Details for: RIGI
Associated with
Other Information
Genular Protein ID: 3283655663
Symbol: RIGI_HUMAN
Name: DEAD box protein 58
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11890704
Title: Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2.
PubMed ID: 11890704
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15181474
Title: Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells.
PubMed ID: 15181474
DOI: 10.1139/o04-041
PubMed ID: 15219805
Title: Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma.
PubMed ID: 15219805
PubMed ID: 15208624
Title: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
PubMed ID: 15208624
DOI: 10.1038/ni1087
PubMed ID: 16125763
Title: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
PubMed ID: 16125763
PubMed ID: 16281057
Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
PubMed ID: 16281057
PubMed ID: 15708988
Title: Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
PubMed ID: 15708988
PubMed ID: 16153868
Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.
PubMed ID: 16153868
PubMed ID: 16127453
Title: IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
PubMed ID: 16127453
DOI: 10.1038/ni1243
PubMed ID: 16009940
Title: Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
PubMed ID: 16009940
PubMed ID: 17392790
Title: TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
PubMed ID: 17392790
DOI: 10.1038/nature05732
PubMed ID: 17190814
Title: Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
PubMed ID: 17190814
PubMed ID: 17460044
Title: Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
PubMed ID: 17460044
PubMed ID: 18636086
Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
PubMed ID: 18636086
PubMed ID: 18057259
Title: Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation.
PubMed ID: 18057259
DOI: 10.1128/jvi.01650-07
PubMed ID: 18724357
Title: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
PubMed ID: 18724357
DOI: 10.1038/nature07317
PubMed ID: 19631370
Title: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.
PubMed ID: 19631370
PubMed ID: 19576794
Title: Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
PubMed ID: 19576794
PubMed ID: 19017631
Title: Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
PubMed ID: 19017631
PubMed ID: 19122199
Title: Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions.
PubMed ID: 19122199
PubMed ID: 19211564
Title: Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
PubMed ID: 19211564
PubMed ID: 19419966
Title: The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
PubMed ID: 19419966
PubMed ID: 19193793
Title: Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I.
PubMed ID: 19193793
DOI: 10.1128/jvi.02434-08
PubMed ID: 19609254
Title: RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
PubMed ID: 19609254
DOI: 10.1038/ni.1779
PubMed ID: 19484123
Title: REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.
PubMed ID: 19484123
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20434986
Title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
PubMed ID: 20434986
PubMed ID: 20368735
Title: The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
PubMed ID: 20368735
DOI: 10.1038/cr.2010.41
PubMed ID: 21175414
Title: Function and regulation of retinoic acid-inducible gene-I.
PubMed ID: 21175414
PubMed ID: 20127681
Title: DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
PubMed ID: 20127681
PubMed ID: 20007272
Title: Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction.
PubMed ID: 20007272
DOI: 10.1128/jvi.01362-09
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21616437
Title: Immune signaling by RIG-I-like receptors.
PubMed ID: 21616437
PubMed ID: 21884169
Title: RIG-I-like receptors: cytoplasmic sensors for non-self RNA.
PubMed ID: 21884169
PubMed ID: 21233210
Title: ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner.
PubMed ID: 21233210
PubMed ID: 21742966
Title: Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5' phosphorylation of RNA molecules.
PubMed ID: 21742966
PubMed ID: 21813773
Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.
PubMed ID: 21813773
PubMed ID: 20950133
Title: Retinoic acid-inducible gene-I-like receptors.
PubMed ID: 20950133
PubMed ID: 21068236
Title: Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response.
PubMed ID: 21068236
DOI: 10.1128/jvi.01734-10
PubMed ID: 21791617
Title: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
PubMed ID: 21791617
DOI: 10.1128/mcb.01368-10
PubMed ID: 21102435
Title: ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
PubMed ID: 21102435
DOI: 10.1038/ni.1963
PubMed ID: 22152002
Title: Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I.
PubMed ID: 22152002
PubMed ID: 22301138
Title: Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.
PubMed ID: 22301138
DOI: 10.1128/jvi.06713-11
PubMed ID: 22607805
Title: The mitochondrial targeting chaperone 14-3-3epsilon regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
PubMed ID: 22607805
PubMed ID: 23399697
Title: Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.
PubMed ID: 23399697
DOI: 10.1038/icb.2013.7
PubMed ID: 23843640
Title: Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1.
PubMed ID: 23843640
DOI: 10.1128/jvi.01073-13
PubMed ID: 23950712
Title: A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.
PubMed ID: 23950712
PubMed ID: 24755855
Title: TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.
