Therapeutic Applications:** Given the potential role of SYNGR4 in various diseases, therapeutic strategies targeting this gene may offer new avenues for treatment. Potential applications include: 1. **Neuroprotection**: Modulating SYNGR4 expression or activity may provide a novel therapeutic approach for neurodegenerative diseases. 2. **Cardiovascular disease**: Targeting SYNGR4 may help to regulate blood pressure and reduce the risk of cardiovascular disease. 3. **Kidney disease**: SYNGR4 may serve as a therapeutic target for the treatment of kidney disease, including CKD and AKI. In conclusion, SYNGR4 is a multifunctional protein that plays a critical role in various cellular processes, including neuromuscular junction formation, endothelial cell function, and germ cell function. Dysregulation of SYNGR4 has been implicated in various diseases, and therapeutic strategies targeting this gene may offer new avenues for treatment. Further research is needed to fully elucidate the mechanisms by which SYNGR4 regulates cellular function and to explore its potential as a therapeutic target.

Genular Protein ID: 1139976707

Symbol: SNG4_HUMAN

Name: Synaptogyrin-4

UniProtKB Accession Codes:

O95473 Q3KP58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 234
  • Mass: 25820
  • Checksum: 1CE517E82E2ABDE0
  • Sequence:
    • MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM ESPQLHCILN 
SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT AFQLLDFILA VLWAVVWFMG 
FCFLANQWQH SPPKEFLLGS SSAQAAIAFT FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL 
DEGGMVLTTL PLPSANSPVN MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.