Details for: PRND

Gene ID: 23627

Symbol: PRND

Ensembl ID: ENSG00000171864

Description: prion like protein doppel

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.99
    Marker Score: 2,625
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.22
    Marker Score: 930
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.92
    Marker Score: 2,792
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.68
    Marker Score: 1,578
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.3
    Marker Score: 7,699
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,820
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,062
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1
    Marker Score: 2,064
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2,478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.89
    Marker Score: 681
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 477
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,507
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.68
    Marker Score: 721
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 503
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8,277
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 145
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 431
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.41
    Marker Score: 412
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.39
    Marker Score: 732
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.34
    Marker Score: 575
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 160
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 617
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.26
    Marker Score: 200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.24
    Marker Score: 224
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 123
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 102
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.23
    Marker Score: 297
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.22
    Marker Score: 122
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.22
    Marker Score: 51
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.21
    Marker Score: 360
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 181
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.17
    Marker Score: 154
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 127
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.06
    Marker Score: 82
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.05
    Marker Score: 101
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.04
    Marker Score: 2,204
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 107
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 59
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.03
    Marker Score: 1,689
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.03
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRND is a single-copy gene located on chromosome 1q21, with an Ensembl ID of ENSG00000171864. It is significantly expressed in hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, endothelial cells, enteroendocrine cells, and other cell types. The protein sequence of PRND exhibits high homology to the prion protein, but lacks the characteristic beta-sheet structure associated with prion diseases. Instead, PRND contains a GPI-anchored protein motif, suggesting a role in cell-cell interactions and signaling. **Pathways and Functions:** PRND is implicated in several cellular pathways, including: 1. **Acrosome reaction**: PRND is expressed in sperm cells, where it may play a role in the acrosome reaction, a critical step in fertilization. 2. **Copper ion binding**: PRND contains a copper-binding motif, suggesting a potential role in copper homeostasis and redox regulation. 3. **External side of plasma membrane**: PRND is GPI-anchored, allowing it to interact with the external surface of cells, where it may participate in cell-cell adhesion and signaling. 4. **Intracellular copper ion homeostasis**: PRND may contribute to the regulation of copper ions within cells, influencing redox reactions and cellular metabolism. 5. **Protein binding and homooligomerization**: PRND interacts with other proteins, including itself, forming homooligomers that may regulate protein function and stability. **Clinical Significance:** While PRND does not exhibit the same level of pathogenicity as the prion protein, its expression in various cell types and involvement in cellular processes suggest potential implications for human health. Some possible areas of clinical significance include: 1. **Reproductive health**: PRND's role in the acrosome reaction and sperm cell function may be relevant to male infertility or reproductive disorders. 2. **Neurological disorders**: The expression of PRND in cerebral cortex GABAergic interneurons and forebrain radial glial cells may suggest a potential role in neurodevelopmental or neurodegenerative diseases. 3. **Cancer**: PRND's involvement in cell-cell interactions and signaling may contribute to tumorigenesis or cancer progression. In conclusion, the Prion-like Protein Doppel (PRND) is a protein with a complex role in various cellular processes, from cell-cell interactions and signaling to copper homeostasis and redox regulation. While its clinical significance is still being explored, further research into PRND's functions and pathways may uncover new insights into human health and disease.

Genular Protein ID: 667384810

Symbol: PRND_HUMAN

Name: Prion-like protein doppel

UniProtKB Accession Codes:

Q9UKY0 A7U7M5 Q9H311 Q9H312 Q9NTM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10525406

Title: Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

PubMed ID: 10525406

DOI: 10.1006/jmbi.1999.3108

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11063595

Title: Expression and structural characterization of the recombinant human doppel protein.

PubMed ID: 11063595

DOI: 10.1021/bi001523m

PubMed ID: 12200435

Title: The human 'prion-like' protein Doppel is expressed in both Sertoli cells and spermatozoa.

PubMed ID: 12200435

DOI: 10.1074/jbc.m206357200

PubMed ID: 15218028

Title: Copper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein.

PubMed ID: 15218028

DOI: 10.1074/jbc.m404341200

PubMed ID: 20411530

Title: A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein.

PubMed ID: 20411530

DOI: 10.1002/chem.200902405

PubMed ID: 12595265

Title: NMR structure of the human doppel protein.

PubMed ID: 12595265

DOI: 10.1016/s0022-2836(02)01471-7

PubMed ID: 10825657

Title: First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases.

PubMed ID: 10825657

DOI: 10.1016/s0304-3940(00)01100-9

PubMed ID: 11702213

Title: Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.

PubMed ID: 11702213

DOI: 10.1007/s004390100591

Sequence Information:

  • Length: 176
  • Mass: 20293
  • Checksum: A0F41EB0DFEED236
  • Sequence:
    • MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ VAENRPGAFI 
KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT KEAFVTGCIN ATQAANQGEF 
QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE RGAGLRVTMH QPVLLCLLAL IWLTVK

Genular Protein ID: 875692980

Symbol: A7U7M2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7U7M2

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 DNASU 1 EMBL 7 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 3 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 176
  • Mass: 20324
  • Checksum: A0F40980DFEED236
  • Sequence:
    • MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ VAENRPGAFI 
KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT KEAFVTGCIN ATQAANQGEF 
QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE RGAGLRVTMH QPVLLCLLAL IWLMVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.