OPN3 | ENSG00000054277 | NCBI 23596

Details for: OPN3

Gene ID: 23596

Symbol: OPN3

Ensembl ID: ENSG00000054277

Description: opsin 3

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Opsins
(R-HSA-419771)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
11-cis retinal binding
(GO:0005502)
All-trans retinal binding
(GO:0005503)
Cellular response to light stimulus
(GO:0071482)
Cellular response to uv-a
(GO:0071492)
Cytoplasm
(GO:0005737)
Detection of light stimulus
(GO:0009583)
Detection of visible light
(GO:0009584)
G protein-coupled photoreceptor activity
(GO:0008020)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Keratinocyte differentiation
(GO:0030216)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of melanin biosynthetic process
(GO:0048022)
Photoreceptor activity
(GO:0009881)
Photoreceptor outer segment
(GO:0001750)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Positive regulation of cellular respiration
(GO:1901857)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of melanin biosynthetic process
(GO:0048023)
Protein binding
(GO:0005515)
Regulation of circadian rhythm
(GO:0042752)
Response to blue light
(GO:0009637)

Other Information

Proteins

Opsin-3

Genular Protein ID: 868924945

Symbol: OPN3_HUMAN

Name: Opsin-3

UniProtKB Accession Codes:

Q9H1Y3 Q8IX08 Q9Y344

Database IDs:

Citations:

PubMed ID: 10234000

Title: Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain.

PubMed ID: 10234000

DOI: 10.1523/jneurosci.19-10-03681.1999

PubMed ID: 11401433

Title: Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43.

PubMed ID: 11401433

DOI: 10.1006/geno.2001.6469

PubMed ID: 12242008

Title: Different structural organization of the encephalopsin gene in man and mouse.

PubMed ID: 12242008

DOI: 10.1016/s0378-1119(02)00799-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28842328

Title: Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3.

PubMed ID: 28842328

DOI: 10.1016/j.jid.2017.07.833

PubMed ID: 30284927

Title: Airway smooth muscle photorelaxation via opsin receptor activation.

PubMed ID: 30284927

DOI: 10.1152/ajplung.00135.2018

PubMed ID: 30168605

Title: Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing?

PubMed ID: 30168605

DOI: 10.1002/lsm.23015

PubMed ID: 31097585

Title: Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.

PubMed ID: 31097585

DOI: 10.1073/pnas.1902825116

PubMed ID: 31380578

Title: Opsin 3 is a key regulator of ultraviolet A-induced photoageing in human dermal fibroblast cells.

PubMed ID: 31380578

DOI: 10.1111/bjd.18410

PubMed ID: 31730232

Title: Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway.

PubMed ID: 31730232

DOI: 10.1111/php.13178

Sequence Information:

Length: 402
Mass: 44873
Checksum: 370F64C19F834A71
Sequence:

MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS IGLLGVGNNL 
LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV SCLRNGWVWD TVGCVWDGFS 
GSLFGIVSIA TLTVLAYERY IRVVHARVIN FSWAWRAITY IWLYSLAWAG APLLGWNRYI 
LDVHGLGCTV DWKSKDANDS SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT 
IQVIKILKYE KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS 
NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI VMSQKDGDRP 
KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR PL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: OPN3

Associated with

Other Information

Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. PubMed ID: 10234000

Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. PubMed ID: 11401433

Different structural organization of the encephalopsin gene in man and mouse. PubMed ID: 12242008

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3. PubMed ID: 28842328

Airway smooth muscle photorelaxation via opsin receptor activation. PubMed ID: 30284927

Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing? PubMed ID: 30168605

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor. PubMed ID: 31097585

Opsin 3 is a key regulator of ultraviolet A-induced photoageing in human dermal fibroblast cells. PubMed ID: 31380578

Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway. PubMed ID: 31730232