CASP14 | ENSG00000105141 | NCBI 23581

Details for: CASP14

Gene ID: 23581

Symbol: CASP14

Ensembl ID: ENSG00000105141

Description: caspase 14

Associated with

Developmental biology
(R-HSA-1266738)
Formation of the cornified envelope
(R-HSA-6809371)
Cornification
(GO:0070268)
Cornified envelope
(GO:0001533)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epidermis development
(GO:0008544)
Keratin filament
(GO:0045095)
Keratinization
(GO:0031424)
Mitochondrion
(GO:0005739)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of neuron apoptotic process
(GO:0043525)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)

Other Information

Proteins

Caspase-14

Genular Protein ID: 3013218132

Symbol: CASPE_HUMAN

Name: Caspase-14

UniProtKB Accession Codes:

P31944 O95823 Q3SYC9

Database IDs:

Citations:

PubMed ID: 11062009

Title: Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation.

PubMed ID: 11062009

DOI: 10.1006/bbrc.2000.3698

PubMed ID: 12181750

Title: Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.

PubMed ID: 12181750

DOI: 10.1038/sj.cdd.4401061

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11175259

Title: Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.

PubMed ID: 11175259

DOI: 10.1038/sj.cdd.4400785

PubMed ID: 12200134

Title: Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.

PubMed ID: 12200134

DOI: 10.1016/s0006-291x(02)02015-6

PubMed ID: 15301553

Title: Activation and substrate specificity of caspase-14.

PubMed ID: 15301553

DOI: 10.1021/bi0498048

PubMed ID: 15556625

Title: Stratum corneum-derived caspase-14 is catalytically active.

PubMed ID: 15556625

DOI: 10.1016/j.febslet.2004.10.046

PubMed ID: 16854378

Title: Expression and characterization of constitutively active human caspase-14.

PubMed ID: 16854378

DOI: 10.1016/j.bbrc.2006.06.156

PubMed ID: 19960512

Title: Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody.

PubMed ID: 19960512

DOI: 10.1002/jcb.22425

PubMed ID: 22825846

Title: Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form.

PubMed ID: 22825846

DOI: 10.1074/jbc.m112.357467

PubMed ID: 25121097

Title: Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.

PubMed ID: 25121097

DOI: 10.1155/2014/417986

PubMed ID: 24743736

Title: Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation.

PubMed ID: 24743736

DOI: 10.1038/cddis.2014.145

PubMed ID: 27494380

Title: Whole-Exome-Sequencing reveals small deletions in CASP14 in patients with autosomal recessive inherited ichthyosis.

PubMed ID: 27494380

DOI: 10.2340/00015555-2510

Sequence Information:

Length: 242
Mass: 27680
Checksum: E539FB7E8DD808A2
Sequence:

MSNPRSLEEE KYDMSGARLA LILCVTKARE GSEEDLDALE HMFRQLRFES TMKRDPTAEQ 
FQEELEKFQQ AIDSREDPVS CAFVVLMAHG REGFLKGEDG EMVKLENLFE ALNNKNCQAL 
RAKPKVYIIQ ACRGEQRDPG ETVGGDEIVM VIKDSPQTIP TYTDALHVYS TVEGYIAYRH 
DQKGSCFIQT LVDVFTKRKG HILELLTEVT RRMAEAELVQ EGKARKTNPE IQSTLRKRLY 
LQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CASP14

Associated with

Other Information

Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation. PubMed ID: 11062009

Expression and transcriptional regulation of caspase-14 in simple and complex epithelia. PubMed ID: 12181750

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. PubMed ID: 11175259

Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation. PubMed ID: 12200134

Activation and substrate specificity of caspase-14. PubMed ID: 15301553

Stratum corneum-derived caspase-14 is catalytically active. PubMed ID: 15556625

Expression and characterization of constitutively active human caspase-14. PubMed ID: 16854378

Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody. PubMed ID: 19960512

Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form. PubMed ID: 22825846

Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema. PubMed ID: 25121097

Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation. PubMed ID: 24743736

Whole-Exome-Sequencing reveals small deletions in CASP14 in patients with autosomal recessive inherited ichthyosis. PubMed ID: 27494380