Details for: HSPBP1

Gene ID: 23640

Symbol: HSPBP1

Ensembl ID: ENSG00000133265

Description: HSPA (Hsp70) binding protein 1

Associated with

Other Information

Genular Protein ID: 3433469592

Symbol: HPBP1_HUMAN

Name: Heat shock protein-binding protein 1

UniProtKB Accession Codes:

Q9NZL4 B3KQP0 B4DG11 O95351 Q6ZNU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9830037

Title: Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein.

PubMed ID: 9830037

DOI: 10.1074/jbc.273.49.32883

PubMed ID: 10786638

Title: Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70.

PubMed ID: 10786638

DOI: 10.1016/s0167-4781(99)00238-9

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12651857

Title: HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain.

PubMed ID: 12651857

DOI: 10.1074/jbc.m301109200

PubMed ID: 15215316

Title: The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.

PubMed ID: 15215316

DOI: 10.1091/mbc.e04-04-0293

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21247889

Title: The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.

PubMed ID: 21247889

DOI: 10.1074/jbc.m110.163436

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15694338

Title: Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.

PubMed ID: 15694338

DOI: 10.1016/j.molcel.2004.12.023

Sequence Information:

  • Length: 359
  • Mass: 39303
  • Checksum: 99C3B7ECD4DFAF33
  • Sequence:
    • MSDEGSRGSR LPLALPPASQ GCSSGGGGGG SSAGGSGNSR PPRNLQGLLQ MAITAGSEEP 
DPPPEPMSEE RRQWLQEAMS AAFRGQREEV EQMKSCLRVL SQPMPPTAGE AEQAADQQER 
EGALELLADL CENMDNAADF CQLSGMHLLV GRYLEAGAAG LRWRAAQLIG TCSQNVAAIQ 
EQVLGLGALR KLLRLLDRDA CDTVRVKALF AISCLVREQE AGLLQFLRLD GFSVLMRAMQ 
QQVQKLKVKS AFLLQNLLVG HPEHKGTLCS MGMVQQLVAL VRTEHSPFHE HVLGALCSLV 
TDFPQGVREC REPELGLEEL LRHRCQLLQQ HEEYQEELEF CEKLLQTCFS SPADDSMDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.