Details for: LILRA4

Gene ID: 23547

Symbol: LILRA4

Ensembl ID: ENSG00000239961

Description: leukocyte immunoglobulin like receptor A4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.24
    Marker Score: 2,256
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.29
    Marker Score: 1,402
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.16
    Marker Score: 677
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,812
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 653
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,055
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,462
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 661
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.75
    Marker Score: 437
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.71
    Marker Score: 188
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.53
    Marker Score: 932
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.51
    Marker Score: 276
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.45
    Marker Score: 207
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.41
    Marker Score: 144
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.4
    Marker Score: 389
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 306
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.32
    Marker Score: 186
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.3
    Marker Score: 182
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.29
    Marker Score: 176
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 501
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.23
    Marker Score: 595
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 216
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.21
    Marker Score: 253
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.21
    Marker Score: 106
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.18
    Marker Score: 129
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.16
    Marker Score: 195
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.15
    Marker Score: 93
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.15
    Marker Score: 106
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 221
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.13
    Marker Score: 302
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.12
    Marker Score: 111
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.12
    Marker Score: 94
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.12
    Marker Score: 150
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.1
    Marker Score: 249
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.1
    Marker Score: 411
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.07
    Marker Score: 763
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 120
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 111
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.05
    Marker Score: 319
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.05
    Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inhibitory Receptor**: LILRA4 is a member of the LILR family, characterized by its inhibitory function on immune cells. 2. **Expression on Immune Cells**: LILRA4 is expressed on various immune cells, including follicular B cells, granulocytes, and GABAergic interneurons in the brain. 3. **Negative Regulation of Immune Responses**: LILRA4 modulates the activity of immune cells, influencing the outcome of immune responses and preventing excessive immune activation. 4. **Involvement in Autoimmune Diseases**: LILRA4 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. **Pathways and Functions:** 1. **Adaptive Immune System**: LILRA4 regulates the activity of T cells and B cells, influencing the outcome of adaptive immune responses. 2. **Coreceptor Activity**: LILRA4 interacts with other immune receptors, modulating their activity and influencing immune cell function. 3. **Cytokine-Mediated Signaling Pathway**: LILRA4 regulates the production of cytokines, which are essential for immune cell function and immune responses. 4. **Negative Regulation of Immune Responses**: LILRA4 acts as a negative regulator of immune responses, preventing excessive immune activation and tissue damage. **Clinical Significance:** 1. **Autoimmune Diseases**: LILRA4 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Understanding the mechanisms by which LILRA4 regulates immune responses may lead to the development of novel therapeutic strategies for these diseases. 2. **Immunotherapy**: LILRA4 may be a target for immunotherapy, as its expression on immune cells may make it an attractive candidate for the development of cancer vaccines. 3. **Infectious Diseases**: LILRA4 may also play a role in the regulation of immune responses to infectious diseases, highlighting its importance in preventing excessive immune activation and tissue damage. In conclusion, LILRA4 is a critical regulator of immune responses, influencing the outcome of adaptive and innate immune responses. Further research is needed to fully understand the mechanisms by which LILRA4 regulates immune function and to explore its clinical significance in the prevention and treatment of autoimmune diseases and infectious diseases.

Genular Protein ID: 2920554204

Symbol: LIRA4_HUMAN

Name: CD85 antigen-like family member G

UniProtKB Accession Codes:

P59901 Q32MC4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16777052

Title: Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.

PubMed ID: 16777052

DOI: 10.1016/j.ab.2006.05.024

PubMed ID: 16735691

Title: Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production.

PubMed ID: 16735691

DOI: 10.1084/jem.20052454

PubMed ID: 19564354

Title: Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.

PubMed ID: 19564354

DOI: 10.1084/jem.20090547

PubMed ID: 24586760

Title: Effect of immunoglobin-like transcript 7 cross-linking on plasmacytoid dendritic cells differentiation into antigen-presenting cells.

PubMed ID: 24586760

DOI: 10.1371/journal.pone.0089414

PubMed ID: 26172439

Title: Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic Cells.

PubMed ID: 26172439

DOI: 10.1371/journal.ppat.1005024

Sequence Information:

  • Length: 499
  • Mass: 55181
  • Checksum: DE8728D2BEC28141
  • Sequence:
    • MTLILTSLLF FGLSLGPRTR VQAENLLKPI LWAEPGPVIT WHNPVTIWCQ GTLEAQGYRL 
DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY 
SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF 
PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL 
TLQCGSDVGY IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN 
VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM FTFLLTKEGA 
AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS SNPYLLSHPS EPLELVVSGA 
TETLNPAQKK SDSKTAPHLQ DYTVENLIRM GVAGLVLLFL GILLFEAQHS QRSPPRCSQE 
ANSRKDNAPF RVVEPWEQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.