Details for: BACE1
Associated with
Other Information
Genular Protein ID: 2881642802
Symbol: BACE1_HUMAN
Name: Beta-site amyloid precursor protein cleaving enzyme 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10531052
Title: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
PubMed ID: 10531052
PubMed ID: 10591214
Title: Purification and cloning of amyloid precursor protein beta-secretase from human brain.
PubMed ID: 10591214
DOI: 10.1038/990114
PubMed ID: 10591213
Title: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
PubMed ID: 10591213
DOI: 10.1038/990107
PubMed ID: 10656250
Title: Identification of a novel aspartic proteinase (Asp 2) as beta-secretase.
PubMed ID: 10656250
PubMed ID: 11516562
Title: Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production.
PubMed ID: 11516562
PubMed ID: 10574461
Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
PubMed ID: 10574461
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10677483
Title: Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
PubMed ID: 10677483
PubMed ID: 11083922
Title: ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
PubMed ID: 11083922
PubMed ID: 11466313
Title: The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.
PubMed ID: 11466313
PubMed ID: 11953458
Title: The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.
PubMed ID: 11953458
PubMed ID: 14567678
Title: Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
PubMed ID: 14567678
DOI: 10.1021/bi035199h
PubMed ID: 15286784
Title: Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.
PubMed ID: 15286784
DOI: 10.1038/nm1088
PubMed ID: 16033761
PubMed ID: 15615712
Title: GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
PubMed ID: 15615712
PubMed ID: 15886016
Title: GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.
PubMed ID: 15886016
PubMed ID: 16965550
Title: Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
PubMed ID: 16965550
PubMed ID: 16979658
Title: Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins.
PubMed ID: 16979658
PubMed ID: 16407538
Title: Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
PubMed ID: 16407538
PubMed ID: 17425515
Title: A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.
PubMed ID: 17425515
DOI: 10.1042/bj20070040
PubMed ID: 18660751
Title: PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
PubMed ID: 18660751
PubMed ID: 19011241
Title: Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels.
PubMed ID: 19011241
PubMed ID: 20354142
Title: Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
PubMed ID: 20354142
DOI: 10.1096/fj.09-146357
PubMed ID: 20484053
Title: Ubiquitin regulates GGA3-mediated degradation of BACE1.
PubMed ID: 20484053
PubMed ID: 20826464
Title: AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.
PubMed ID: 20826464
DOI: 10.1242/jcs.068841
PubMed ID: 23109336
Title: BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.
PubMed ID: 23109336
PubMed ID: 25663301
Title: Transcriptional regulation of BACE1 by NFAT3 leads to enhanced amyloidogenic processing.
PubMed ID: 25663301
PubMed ID: 27179792
Title: BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production.
PubMed ID: 27179792
DOI: 10.1093/hmg/ddw146
PubMed ID: 27302062
Title: The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.
PubMed ID: 27302062
PubMed ID: 27084579
Title: SEPT8 modulates beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
PubMed ID: 27084579
DOI: 10.1242/jcs.185215
PubMed ID: 11021803
Title: Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
PubMed ID: 11021803
PubMed ID: 12206667
Title: Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.
PubMed ID: 12206667
DOI: 10.1021/bi026232n
PubMed ID: 15096037
Title: Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis.
PubMed ID: 15096037
DOI: 10.1021/bi0498252
PubMed ID: 15451669
Title: Apo and inhibitor complex structures of BACE (beta-secretase).
PubMed ID: 15451669
PubMed ID: 15628850
Title: Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).
PubMed ID: 15628850
DOI: 10.1021/bi048106k
Sequence Information:
- Length: 501
- Mass: 55764
- Checksum: 377CE4C824ACEF05
- Sequence:
MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE PEEPGRRGSF VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARP DDSLEPFFDS LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW RCLRCLRQQH DDFADDISLL K
Genular Protein ID: 3923253819
Symbol: B7Z3Z4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 401
- Mass: 45017
- Checksum: A8D5B1113A78C521
- Sequence:
MVPFIYLQAH FTLCSGWSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARP DDSLEPFFDS LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW RCLRCLRQQH DDFADDISLL K
Genular Protein ID: 2271752987
Symbol: Q5W9H2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15491607
Title: Alternative splice variants encoding unstable protein domains exist in the human brain.
PubMed ID: 15491607
Sequence Information:
- Length: 396
- Mass: 44429
- Checksum: A2CBCD52DCC089E0
- Sequence:
YLQAHFTLCS GWSSTYRDLR KGVYVPYTQG KWEGELGTDL VSIPHGPNVT VRANIAAITE SDKFFINGSN WEGILGLAYA EIARPDDSLE PFFDSLVKQT HVPNLFSLQL CGAGFPLNQS EVLASVGGSM IIGGIDHSLY TGSLWYTPIR REWYYEVIIV RVEINGQDLK MDCKEYNYDK SIVDSGTTNL RLPKKVFEAA VKSIKAASST EKFPDGFWLG EQLVCWQAGT TPWNIFPVIS LYLMGEVTNQ SFRITILPQQ YLRPVEDVAT SQDDCYKFAI SQSSTGTVMG AVIMEGFYVV FDRARKRIGF AVSACHVHDE FRTAAVEGPF VTLDMEDCGY NIPQTDESTL MTIAYVMAAI CALFMLPLCL MVCQWRCLRC LRQQHDDFAD DISLLK
Genular Protein ID: 2095108837
Symbol: B7Z3K2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 376
- Mass: 42160
- Checksum: 93E4D8C553E23716
- Sequence:
MVPFIYLQAH FTLCSGWSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARL CGAGFPLNQS EVLASVGGSM IIGGIDHSLY TGSLWYTPIR REWYYEVIIV RVEINGQDLK MDCKEYNYDK SIVDSGTTNL RLPKKVFEAA VKSIKAASST EKFPDGFWLG EQLVCWQAGT TPWNIFPVIS LYLMGEVTNQ SFRITILPQQ YLRPVEDVAT SQDDCYKFAI SQSSTGTVMG AVIMEGFYVV FDRARKRIGF AVSACHVHDE FRTAAVEGPF VTLDMEDCGY NIPQTDESTL MTIAYVMAAI CALFMLPLCL MVCQWRCLRC LRQQHDDFAD DISLLK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.