SMUG1 | ENSG00000123415 | NCBI 23583

Details for: SMUG1

Gene ID: 23583

Symbol: SMUG1

Ensembl ID: ENSG00000123415

Description: single-strand-selective monofunctional uracil-DNA glycosylase 1

Associated with

Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Displacement of dna glycosylase by apex1
(R-HSA-110357)
Dna repair
(R-HSA-73894)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Base-excision repair
(GO:0006284)
Cytosol
(GO:0005829)
Depyrimidination
(GO:0045008)
Dna binding
(GO:0003677)
Dna n-glycosylase activity
(GO:0019104)
Fibrillar center
(GO:0001650)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Oxidized pyrimidine nucleobase lesion dna n-glycosylase activity
(GO:0000703)
Protein binding
(GO:0005515)
Single-strand selective uracil dna n-glycosylase activity
(GO:0017065)
Uracil dna n-glycosylase activity
(GO:0004844)

Other Information

Proteins

Single-strand selective monofunctional uracil DNA glycosylase
A0A0S2Z526_HUMAN

Genular Protein ID: 3255917049

Symbol: SMUG1_HUMAN

Name: Single-strand selective monofunctional uracil DNA glycosylase

UniProtKB Accession Codes:

Q53HV7 A8K2K9 O95862 Q0D2M0 Q8NB71 Q9BWC8

Database IDs:

Citations:

PubMed ID: 10074426

Title: Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors.

PubMed ID: 10074426

DOI: 10.1016/s0960-9822(99)80087-6

PubMed ID: 12718543

Title: Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.

PubMed ID: 12718543

DOI: 10.1021/bi0273213

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11526119

Title: Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1.

PubMed ID: 11526119

DOI: 10.1074/jbc.m106953200

PubMed ID: 12161446

Title: hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.

PubMed ID: 12161446

DOI: 10.1074/jbc.m207107200

PubMed ID: 15466595

Title: Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.

PubMed ID: 15466595

DOI: 10.1093/nar/gkh859

Sequence Information:

Length: 270
Mass: 29862
Checksum: 2AB18F6F757F6DD7
Sequence:

MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY 
AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE 
HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA 
ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP 
SPRNPQANKG WEAVAKERLN ELGLLPLLLK

Genular Protein ID: 547318377

Symbol: A0A0S2Z526_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z526

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 177
Mass: 19627
Checksum: 9525274EE6797F61
Sequence:

MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY 
AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE 
HPKRPVLGLE CPQSEGPRQS MGHEIKSELL MGGCSWIRGK IQCDRVQVRR PGFSSQL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SMUG1

Associated with

Other Information

Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. PubMed ID: 10074426

Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. PubMed ID: 12718543

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. PubMed ID: 11526119

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. PubMed ID: 12161446

Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. PubMed ID: 15466595

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637