ORC3 | ENSG00000135336 | NCBI 23595

Details for: ORC3

Gene ID: 23595

Symbol: ORC3

Ensembl ID: ENSG00000135336

Description: origin recognition complex subunit 3

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Activation of the pre-replicative complex
(R-HSA-68962)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
Cdc6 association with the orc:origin complex
(R-HSA-68689)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Dna replication pre-initiation
(R-HSA-69002)
E2f-enabled inhibition of pre-replication complex formation
(R-HSA-113507)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Orc1 removal from chromatin
(R-HSA-68949)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Chromatin
(GO:0000785)
Chromosome, telomeric region
(GO:0000781)
Dna replication
(GO:0006260)
Dna replication initiation
(GO:0006270)
Dna replication origin binding
(GO:0003688)
Dna replication preinitiation complex
(GO:0031261)
Glial cell proliferation
(GO:0014009)
Neural precursor cell proliferation
(GO:0061351)
Nuclear body
(GO:0016604)
Nuclear origin of replication recognition complex
(GO:0005664)
Nuclear pre-replicative complex
(GO:0005656)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Origin recognition complex
(GO:0000808)
Protein binding
(GO:0005515)
Regulation of dna replication
(GO:0006275)

Other Information

Proteins

Origin recognition complex subunit 3

Genular Protein ID: 3904857242

Symbol: ORC3_HUMAN

Name: Origin recognition complex subunit 3

UniProtKB Accession Codes:

Q9UBD5 A2A2T5 B4E025 Q13565 Q53GY6 Q5T159 Q6IUY7 Q86TN5 Q9UG44 Q9UNT6

Database IDs:

Citations:

PubMed ID: 10402192

Title: Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant.

PubMed ID: 10402192

DOI: 10.1016/s0896-6273(00)80752-7

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12909626

Title: The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.

PubMed ID: 12909626

DOI: 10.1074/jbc.m307535200

PubMed ID: 17716973

Title: ATP-dependent assembly of the human origin recognition complex.

PubMed ID: 17716973

DOI: 10.1074/jbc.m705905200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22427655

Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.

PubMed ID: 22427655

DOI: 10.1074/jbc.m111.337980

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31160578

Title: The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.

PubMed ID: 31160578

DOI: 10.1038/s41467-019-10321-x

Sequence Information:

Length: 711
Mass: 82254
Checksum: E713569A11B39B1C
Sequence:

MATSSMSKGC FVFKPNSKKR KISLPIEDYF NKGKNEPEDS KLRFETYQLI WQQMKSENER 
LQEELNKNLF DNLIEFLQKS HSGFQKNSRD LGGQIKLREI PTAALVLGVN VTDHDLTFGS 
LTEALQNNVT PYVVSLQAKD CPDMKHFLQK LISQLMDCCV DIKSKEEESV HVTQRKTHYS 
MDSLSSWYMT VTQKTDPKML SKKRTTSSQW QSPPVVVILK DMESFATKVL QDFIIISSQH 
LHEFPLILIF GIATSPIIIH RLLPHAVSSL LCIELFQSLS CKEHLTTVLD KLLLTTQFPF 
KINEKVLQVL TNIFLYHDFS VQNFIKGLQL SLLEHFYSQP LSVLCCNLPE AKRRINFLSN 
NQCENIRRLP SFRRYVEKQA SEKQVALLTN ERYLKEETQL LLENLHVYHM NYFLVLRCLH 
KFTSSLPKYP LGRQIRELYC TCLEKNIWDS EEYASVLQLL RMLAKDELMT ILEKCFKVFK 
SYCENHLGST AKRIEEFLAQ FQSLDETKEE EDASGSQPKG LQKTDLYHLQ KSLLEMKELR 
RSKKQTKFEV LRENVVNFID CLVREYLLPP ETQPLHEVVY FSAAHALREH LNAAPRIALH 
TALNNPYYYL KNEALKSEEG CIPNIAPDIC IAYKLHLECS RLINLVDWSE AFATVVTAAE 
KMDANSATSE EMNEIIHARF IRAVSELELL GFIKPTKQKT DHVARLTWGG C

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ORC3

Associated with

Other Information

Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. PubMed ID: 10402192

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle. PubMed ID: 12909626

ATP-dependent assembly of the human origin recognition complex. PubMed ID: 17716973

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. PubMed ID: 22427655

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. PubMed ID: 31160578