Details for: TSPAN15

Gene ID: 23555

Symbol: TSPAN15

Ensembl ID: ENSG00000099282

Description: tetraspanin 15

Associated with

Other Information

Genular Protein ID: 1714429780

Symbol: TSN15_HUMAN

Name: Tetraspanin-15

UniProtKB Accession Codes:

O95858 Q6UW79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 3 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26686862

Title: TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.

PubMed ID: 26686862

DOI: 10.1007/s00018-015-2111-z

PubMed ID: 30463011

Title: A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.

PubMed ID: 30463011

DOI: 10.1016/j.celrep.2018.10.088

PubMed ID: 31792032

Title: TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life.

PubMed ID: 31792032

DOI: 10.26508/lsa.201900444

PubMed ID: 34739841

Title: Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.

PubMed ID: 34739841

DOI: 10.1016/j.str.2021.10.007

PubMed ID: 37516108

Title: Structural basis for membrane-proximal proteolysis of substrates by ADAM10.

PubMed ID: 37516108

DOI: 10.1016/j.cell.2023.06.026

Sequence Information:

  • Length: 294
  • Mass: 33165
  • Checksum: 71A6DC64D6CA6BAE
  • Sequence:
    • MPRGDSEQVR YCARFSYLWL KFSLIIYSTV FWLIGALVLS VGIYAEVERQ KYKTLESAFL 
APAIILILLG VVMFMVSFIG VLASLRDNLY LLQAFMYILG ICLIMELIGG VVALTFRNQT 
IDFLNDNIRR GIENYYDDLD FKNIMDFVQK KFKCCGGEDY RDWSKNQYHD CSAPGPLACG 
VPYTCCIRNT TEVVNTMCGY KTIDKERFSV QDVIYVRGCT NAVIIWFMDN YTIMAGILLG 
ILLPQFLGVL LTLLYITRVE DIIMEHSVTD GLLGPGAKPS VEAAGTGCCL CYPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.