Details for: KCNE5

Gene ID: 23630

Symbol: KCNE5

Ensembl ID: ENSG00000176076

Description: potassium voltage-gated channel subfamily E regulatory subunit 5

Associated with

  • Cardiac conduction
    (R-HSA-5576891)
  • Muscle contraction
    (R-HSA-397014)
  • Phase 2 - plateau phase
    (R-HSA-5576893)
  • Phase 3 - rapid repolarisation
    (R-HSA-5576890)
  • Atrial cardiac muscle cell action potential
    (GO:0086014)
  • Cardiac muscle contraction
    (GO:0060048)
  • Delayed rectifier potassium channel activity
    (GO:0005251)
  • Membrane repolarization during action potential
    (GO:0086011)
  • Membrane repolarization during ventricular cardiac muscle cell action potential
    (GO:0098915)
  • Negative regulation of delayed rectifier potassium channel activity
    (GO:1902260)
  • Negative regulation of potassium ion export across plasma membrane
    (GO:1903765)
  • Negative regulation of potassium ion transmembrane transport
    (GO:1901380)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of potassium ion transmembrane transport
    (GO:1901381)
  • Potassium channel regulator activity
    (GO:0015459)
  • Potassium ion export across plasma membrane
    (GO:0097623)
  • Protein binding
    (GO:0005515)
  • Regulation of atrial cardiac muscle cell membrane repolarization
    (GO:0060372)
  • Regulation of cation channel activity
    (GO:2001257)
  • Regulation of heart contraction
    (GO:0008016)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of membrane repolarization
    (GO:0060306)
  • Regulation of potassium ion transmembrane transport
    (GO:1901379)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Transmembrane transporter binding
    (GO:0044325)
  • Ventricular cardiac muscle cell action potential
    (GO:0086005)
  • Voltage-gated potassium channel activity
    (GO:0005249)
  • Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
    (GO:0086008)
  • Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
    (GO:1902282)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Other Information

Genular Protein ID: 3176296666

Symbol: KCNE5_HUMAN

Name: Potassium voltage-gated channel subfamily E regulatory beta subunit 5

UniProtKB Accession Codes:

Q9UJ90 Q5JWV7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 GO 21 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10493825

Title: KCNE1-like gene is deleted in AMME contiguous gene syndrome: Identification and characterization of the human and mouse homologs.

PubMed ID: 10493825

DOI: 10.1006/geno.1999.5904

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12324418

Title: KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.

PubMed ID: 12324418

DOI: 10.1016/s0006-3495(02)73961-1

PubMed ID: 20533308

Title: Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting.

PubMed ID: 20533308

DOI: 10.1002/jcp.22265

PubMed ID: 12011158

Title: Alport syndrome and mental retardation: clinical and genetic dissection of the contiguous gene deletion syndrome in Xq22.3 (ATS-MR).

PubMed ID: 12011158

DOI: 10.1136/jmg.39.5.359

PubMed ID: 16054468

Title: Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation.

PubMed ID: 16054468

DOI: 10.1016/j.amjcard.2005.03.086

PubMed ID: 18313602

Title: Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation.

PubMed ID: 18313602

DOI: 10.1016/j.hrthm.2007.12.019

PubMed ID: 21493962

Title: KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.

PubMed ID: 21493962

DOI: 10.1161/circep.110.959619

Sequence Information:

  • Length: 142
  • Mass: 14993
  • Checksum: ED8EC611CDE66BFE
  • Sequence:
    • MNCSESQRLR TLLSRLLLEL HHRGNASGLG AGPRPSMGMG VVPDPFVGRE VTSAKGDDAY 
LYILLIMIFY ACLAGGLILA YTRSRKLVEA KDEPSQACAE HEWAPGGALT ADAEAAAGSQ 
AEGRRQLASE GLPALAQGAE RV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.