PubMed ID: 24755855
DOI: 10.1093/jmcb/mju005
PubMed ID: 24390337
Title: Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
PubMed ID: 24390337
DOI: 10.1128/jvi.02712-13
PubMed ID: 24478431
Title: Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses.
PubMed ID: 24478431
DOI: 10.1128/jvi.03021-13
PubMed ID: 26471729
Title: A non-canonical role of the p97 complex in RIG-I antiviral signaling.
PubMed ID: 26471729
PubMed ID: 25228397
Title: ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.
PubMed ID: 25228397
DOI: 10.1159/000365971
PubMed ID: 27824081
Title: The nucleolar protein GLTSCR2 is required for efficient viral replication.
PubMed ID: 27824081
DOI: 10.1038/srep36226
PubMed ID: 27866900
Title: A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
PubMed ID: 27866900
PubMed ID: 25620203
Title: Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome.
PubMed ID: 25620203
PubMed ID: 27312109
Title: RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling.
PubMed ID: 27312109
PubMed ID: 28469175
Title: Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.
PubMed ID: 28469175
DOI: 10.1038/ncomms15138
PubMed ID: 29117565
Title: The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.
PubMed ID: 29117565
PubMed ID: 29288164
Title: LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation.
PubMed ID: 29288164
PubMed ID: 30193849
Title: The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors.
PubMed ID: 30193849
PubMed ID: 31006531
Title: Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.
PubMed ID: 31006531
PubMed ID: 32715615
Title: Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
PubMed ID: 32715615
PubMed ID: 32027733
Title: USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I.
PubMed ID: 32027733
Title: METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
PubMed ID: 34313226
Title: RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination.
PubMed ID: 34313226
DOI: 10.7554/elife.68958
PubMed ID: 34935440
Title: The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I To Suppress Innate Immunity.
PubMed ID: 34935440
DOI: 10.1128/jvi.01510-21
PubMed ID: 35263596
Title: The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.
PubMed ID: 35263596
PubMed ID: 36793726
Title: Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.
PubMed ID: 36793726
PubMed ID: 18243112
Title: The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
PubMed ID: 18243112
PubMed ID: 18242112
Title: Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.
PubMed ID: 18242112
PubMed ID: 25018021
Title: Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
PubMed ID: 25018021
Sequence Information:
- Length: 925
- Mass: 106600
- Checksum: BF0D501C395BAE25
- Sequence:
MTTEQRRSLQ AFQDYIRKTL DPTYILSYMA PWFREEEVQY IQAEKNNKGP MEAATLFLKF LLELQEEGWF RGFLDALDHA GYSGLYEAIE SWDFKKIEKL EEYRLLLKRL QPEFKTRIIP TDIISDLSEC LINQECEEIL QICSTKGMMA GAEKLVECLL RSDKENWPKT LKLALEKERN KFSELWIVEK GIKDVETEDL EDKMETSDIQ IFYQEDPECQ NLSENSCPPS EVSDTNLYSP FKPRNYQLEL ALPAMKGKNT IICAPTGCGK TFVSLLICEH HLKKFPQGQK GKVVFFANQI PVYEQQKSVF SKYFERHGYR VTGISGATAE NVPVEQIVEN NDIIILTPQI LVNNLKKGTI PSLSIFTLMI FDECHNTSKQ HPYNMIMFNY LDQKLGGSSG PLPQVIGLTA SVGVGDAKNT DEALDYICKL CASLDASVIA TVKHNLEELE QVVYKPQKFF RKVESRISDK FKYIIAQLMR DTESLAKRIC KDLENLSQIQ NREFGTQKYE QWIVTVQKAC MVFQMPDKDE ESRICKALFL YTSHLRKYND ALIISEHARM KDALDYLKDF FSNVRAAGFD EIEQDLTQRF EEKLQELESV SRDPSNENPK LEDLCFILQE EYHLNPETIT ILFVKTRALV DALKNWIEGN PKLSFLKPGI LTGRGKTNQN TGMTLPAQKC ILDAFKASGD HNILIATSVA DEGIDIAQCN LVILYEYVGN VIKMIQTRGR GRARGSKCFL LTSNAGVIEK EQINMYKEKM MNDSILRLQT WDEAVFREKI LHIQTHEKFI RDSQEKPKPV PDKENKKLLC RKCKALACYT ADVRVIEECH YTVLGDAFKE CFVSRPHPKP KQFSSFEKRA KIFCARQNCS HDWGIHVKYK TFEIPVIKIE SFVVEDIATG VQTLYSKWKD FHFEKIPFDP AEMSK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.