Details for: PADI4

Gene ID: 23569

Symbol: PADI4

Ensembl ID: ENSG00000159339

Description: peptidyl arginine deiminase 4

Associated with

Other Information

Genular Protein ID: 527161722

Symbol: PADI4_HUMAN

Name: Protein-arginine deiminase type-4

UniProtKB Accession Codes:

Q9UM07 A8K392 B2RBW0 Q5VTZ8 Q70SX4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 27 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 6 DrugCentral 1 EC 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 19 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10488123

Title: Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3).

PubMed ID: 10488123

DOI: 10.1074/jbc.274.39.27786

PubMed ID: 15087120

Title: Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.

PubMed ID: 15087120

DOI: 10.1016/j.gene.2003.12.038

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11435484

Title: Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils.

PubMed ID: 11435484

PubMed ID: 12833157

Title: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.

PubMed ID: 12833157

DOI: 10.1038/ng1206

PubMed ID: 15339660

Title: Histone deimination antagonizes arginine methylation.

PubMed ID: 15339660

DOI: 10.1016/j.cell.2004.08.020

PubMed ID: 15345777

Title: Human PAD4 regulates histone arginine methylation levels via demethylimination.

PubMed ID: 15345777

DOI: 10.1126/science.1101400

PubMed ID: 15629448

Title: Comparison of enzymatic properties between hPADI2 and hPADI4.

PubMed ID: 15629448

DOI: 10.1016/j.bbrc.2004.11.152

PubMed ID: 15731352

Title: Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.

PubMed ID: 15731352

DOI: 10.1073/pnas.0407159102

PubMed ID: 18209087

Title: Histone deimination as a response to inflammatory stimuli in neutrophils.

PubMed ID: 18209087

DOI: 10.4049/jimmunol.180.3.1895

PubMed ID: 20201080

Title: Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation.

PubMed ID: 20201080

DOI: 10.1002/art.27439

PubMed ID: 15247907

Title: Structural basis for Ca(2+)-induced activation of human PAD4.

PubMed ID: 15247907

DOI: 10.1038/nsmb799

PubMed ID: 16567635

Title: Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4.

PubMed ID: 16567635

DOI: 10.1073/pnas.0509639103

PubMed ID: 17002273

Title: Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.

PubMed ID: 17002273

DOI: 10.1021/bi061180d

PubMed ID: 21245532

Title: Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene.

PubMed ID: 21245532

DOI: 10.1107/s0907444910051711

PubMed ID: 21882827

Title: The development of N-alpha-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

PubMed ID: 21882827

DOI: 10.1021/jm2008985

PubMed ID: 22004374

Title: Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.

PubMed ID: 22004374

DOI: 10.1021/cb200258q

PubMed ID: 15338034

Title: High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach.

PubMed ID: 15338034

DOI: 10.1007/s00109-004-0584-6

Sequence Information:

  • Length: 663
  • Mass: 74079
  • Checksum: 79D7AF7B3D307A3B
  • Sequence:
    • MAQGTLIRVT PEQPTHAVCV LGTLTQLDIC SSAPEDCTSF SINASPGVVV DIAHGPPAKK 
KSTGSSTWPL DPGVEVTLTM KVASGSTGDQ KVQISYYGPK TPPVKALLYL TGVEISLCAD 
ITRTGKVKPT RAVKDQRTWT WGPCGQGAIL LVNCDRDNLE SSAMDCEDDE VLDSEDLQDM 
SLMTLSTKTP KDFFTNHTLV LHVARSEMDK VRVFQATRGK LSSKCSVVLG PKWPSHYLMV 
PGGKHNMDFY VEALAFPDTD FPGLITLTIS LLDTSNLELP EAVVFQDSVV FRVAPWIMTP 
NTQPPQEVYA CSIFENEDFL KSVTTLAMKA KCKLTICPEE ENMDDQWMQD EMEIGYIQAP 
HKTLPVVFDS PRNRGLKEFP IKRVMGPDFG YVTRGPQTGG ISGLDSFGNL EVSPPVTVRG 
KEYPLGRILF GDSCYPSNDS RQMHQALQDF LSAQQVQAPV KLYSDWLSVG HVDEFLSFVP 
APDRKGFRLL LASPRSCYKL FQEQQNEGHG EALLFEGIKK KKQQKIKNIL SNKTLREHNS 
FVERCIDWNR ELLKRELGLA ESDIIDIPQL FKLKEFSKAE AFFPNMVNML VLGKHLGIPK 
PFGPVINGRC CLEEKVCSLL EPLGLQCTFI NDFFTYHIRH GEVHCGTNVR RKPFSFKWWN 
MVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.