PRND | ENSG00000171864 | NCBI 23627

Details for: PRND

Gene ID: 23627

Symbol: PRND

Ensembl ID: ENSG00000171864

Description: prion like protein doppel

Associated with

Metabolism of proteins
(R-HSA-392499)
Post-translational modification: synthesis of gpi-anchored proteins
(R-HSA-163125)
Post-translational protein modification
(R-HSA-597592)
Acrosome reaction
(GO:0007340)
Copper ion binding
(GO:0005507)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Intracellular copper ion homeostasis
(GO:0006878)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)

Other Information

Proteins

Prion-like protein doppel
A7U7M2_HUMAN

Genular Protein ID: 667384810

Symbol: PRND_HUMAN

Name: Prion-like protein doppel

UniProtKB Accession Codes:

Q9UKY0 A7U7M5 Q9H311 Q9H312 Q9NTM4

Database IDs:

Citations:

PubMed ID: 10525406

Title: Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

PubMed ID: 10525406

DOI: 10.1006/jmbi.1999.3108

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11063595

Title: Expression and structural characterization of the recombinant human doppel protein.

PubMed ID: 11063595

DOI: 10.1021/bi001523m

PubMed ID: 12200435

Title: The human 'prion-like' protein Doppel is expressed in both Sertoli cells and spermatozoa.

PubMed ID: 12200435

DOI: 10.1074/jbc.m206357200

PubMed ID: 15218028

Title: Copper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein.

PubMed ID: 15218028

DOI: 10.1074/jbc.m404341200

PubMed ID: 20411530

Title: A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein.

PubMed ID: 20411530

DOI: 10.1002/chem.200902405

PubMed ID: 12595265

Title: NMR structure of the human doppel protein.

PubMed ID: 12595265

DOI: 10.1016/s0022-2836(02)01471-7

PubMed ID: 10825657

Title: First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases.

PubMed ID: 10825657

DOI: 10.1016/s0304-3940(00)01100-9

PubMed ID: 11702213

Title: Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.

PubMed ID: 11702213

DOI: 10.1007/s004390100591

Sequence Information:

Length: 176
Mass: 20293
Checksum: A0F41EB0DFEED236
Sequence:

MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ VAENRPGAFI 
KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT KEAFVTGCIN ATQAANQGEF 
QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE RGAGLRVTMH QPVLLCLLAL IWLTVK

Genular Protein ID: 875692980

Symbol: A7U7M2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7U7M2

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 176
Mass: 20324
Checksum: A0F40980DFEED236
Sequence:

MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ VAENRPGAFI 
KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT KEAFVTGCIN ATQAANQGEF 
QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE RGAGLRVTMH QPVLLCLLAL IWLMVK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRND

Associated with

Other Information

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. PubMed ID: 10525406

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression and structural characterization of the recombinant human doppel protein. PubMed ID: 11063595

The human 'prion-like' protein Doppel is expressed in both Sertoli cells and spermatozoa. PubMed ID: 12200435

Copper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein. PubMed ID: 15218028

A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein. PubMed ID: 20411530

NMR structure of the human doppel protein. PubMed ID: 12595265

First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases. PubMed ID: 10825657

Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. PubMed ID: 11702213

The sequence of the human genome. PubMed ID: 11181995