Details for: CBLC

Gene ID: 23624

Symbol: CBLC

Ensembl ID: ENSG00000142273

Description: Cbl proto-oncogene C

Associated with

Other Information

Genular Protein ID: 2173805495

Symbol: CBLC_HUMAN

Name: E3 ubiquitin-protein ligase CBL-C

UniProtKB Accession Codes:

Q9ULV8 Q8N1E5 Q9Y5Z2 Q9Y5Z3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10571044

Title: Molecular cloning and characterization of a novel cbl-family gene, cbl-c.

PubMed ID: 10571044

DOI: 10.1016/s0378-1119(99)00356-x

PubMed ID: 10362357

Title: cbl-3: a new mammalian cbl family protein.

PubMed ID: 10362357

DOI: 10.1038/sj.onc.1202753

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14661060

Title: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

PubMed ID: 14661060

DOI: 10.1038/sj.onc.1207298

PubMed ID: 18753381

Title: CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.

PubMed ID: 18753381

DOI: 10.1523/jneurosci.2738-08.2008

PubMed ID: 20525694

Title: The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

PubMed ID: 20525694

DOI: 10.1074/jbc.m109.091157

PubMed ID: 23145173

Title: Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.

PubMed ID: 23145173

DOI: 10.1371/journal.pone.0049428

PubMed ID: 22888118

Title: Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.

PubMed ID: 22888118

DOI: 10.1093/jb/mvs085

Sequence Information:

  • Length: 474
  • Mass: 52456
  • Checksum: 202634AEDE434544
  • Sequence:
    • MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH 
SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ 
LAKLAIIFSH MHAELHALFP GGKYCGHMYQ LTKAPAHTFW RESCGARCVL PWAEFESLLG 
TCHPVEPGCT ALALRTTIDL TCSGHVSIFE FDVFTRLFQP WPTLLKNWQL LAVNHPGYMA 
FLTYDEVQER LQACRDKPGS YIFRPSCTRL GQWAIGYVSS DGSILQTIPA NKPLSQVLLE 
GQKDGFYLYP DGKTHNPDLT ELGQAEPQQR IHVSEEQLQL YWAMDSTFEL CKICAESNKD 
VKIEPCGHLL CSCCLAAWQH SDSQTCPFCR CEIKGWEAVS IYQFHGQATA EDSGNSSDQE 
GRELELGQVP LSAPPLPPRP DLPPRKPRNA QPKVRLLKGN SPPAALGPQD PAPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.