Details for: PHLDA3

Gene ID: 23612

Symbol: PHLDA3

Ensembl ID: ENSG00000174307

Description: pleckstrin homology like domain family A member 3

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cytoplasm
    (GO:0005737)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Phosphatidylinositol-3,4,5-trisphosphate binding
    (GO:0005547)
  • Phosphatidylinositol-3,4-bisphosphate binding
    (GO:0043325)
  • Phosphatidylinositol-3,5-bisphosphate binding
    (GO:0080025)
  • Phosphatidylinositol-3-phosphate binding
    (GO:0032266)
  • Phosphatidylinositol-4,5-bisphosphate binding
    (GO:0005546)
  • Phosphatidylinositol-5-phosphate binding
    (GO:0010314)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of apoptotic process
    (GO:0043065)

Other Information

Genular Protein ID: 2579366356

Symbol: PHLA3_HUMAN

Name: Pleckstrin homology-like domain family A member 3

UniProtKB Accession Codes:

Q9Y5J5 B2R5A4 Q53HD6 Q8NBW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10594239

Title: A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.

PubMed ID: 10594239

DOI: 10.1007/s003359901182

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15940259

Title: A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma.

PubMed ID: 15940259

DOI: 10.1038/sj.onc.1208755

PubMed ID: 19203586

Title: PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.

PubMed ID: 19203586

DOI: 10.1016/j.cell.2008.12.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 127
  • Mass: 13891
  • Checksum: 35014547F840D115
  • Sequence:
    • MTAAATATVL KEGVLEKRSG GLLQLWKRKR CVLTERGLQL FEAKGTGGRP KELSFARIKA 
VECVESTGRH IYFTLVTEGG GEIDFRCPLE DPGWNAQITL GLVKFKNQQA IQTVRARQSL 
GTGTLVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.